Gene name:
Unc13d (Unc13h4) ;
Protein name:
Protein unc-13 homolog D ;
Alternative:
Munc13-4 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with RAB27A and DOC2A.
Function:
Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
Subcellular Location:
Cytoplasm
Membrane
Peripheral membrane protein
Late endosome
Recycling endosome
Lysosome
Colocalizes with cytotoxic granules at the plasma membrane (By similarity). Localizes to endosomal exocytic vesicles.
Protein Attributes:
50:
MATHLSHPQR | RPPLLRQAVK | IRRRRVRDLQ | DPPPQATPEV | QVQSHHFSPE |
100:
ERDLLYEEAL | YTVLHRLGQP | EPNHVKEASE | LLCYLQEAFQ | VQPEEHQQML |
150:
QRVRELEKPI | FCLKATVKQA | KGILGKDVSG | FSDPYCLLGI | EQKVGVPEGS |
200:
PVSRRRQKAV | VRHTIPEEET | HRTQVKTQTL | NPVWDETFIL | EFEDITNASF |
250:
HLDMWDLDTV | ESVRHKLGEL | TDLHGLRRIF | KEARKDKGQD | DFLGNVMLRL |
300:
QDLRCREDQW | FPLEPCTETY | PDRGQCHLQF | QFIHKRRATV | ASRSQPSYTV |
350:
HFHLLQQLVS | HEVTQHQAGG | TSWGRIAESQ | AVTILFLHAT | QKDLSDFHQS |
400:
MAQWLAYSRL | YQSLEFPSSC | LLHPITSIEY | QWIQGRLKAE | QREELATSFT |
450:
SLLAYGLSLI | RKFRSVFPLS | VSDSPSRLQS | LLRVLVQMCK | MKAFGELCPD |
500:
SAPLPQLVSE | ALRMGTVEWF | HLMQQHHQPM | VQGILEAGKA | LLSLVQDVMG |
550:
DLYQCRRTWN | KIFHNVLKID | LFTMAFLELQ | WLVAKRVQDH | TAAVGDLVSP |
600:
DVGESLFQLY | VSLREFCQLG | PSDSHEVLAL | DGFHRWFQSA | IPSWLQRTYS |
650:
VALERVQRAV | QMDSLVPLGE | LTKHSTSAVD | LSTCFAQISH | TARQLDWPDP |
700:
EEAFMITVKF | VEDTCRLALV | YCSLIKARAR | ELSAVQKDQS | QAADMLCVVV |
750:
NNVERLRLII | DKLPTQLAWE | ALEQRVGAVL | EQGQLQNTLH | TQLQGALAGL |
800:
GHEIRTGVRT | LAEQLEVGIA | THIQKLIDAK | GSILPEDAIL | PLMKFLEVKL |
850:
CYMNTNLVQE | NFSSLLTLLW | THTLTVLVEA | AASHRNSSLA | SSRLKVALQN |
900:
LEICFHAEGC | GLPPEALHTD | TFLALQSDLE | LQAASSRELI | QKYFRSRIQQ |
950:
QAETTSERLG | AVTVKASYRA | SEQKLHVELL | SASSLLPLDS | NGSSDPFVQL |
1000:
TLEPRHEFPE | LAPRETQKHK | KELHPLFDET | FEFLVPAEPC | QKDGACLLLT |
1050:
VLDHDRLGAD | DLEGEAFLPL | CRVPGLTGCV | EPGEAPQMRL | PLTYPAPNGD |
1088:
PILRLLESRK | GDREAQAFVK | LRRQRAKQAS | QHAPATEP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Rat Protein unc-13 homolog D
ELISA Kit for Rat Protein unc-13 homolog D
ELISA Kit for Rat Protein unc-13 homolog D
CLIA Kit for Rat Protein unc-13 homolog D
CLIA Kit for Rat Protein unc-13 homolog D
CLIA Kit for Rat Protein unc-13 homolog D
Polyclonal Antibody for Rat Protein unc-13 homolog D
Polyclonal Antibody for Rat Protein unc-13 homolog D
Polyclonal Antibody for Rat Protein unc-13 homolog D
Monoclonal Antibody for Rat Protein unc-13 homolog D
Monoclonal Antibody for Rat Protein unc-13 homolog D
Monoclonal Antibody for Rat Protein unc-13 homolog D
Protein for Rat Protein unc-13 homolog D
Protein for Rat Protein unc-13 homolog D
Protein for Rat Protein unc-13 homolog D
R&D Technical Data
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Precision
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Recovery
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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References
1.
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Cited for : NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
strain :
Sprague-Dawley .
tissue :
Lung .