Protein name:
SPARC-related modular calcium-binding protein 1 ;
Alternative:
Secreted modular calcium-binding protein 1 (SMOC-1) ;SPARC-related gene protein ;
Organism:
Mouse (Mus musculus).
General Annotation
Function:
Plays essential roles in both eye and limb development. Probale regulator of osteoblast differentiation.
Subcellular Location:
Secreted
extracellular space
extracellular matrix
basement membrane
In or around the basement membrane.
Protein Attributes:
50:
MLPARVRLLT | PHLLLVLVQL | SPAGGHRTTG | PRFLISDRDP | PCNPHCPRTQ |
100:
PKPICASDGR | SYESMCEYQR | AKCRDPALAV | VHRGRCKDAG | QSKCRLERAQ |
150:
ALEQAKKPQE | AVFVPECGED | GSFTQVQCHT | YTGYCWCVTP | DGKPISGSSV |
200:
QNKTPVCSGP | VTDKPLSQGN | SGRKVSFRFF | LTLNSDDGSK | PTPTMETQPV |
250:
FDGDEITAPT | LWIKHLVIKD | SKLNNTNVRN | SEKVHSCDQE | RQSALEEARQ |
300:
NPREGIVIPE | CAPGGLYKPV | QCHQSTGYCW | CVLVDTGRPL | PGTSTRYVMP |
350:
SCESDARAKS | VEADDPFKDR | ELPGCPEGKK | MEFITSLLDA | LTTDMVQAIN |
400:
SAAPTGGGRF | SEPDPSHTLE | ERVAHWYFSQ | LDSNSSDDIN | KREMKPFKRY |
450:
VKKKAKPKKC | ARRFTDYCDL | NKDKVISLPE | LKGCLGVSKE | GGSLGSFPQG |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse SPARC-related modular calcium-binding protein 1
ELISA Kit for Mouse SPARC-related modular calcium-binding protein 1
CLIA Kit for Mouse SPARC-related modular calcium-binding protein 1
CLIA Kit for Mouse SPARC-related modular calcium-binding protein 1
Polyclonal Antibody for Mouse SPARC-related modular calcium-binding protein 1
Polyclonal Antibody for Mouse SPARC-related modular calcium-binding protein 1
Monoclonal Antibody for Mouse SPARC-related modular calcium-binding protein 1
Monoclonal Antibody for Mouse SPARC-related modular calcium-binding protein 1
Protein for Mouse SPARC-related modular calcium-binding protein 1
Protein for Mouse SPARC-related modular calcium-binding protein 1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"A Sparc-related gene (SRG)."
Poleev A.
,
Plachov D.
Submitted (1998-06) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
strain :
129/Sv .
2.
"The transcriptional landscape of the mammalian genome."
Carninci P.
,
Kasukawa T.
,
Katayama S.
,
Gough J.
,
Frith M.C.
,
Maeda N.
,
Oyama R.
,
Ravasi T.
,
Lenhard B.
,
Wells C.
,
Kodzius R.
,
Shimokawa K.
,
Bajic V.B.
,
Brenner S.E.
,
Batalov S.
,
Forrest A.R.
,
Zavolan M.
,
Davis M.J.
,
Wilming L.G.
,
Aidinis V.
,
Allen J.E.
,
Ambesi-Impiombato A.
,
Apweiler R.
,
Aturaliya R.N.
,
Bailey T.L.
,
Bansal M.
,
Baxter L.
,
Beisel K.W.
,
Bersano T.
,
Bono H.
,
Chalk A.M.
,
Chiu K.P.
,
Choudhary V.
,
Christoffels A.
,
Clutterbuck D.R.
,
Crowe M.L.
,
Dalla E.
,
Dalrymple B.P.
,
de Bono B.
,
Della Gatta G.
,
di Bernardo D.
,
Down T.
,
Engstrom P.
,
Fagiolini M.
,
Faulkner G.
,
Fletcher C.F.
,
Fukushima T.
,
Furuno M.
,
Futaki S.
,
Gariboldi M.
,
Georgii-Hemming P.
,
Gingeras T.R.
,
Gojobori T.
,
Green R.E.
,
Gustincich S.
,
Harbers M.
,
Hayashi Y.
,
Hensch T.K.
,
Hirokawa N.
,
Hill D.
,
Huminiecki L.
,
Iacono M.
,
Ikeo K.
,
Iwama A.
,
Ishikawa T.
,
Jakt M.
,
Kanapin A.
,
Katoh M.
,
Kawasawa Y.
,
Kelso J.
,
Kitamura H.
,
Kitano H.
,
Kollias G.
,
Krishnan S.P.
,
Kruger A.
,
Kummerfeld S.K.
,
Kurochkin I.V.
,
Lareau L.F.
,
Lazarevic D.
,
Lipovich L.
,
Liu J.
,
Liuni S.
,
McWilliam S.
,
Madan Babu M.
