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Index > Protein center > Slc12a5(Gene name) > Mouse
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  • Slc12a5 (Gene name),
  • Solute carrier family 12 member 5 (Protein name ),  S12A5_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Slc12a5(Kcc2;Kiaa1176);
    Protein name:
    Solute carrier family 12 member 5;
    Alternative:
    K-Cl cotransporter 2(mKCC2);Electroneutral potassium-chloride cotransporter 2;Neuronal K-Cl cotransporter;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Homomultimer and heteromultimer with other K-Cl cotransporters (By similarity). Interacts with AP2A1.
    Function:
    Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons.
    Subcellular Location:
    Cell projection dendrite Cell membrane Multi-pass membrane protein Detected on dendrites, but not on axons of spinal cord neurons and at GPHN-positive inhibitory synapses.
    Protein Attributes:
    Sequence length:
    1138
    Sequence:
    50:
    MSRRFTVTSL | PPAASAASAD | PESRRHSVAD | PRRLPREDVK | GDGNPKESSP | 
    100:
    FINSTDTEKG | REYDGRNMAL | FEEEMDTSPM | VSSLLSGLAN | YTNLPQGSRE | 
    150:
    HEEAENNEGG | KKKPVQAPRM | GTFMGVYLPC | LQNIFGVILF | LRLTWVVGIA | 
    200:
    GIMESFCMVF | ICCSCTMLTA | ISMSAIATNG | VVPAGGSYYM | ISRSLGPEFG | 
    250:
    GAVGLCFYLG | TTFAGAMYIL | GTIEILLAYL | FPAMAIFKAE | DASGEAAAML | 
    300:
    NNMRVYGTCV | LTCMATVVFV | GVKYVNKFAL | VFLGCVILSI | LAIYAGVIKS | 
    350:
    AFDPPNFPIC | LLGNRTLSRH | GFDVCAKLAW | EGNETVTTRL | WGLFCSSRLL | 
    400:
    NATCDEYFTR | NNVTEIQGIP | GAASGLIKEN | LWSSYLTKGV | IVERRGMPSV | 
    450:
    GLADGTPVDM | DHPYVFSDMT | SYFTLLVGIY | FPSVTGIMAG | SNRSGDLRDA | 
    500:
    QKSIPTGTIL | AIATTSAVYI | SSVVLFGACI | EGVVLRDKFG | EAVNGNLVVG | 
    550:
    TLAWPSPWVI | VIGSFFSTCG | AGLQSLTGAP | RLLQAISRDG | IVPFLQVFGH | 
    600:
    GKANGEPTWA | LLLTACICEI | GILIASLDEV | APILSMFFLM | CYMFVNLACA | 
    650:
    VQTLLRTPNW | RPRFRYYHWT | LSFLGMSLCL | ALMFICSWYY | ALVAMLIAGL | 
    700:
    IYKYIEYRGA | EKEWGDGIRG | LSLSAARYAL | LRLEEGPPHT | KNWRPQLLVL | 
    750:
    VRVDQDQNVV | HPQLLSLTSQ | LKAGKGLTIV | GSVLEGTFLD | NHPQAQRAEE | 
    800:
    SIRRLMEAEK | VKGFCQVVIS | SNLRDGVSHL | IQSGGLGGLQ | HNTVLVGWPR | 
    850:
    NWRQKEDHQT | WRNFIELVRE | TTAGHLALLV | TKNVSMFPGN | PERFSEGSID | 
    900:
    VWWIVHDGGM | LMLLPFLLRH | HKVWRKCKMR | IFTVAQMDDN | SIQMKKDLTT | 
    950:
    FLYHLRITAE | VEVVEMHESD | ISAYTYEKTL | VMEQRSQILK | QMHLTKNERE | 
    1000:
    REIQSITDES | RGSIRRKNPA | NPRLRLNVPE | ETACDNEEKP | EEEVQLIHDQ | 
    1050:
    SAPSCPSSSP | SPGEEPEGER | ETDPEVHLTW | TKDKSVAEKN | KGPSPVSSEG | 
    1100:
    IKDFFSMKPE | WENLNQSNVR | RMHTAVRLNE | VIVNKSRDAK | LVLLNMPGPP | 
    1138:
    RNRNGDENYM | EFLEVLTEQL | DRVMLVRGGG | REVITIYS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    KEGG:
    String:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Solute carrier family 12 member 5
    Cat.:
    E9328m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Solute carrier family 12 member 5
    Cat.:
    E9328h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Mouse Solute carrier family 12 member 5
    Cat.:
    E9328r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Solute carrier family 12 member 5
    Cat.:
