Protein name:
Sodium channel protein type 9 subunit alpha ;
Alternative:
Sodium channel protein type IX subunit alpha ;Peripheral sodium channel 1 (PN1) ;Voltage-gated sodium channel subunit alpha Nav1.7 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
The sodium channel consists of a large polypeptide and 2-3 smaller ones. This sequence represents a large polypeptide. Interacts with NEDD4 and NEDD4L.
Function:
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. It is a tetrodotoxin-sensitive Na(+) channel isoform. Plays a role in pain mechanisms, especially in the development of inflammatory pain.
Subcellular Location:
Membrane
Multi-pass membrane protein
In neurite terminals.
Protein Attributes:
50:
MAMLPPPGPQ | SFVHFTKQSL | ALIEQRISEE | KAKEHKDEKK | DDEEEGPKPS |
100:
SDLEAGKQLP | FIYGDIPPGM | VSEPLEDLDP | YYADKKTFIV | LNKGKAIFRF |
150:
NATPALYMLS | PFSPLRRISI | KILVHSLFSM | LIMCTILTNC | IFMTLSNPPE |
200:
WTKNVEYTFT | GIYTFESLIK | ILARGFCVGE | FTFLRDPWNW | LDFVVIVFAY |
250:
LTEFVNLGNV | SALRTFRVLR | ALKTISVIPG | LKTIVGALIQ | SVKKLSDVMI |
300:
LTVFCLSVFA | LIGLQLFMGN | LKHKCFRKEL | EENETLESIM | NTAESEEELK |
350:
KYFYYLEGSK | DALLCGFSTD | SGQCPEGYIC | VKAGRNPDYG | YTSFDTFSWA |
400:
FLALFRLMTQ | DYWENLYQQT | LRAAGKTYMI | FFVVVIFLGS | FYLINLILAV |
450:
VAMAYEEQNQ | ANIEEAKQKE | LEFQQMLDRL | KKEQEEAEAI | AAAAAEFTSI |
500:
GRSRIMGLSE | SSSETSRLSS | KSAKERRNRR | KKKKQKMSSG | EEKGDDEKLS |
550:
KSGSEESIRK | KSFHLGVEGH | HRTREKRLST | PNQSPLSIRG | SLFSARRSSR |
600:
TSLFSFKGRG | RDLGSETEFA | DDEHSIFGDN | ESRRGSLFVP | HRPRERRSSN |
650:
ISQASRSPPV | LPVNGKMHSA | VDCNGVVSLV | DGPSALMLPN | GQLLPEVIID |
700:
KATSDDSGTT | NQMRKKRLSS | SYFLSEDMLN | DPHLRQRAMS | RASILTNTVE |
750:
ELEESRQKCP | PWWYRFAHTF | LIWNCSPYWI | KFKKLIYFIV | MDPFVDLAIT |
800:
ICIVLNTLFM | AMEHHPMTEE | FKNVLAVGNL | IFTGIFAAEM | VLKLIAMDPY |
850:
EYFQVGWNIF | DSLIVTLSLI | ELFLADVEGL | SVLRSFRLLR | VFKLAKSWPT |
900:
LNMLIKIIGN | SVGALGNLTL | VLAIIVFIFA | VVGMQLFGKS | YKECVCKINV |
950:
DCKLPRWHMN | DFFHSFLIVF | RVLCGEWIET | MWDCMEVAGQ | TMCLIVYMMV |
1000:
MVIGNLVVLN | LFLALLLSSF | SSDNLTAIEE | DTDANNLQIA | VARIKRGINY |
1050:
VKQTLREFIL | KSFSKKPKGS | KDTKRTADPN | NKKENYISNR | TLAEMSKDHN |
1100:
FLKEKDRISG | YGSSLDKSFM | DENDYQSFIH | NPSLTVTVPI | APGESDLEIM |
1150:
NTEELSSDSD | SDYSKEKRNR | SSSSECSTVD | NPLPGEEEAE | AEPVNADEPE |
1200:
ACFTDGCVRR | FPCCQVNVDS | GKGKVWWTIR | KTCYRIVEHS | WFESFIVLMI |
1250:
LLSSGALAFE | DIYIEKKKTI | KIILEYADKI | FTYIFILEML | LKWVAYGYKT |
1300:
YFTNAWCWLD | FLIVDVSLVT | LVANTLGYSD | LGPIKSLRTL | RALRPLRALS |
1350:
RFEGMRVVVN | ALIGAIPSIM | NVLLVCLIFW | LIFSIMGVNL | FAGKFYECVN |
1400:
TTDGSRFPTS | QVANRSECFA | LMNVSGNVRW | KNLKVNFDNV | GLGYLSLLQV |
1450:
ATFKGWMDIM | YAAVDSVNVN | EQPKYEYSLY | MYIYFVIFII | FGSFFTLNLF |
1500:
IGVIIDNFNQ | QKKKLGGQDI | FMTEEQKKYY | NAMKKLGSKK | PQKPIPRPGN |
1550:
KFQGCIFDLV | TNQAFDITIM | VLICLNMVTM | MVEKEGQTEY | MDYVLHWINM |
1600:
VFIILFTGEC | VLKLISLRHY | YFTVGWNIFD | FVVVILSIVG | MFLAEMIEKY |
1650:
FVSPTLFRVI | RLARIGRILR | LIKGAKGIRT | LLFALMMSLP | ALFNIGLLLF |
1700:
LVMFIYAIFG | MSNFAYVKKE | AGINDMFNFE | TFGNSMICLF | QITTSAGWDG |
1750:
LLAPILNSAP | PDCDPKKVHP | GSSVEGDCGN | PSVGIFYFVS | YIIISFLVVV |
1800:
NMYIAVILEN | FSVATEESTE | PLSEDDFEMF | YEVWEKFDPD | ATQFIEFCKL |
1850:
SDFAAALDPP | LLIAKPNKVQ | LIAMDLPMVS | GDRIHCLDIL | FAFTKRVLGE |
1900:
GGEMDSLRSQ | MEERFMSANP | SKVSYEPITT | TLKRKQEEVS | ATIIQRAYRR |
1950:
YRLRQHVKNI | SSIYIKDGDR | DDDLPNKEDT | VFDNVNENSS | PEKTDVTAST |
1984:
ISPPSYDSVT | KPDQEKYETD | KTEKEDKEKD | ESRK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rabbit
Mouse
Rat
ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
ELISA Kit for Rat Sodium channel protein type 9 subunit alpha
CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
CLIA Kit for Rat Sodium channel protein type 9 subunit alpha
Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Polyclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Monoclonal Antibody for Rat Sodium channel protein type 9 subunit alpha
Protein for Rat Sodium channel protein type 9 subunit alpha
Protein for Rat Sodium channel protein type 9 subunit alpha
Protein for Rat Sodium channel protein type 9 subunit alpha
Protein for Rat Sodium channel protein type 9 subunit alpha
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons."
Toledo-Aral J.J.
,
Moss B.L.
,
He Z.J.
,
Koszowski A.G.
,
Whisenand T.
,
Levinson S.R.
,
Wolf J.J.
,
Silos-Santiago I.
,
Halegoua S.
,
Mandel G.
Proc. Natl. Acad. Sci. U.S.A.94:1527-1532(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;SUBCELLULAR LOCATION
2.
"A novel tetrodotoxin-sensitive, voltage-gated sodium channel expressed in rat and human dorsal root ganglia."
Sangameswaran L.
,
Fish L.M.
,
Koch B.D.
,
Rabert D.K.
,
Delgado S.G.
,
Ilnicka M.
,
Jakeman L.B.
,
Novakovic S.
,
Wong K.
,
Sze P.
,
Tzoumaka E.
,
Stewart G.R.
,
Herman R.C.
,
Chan H.
,
Eglen R.M.
,
Hunter J.C.
J. Biol. Chem.272:14805-14809(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue :
Spinal ganglion .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 527-547;IDENTIFICATION BY MASS SPECTROMETRY
strain :
Sprague-Dawley .
tissue :
Brain .