,
Madera M.
,
Marchionni L.
,
Matsuda H.
,
Matsuzawa S.
,
Miki H.
,
Mignone F.
,
Miyake S.
,
Morris K.
,
Mottagui-Tabar S.
,
Mulder N.
,
Nakano N.
,
Nakauchi H.
,
Ng P.
,
Nilsson R.
,
Nishiguchi S.
,
Nishikawa S.
,
Nori F.
,
Ohara O.
,
Okazaki Y.
,
Orlando V.
,
Pang K.C.
,
Pavan W.J.
,
Pavesi G.
,
Pesole G.
,
Petrovsky N.
,
Piazza S.
,
Reed J.
,
Reid J.F.
,
Ring B.Z.
,
Ringwald M.
,
Rost B.
,
Ruan Y.
,
Salzberg S.L.
,
Sandelin A.
,
Schneider C.
,
Schoenbach C.
,
Sekiguchi K.
,
Semple C.A.
,
Seno S.
,
Sessa L.
,
Sheng Y.
,
Shibata Y.
,
Shimada H.
,
Shimada K.
,
Silva D.
,
Sinclair B.
,
Sperling S.
,
Stupka E.
,
Sugiura K.
,
Sultana R.
,
Takenaka Y.
,
Taki K.
,
Tammoja K.
,
Tan S.L.
,
Tang S.
,
Taylor M.S.
,
Tegner J.
,
Teichmann S.A.
,
Ueda H.R.
,
van Nimwegen E.
,
Verardo R.
,
Wei C.L.
,
Yagi K.
,
Yamanishi H.
,
Zabarovsky E.
,
Zhu S.
,
Zimmer A.
,
Hide W.
,
Bult C.
,
Grimmond S.M.
,
Teasdale R.D.
,
Liu E.T.
,
Brusic V.
,
Quackenbush J.
,
Wahlestedt C.
,
Mattick J.S.
,
Hume D.A.
,
Kai C.
,
Sasaki D.
,
Tomaru Y.
,
Fukuda S.
,
Kanamori-Katayama M.
,
Suzuki M.
,
Aoki J.
,
Arakawa T.
,
Iida J.
,
Imamura K.
,
Itoh M.
,
Kato T.
,
Kawaji H.
,
Kawagashira N.
,
Kawashima T.
,
Kojima M.
,
Kondo S.
,
Konno H.
,
Nakano K.
,
Ninomiya N.
,
Nishio T.
,
Okada M.
,
Plessy C.
,
Shibata K.
,
Shiraki T.
,
Suzuki S.
,
Tagami M.
,
Waki K.
,
Watahiki A.
,
Okamura-Oho Y.
,
Suzuki H.
,
Kawai J.
,
Hayashizaki Y.
more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Aorta .
tissue :
Vein .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Mammary tumor .
4.
"SMOC1 is essential for ocular and limb development in humans and mice."
Okada I.
,
Hamanoue H.
,
Terada K.
,
Tohma T.
,
Megarbane A.
,
Chouery E.
,
Abou-Ghoch J.
,
Jalkh N.
,
Cogulu O.
,
Ozkinay F.
,
Horie K.
,
Takeda J.
,
Furuichi T.
,
Ikegawa S.
,
Nishiyama K.
,
Miyatake S.
,
Nishimura A.
,
Mizuguchi T.
,
Niikawa N.
,
Hirahara F.
,
Kaname T.
,
Yoshiura K.
,
Tsurusaki Y.
,
Doi H.
,
Miyake N.
,
Furukawa T.
,
Matsumoto N.
,
Saitsu H.
more...
Am. J. Hum. Genet.88:30-41(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE;DISRUPTION PHENOTYPE
5.
"Loss of the BMP antagonist, SMOC-1, causes Ophthalmo-acromelic (Waardenburg Anophthalmia) syndrome in humans and mice."
Rainger J.
,
van Beusekom E.
,
Ramsay J.K.
,
McKie L.
,
Al-Gazali L.
,
Pallotta R.
,
Saponari A.
,
Branney P.
,
Fisher M.
,
Morrison H.
,
Bicknell L.
,
Gautier P.
,
Perry P.
,
Sokhi K.
,
Sexton D.
,
Bardakjian T.M.
,
Schneider A.S.
,
Elcioglu N.
,
Ozkinay F.
,
Koenig R.
,
Megarbane A.
,
Semerci C.N.
,
Khan A.
,
Zafar S.
,
Hennekam R.
,
Sousa S.B.
,
Ramos L.
,
Garavelli L.
,
Furga A.S.
,
Wischmeijer A.
,
Jackson I.J.
,
Gillessen-Kaesbach G.
,
Brunner H.G.
,
Wieczorek D.
,
van Bokhoven H.
,
Fitzpatrick D.R.
more...
PLoS Genet.7:E1002114-E1002114(2011)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DEVELOPMENTAL STAGE