    U9328m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Solute carrier family 12 member 5
    Cat.:
    U9328h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Mouse Solute carrier family 12 member 5
    Cat.:
    U9328r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Mouse Solute carrier family 12 member 5
    Cat.:
    P9328Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Solute carrier family 12 member 5
    Cat.:
    P9328Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Solute carrier family 12 member 5
    Cat.:
    P9328Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Solute carrier family 12 member 5
    Monoclonal Antibody for Mouse Solute carrier family 12 member 5
    Monoclonal Antibody for Mouse Solute carrier family 12 member 5
    Protein for Mouse Solute carrier family 12 member 5
    Protein for Mouse Solute carrier family 12 member 5
    Protein for Mouse Solute carrier family 12 member 5

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "High-throughput sequence identification of gene coding variants within alcohol-related QTLs."
      Ehringer M.A. , Thompson J. , Conroy O. , Xu Y. , Yang F. , Canniff J. , Beeson M. , Gordon L. , Bennett B. , Johnson T.E. , Sikela J.M.
      Mamm. Genome12:657-663(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      strain: ILS.
      strain: ISS.
    2. 2.
      "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N. , Kikuno R. , Ohara R. , Inamoto S. , Aizawa H. , Yuasa S. , Nakajima D. , Nagase T. , Ohara O. , Koga H.
      DNA Res.10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Brain.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      strain: C57BL/6.
      tissue: Brain.
    6. 6.
      "An efficient DNA sequencing strategy based on bacteriophage Mu in vitro DNA transposition reaction."
      Haapa S. , Suomalainen S. , Eerikaeinen S. , Airaksinen M. , Paulin L. , Savilahti H.
      Genome Res.9:308-315(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-227 (ISOFORM 2)
    7. 7.
      "A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2."
      Uvarov P. , Ludwig A. , Markkanen M. , Pruunsild P. , Kaila K. , Delpire E. , Timmusk T. , Rivera C. , Airaksinen M.S.
      J. Biol. Chem.282:30570-30576(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72 (ISOFORM 1);TISSUE SPECIFICITY;DISRUPTION PHENOTYPE
    8. 8.
      Lubec G. , Kang S.U.
      Submitted (2007-04) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 532-538; 726-747; 813-819; 833-843; 952-961; 1042-1052; 1078-1085 AND 1091-1101;IDENTIFICATION BY MASS SPECTROMETRY
      strain: C57BL/6.
      tissue: Brain.
    9. 9.
      "Disruption of KCC2 reveals an essential role of K-Cl cotransport already in early synaptic inhibition."
      Huebner C.A. , Stein V. , Hermans-Borgmeyer I. , Meyer T. , Ballanyi K. , Jentsch T.J.
      Neuron30:515-524(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 10.
      "Identification of a novel di-leucine motif mediating K(+)/Cl(-) cotransporter KCC2 constitutive endocytosis."
      Zhao B. , Wong A.Y.C. , Murshid A. , Bowie D. , Presley J.F. , Bedford F.K.
      Cell. Signal.20:1769-1779(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AP2A1;MUTAGENESIS OF 680-LEU-LEU-681 AND 684-GLU-GLU-685
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