Sik1 ELISA Kit for Mouse(Mus musculus) | EIAab.comSik1 ELISA Kit for Mouse(Mus musculus)

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Sik1 (Gene name),

Serine/threonine-protein kinase SIK1 (Protein name ), SIK1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Sik1(Msk;Sik;Snf1lk);

Protein name:

Serine/threonine-protein kinase SIK1;

Alternative:

Myocardial SNF1-like kinase;HRT-20;Serine/threonine-protein kinase SNF1-like kinase 1(Serine/threonine-protein kinase SNF1LK);Salt-inducible protein kinase 1(SIK-1);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts (when phosphorylated on Thr-182 and Ser-186) with YWHAZ. Interacts with ATP1A1.

Function:

Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, gluconeogenesis and lipogenesis regulation, muscle growth and differentiation and tumor suppression. Phosphorylates HDAC4, HDAC5, PPME1, SREBF1, TORC1/CRTC1 and TORC2/CRTC2. Acts as a tumor suppressor and plays a key role in p53/TP53-dependent anoikis, a type of apoptosis triggered by cell detachment: required for phosphorylation of p53/TP53 in response to loss of adhesion and is able to suppress metastasis. Part of a sodium-sensing signaling network, probably by mediating phosphorylation of PPME1: following increases in intracellular sodium, SIK1 is activated by CaMK1 and phosphorylates PPME1 subunit of protein phosphatase 2A (PP2A), leading to dephosphorylation of sodium/potassium-transporting ATPase ATP1A1 and subsequent increase activity of ATP1A1. Acts as a regulator of muscle cells by phosphorylating and inhibiting class II histone deacetylases HDAC4 and HDAC5, leading to promote expression of MEF2 target genes in myocytes. Also required during cardiomyogenesis by regulating the exit of cardiomyoblasts from the cell cycle via down-regulation of CDKN1C/p57Kip2. Acts as a regulator of hepatic gluconeogenesis by phosphorylating and repressing the CREB-specific coactivators TORC1/CRTC1 and TORC2/CRTC2, leading to inhibit CREB activity. Also regulates hepatic lipogenesis by phosphorylating and inhibiting SREBF1.

Subcellular Location:

Cytoplasm Nucleus Following ACTH (adrenocorticotropic hormone) treatment and subsequent phosphorylation by PKA, translocates to the cytoplasm, where it binds to YWHAZ.

Protein Attributes:

Sequence length:

779

Sequence:

50:

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750:

779:

GCDPAGLPQG | DCEMEDLTSG | QRGTFVLVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q60670

UniGene:

Mm.290941

KEGG:

mmu:17691

Pfam:

PF00069

String:

Q60670

Uniprot:

Q60670

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ELISA Kit for Mouse Serine/threonine-protein kinase SIK1

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ELISA Kit for Mouse Serine/threonine-protein kinase SIK1

Cat.:

E14381h

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Manual:

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96T

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ELISA Kit for Mouse Serine/threonine-protein kinase SIK1

Cat.:

E14381m

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Packing:

96T

CLIA Kit for Mouse Serine/threonine-protein kinase SIK1

Cat.:

U14381h

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Manual:

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96T

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CLIA Kit for Mouse Serine/threonine-protein kinase SIK1

MSDS:

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CLIA Kit for Mouse Serine/threonine-protein kinase SIK1

Cat.:

U14381m

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Mouse Serine/threonine-protein kinase SIK1

Monoclonal Antibody for Mouse Serine/threonine-protein kinase SIK1

Protein for Mouse Serine/threonine-protein kinase SIK1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of novel protein kinases expressed in the myocardium of the developing mouse heart."
Ruiz J.C. , Conlon F.L. , Robertson E.J.
Mech. Dev.48:153-164(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Embryo.
2.

"The transcriptional landscape of the mammalian genome."
Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain: C57BL/6J.
tissue: Spinal ganglion.
3.

