Slc12a5 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comSlc12a5 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Slc12a5(Gene name) > Rat

Slc12a5 (Gene name),

Solute carrier family 12 member 5 (Protein name ), S12A5_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Slc12a5(Kcc2);

Protein name:

Solute carrier family 12 member 5;

Alternative:

Furosemide-sensitive K-Cl cotransporter;Electroneutral potassium-chloride cotransporter 2;Neuronal K-Cl cotransporter;K-Cl cotransporter 2(rKCC2);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homomultimer and heteromultimer with other K-Cl cotransporters. Interacts with AP2A1.

Function:

Mediates electroneutral potassium-chloride cotransport in mature neurons. Transport occurs under isotonic conditions, but is activated 20-fold by cell swelling. Important for Cl(-) homeostasis in neurons. Necessary for the ontogenic change in response to gamma-aminobutyric acid (GABA) from depolarization to hyperpolarization during neuronal development.

Subcellular Location:

Membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

1139

Sequence:

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1139:

PRNRNGDENY | MEFLEVLTEQ | LDRVMLVRGG | GREVITIYS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00324

UniGene:

Rn.10513

KEGG:

rno:171373

String:

Q63633

Uniprot:

Q63633

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ELISA Kit for Rat Solute carrier family 12 member 5

Cat.:

E9328m

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MSDS:

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Packing:

96T

ELISA Kit for Rat Solute carrier family 12 member 5

Cat.:

E9328h

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MSDS:

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Packing:

96T

ELISA Kit for Rat Solute carrier family 12 member 5

Cat.:

E9328r

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Packing:

96T

CLIA Kit for Rat Solute carrier family 12 member 5

Cat.:

U9328m

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MSDS:

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Packing:

96T

CLIA Kit for Rat Solute carrier family 12 member 5

Cat.:

U9328h

Price:

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MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat Solute carrier family 12 member 5

Cat.:

U9328r

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat Solute carrier family 12 member 5

Cat.:

P9328Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Solute carrier family 12 member 5

Cat.:

P9328Rb-m

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat Solute carrier family 12 member 5

Cat.:

P9328Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rat Solute carrier family 12 member 5

Protein for Rat Solute carrier family 12 member 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular characterization of a putative K-Cl cotransporter in rat brain. A neuronal-specific isoform."
Payne J.A. , Stevenson T.J. , Donaldson L.F.
J. Biol. Chem.271:16245-16252(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain: Sprague-Dawley.
tissue: Brain.
2.

"A novel N-terminal isoform of the neuron-specific K-Cl cotransporter KCC2."
Uvarov P. , Ludwig A. , Markkanen M. , Pruunsild P. , Kaila K. , Delpire E. , Timmusk T. , Rivera C. , Airaksinen M.S.
J. Biol. Chem.282:30570-30576(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Wistar.
tissue: Hippocampus.
3.

"The K+/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation."
Rivera C. , Voipio J. , Payne J.A. , Ruusuvuori E. , Lahtinen H. , Lamsa K. , Pirvola U. , Saarma M. , Kaila K.
Nature397:251-255(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
4.

"A dominant negative mutant of the KCC1 K-Cl cotransporter: both N- and C-terminal cytoplasmic domains are required for K-Cl cotransport activity."
Casula S. , Shmukler B.E. , Wilhelm S. , Stuart-Tilley A.K. , Su W. , Chernova M.N. , Brugnara C. , Alper S.L.
J. Biol. Chem.276:41870-41878(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT

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