"ACTH-induced nucleocytoplasmic translocation of salt-inducible kinase. Implication in the protein kinase A-activated gene transcription in mouse adrenocortical tumor cells."
Takemori H. , Katoh Y. , Horike N. , Doi J. , Okamoto M.
J. Biol. Chem.277:42334-42343(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-577;MUTAGENESIS OF THR-268; THR-475 AND SER-577
4.

"Salt-inducible kinase-1 represses cAMP response element-binding protein activity both in the nucleus and in the cytoplasm."
Katoh Y. , Takemori H. , Min L. , Muraoka M. , Doi J. , Horike N. , Okamoto M.
Eur. J. Biochem.271:4307-4319(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;DOMAIN RK-RICH REGION;MUTAGENESIS OF 593-ARG-LYS-594; 597-ARG--LYS-599; 606-LYS--LYS-608; ILE-607 AND LEU-610
5.

"snf1lk encodes a protein kinase that may function in cell cycle regulation."
Stephenson A. , Huang G.Y. , Nguyen N.T. , Reuter S. , McBride J.L. , Ruiz J.C.
Genomics83:1105-1115(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-56
6.

"The CREB coactivator TORC2 is a key regulator of fasting glucose metabolism."
Koo S.-H. , Flechner L. , Qi L. , Zhang X. , Screaton R.A. , Jeffries S. , Hedrick S. , Xu W. , Boussouar F. , Brindle P. , Takemori H. , Montminy M.
Nature437:1109-1111(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF CRTC2;SUBCELLULAR LOCATION
7.

"Silencing the constitutive active transcription factor CREB by the LKB1-SIK signaling cascade."
Katoh Y. , Takemori H. , Lin X.-Z. , Tamura M. , Muraoka M. , Satoh T. , Tsuchiya Y. , Min L. , Doi J. , Miyauchi A. , Witters L.A. , Nakamura H. , Okamoto M.
FEBS J.273:2730-2748(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ENZYME REGULATION;SUBCELLULAR LOCATION;PHOSPHORYLATION AT THR-182 AND SER-577;MUTAGENESIS OF LYS-56; THR-182 AND SER-577
8.

"SIK1 is a class II HDAC kinase that promotes survival of skeletal myocytes."
Berdeaux R. , Goebel N. , Banaszynski L. , Takemori H. , Wandless T. , Shelton G.D. , Montminy M.
Nat. Med.13:597-603(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF HDAC4 AND HDAC5;INDUCTION;PHOSPHORYLATION AT SER-577;MUTAGENESIS OF LYS-56 AND SER-577
9.

"SIK1 couples LKB1 to p53-dependent anoikis and suppresses metastasis."
Cheng H. , Liu P. , Wang Z.C. , Zou L. , Santiago S. , Garbitt V. , Gjoerup O.V. , Iglehart J.D. , Miron A. , Richardson A.L. , Hahn W.C. , Zhao J.J.
Sci. Signal.2:RA35-RA35(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
10.

"Salt-inducible kinase regulates hepatic lipogenesis by controlling SREBP-1c phosphorylation."
Yoon Y.S. , Seo W.Y. , Lee M.W. , Kim S.T. , Koo S.H.
J. Biol. Chem.284:10446-10452(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN PHOSPHORYLATION OF SREBF1
11.

"Lack of sik1 in mouse embryonic stem cells impairs cardiomyogenesis by down-regulating the cyclin-dependent kinase inhibitor p57kip2."
Romito A. , Lonardo E. , Roma G. , Minchiotti G. , Ballabio A. , Cobellis G.
PLoS ONE5:E9029-E9029(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
12.

"The CRTC1-SIK1 pathway regulates entrainment of the circadian clock."
Jagannath A. , Butler R. , Godinho S.I. , Couch Y. , Brown L.A. , Vasudevan S.R. , Flanagan K.C. , Anthony D. , Churchill G.C. , Wood M.J. , Steiner G. , Ebeling M. , Hossbach M. , Wettstein J.G. , Duffield G.E. , Gatti S. , Hankins M.W. , Foster R.G. , more...
Cell154:1100-1111(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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