VPS29 ELISA Kit for Human(Homo sapiens) | EIAab.comVPS29 ELISA Kit for Human(Homo sapiens)

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VPS29 (Gene name),

Vacuolar protein sorting-associated protein 29 (Protein name ), VPS29_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

VPS29(DC7;DC15;MDS007);

Protein name:

Vacuolar protein sorting-associated protein 29(hVPS29);

Alternative:

Vesicle protein sorting 29;PEP11 homolog;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the retromer complex composed of VPS26 (VPS26A or VPS26B), VPS29, VPS35, SNX1 and SNX2. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN.

Function:

Essential component of the retromer complex, a complex required to retrieve lysosomal enzyme receptors (IGF2R and M6PR) from endosomes to the trans-Golgi network. Also required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA). Has low protein phosphatase activity towards a serine-phosphorylated peptide derived from IGF2R (in vitro).

Subcellular Location:

Cytoplasm Membrane Peripheral membrane protein Endosome membrane Peripheral membrane protein

Protein Attributes:

Sequence length:

182

Sequence:

50:

100:

150:

182:

VLMDIQASTV | VTYVYQLIGD | DVKVERIEYK | KP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:51699

String:

Q9UBQ0

SMR:

Q9UBQ0

Pfam:

PF12850

MIM:

606932

UniGene:

Hs.600114

STRING:

9606.ENSP00000380795

Uniprot:

Q9UBQ0

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ELISA Kit for Human hVPS29

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E5165h

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96T

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ELISA Kit for Human hVPS29

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E5165r

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96T

ELISA Kit for Human hVPS29

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E5165c

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96T

ELISA Kit for Human hVPS29

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E5165m

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96T

ELISA Kit for Human hVPS29

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E5165b

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96T

CLIA Kit for Human hVPS29

Cat.:

U5165c

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96T

CLIA Kit for Human hVPS29

Cat.:

U5165h

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96T

CLIA Kit for Human hVPS29

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U5165m

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96T

CLIA Kit for Human hVPS29

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U5165b

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96T

CLIA Kit for Human hVPS29

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U5165r

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Polyclonal Antibody for Human hVPS29

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P5165Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human hVPS29

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P5165Rb-h

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Polyclonal Antibody for Human hVPS29

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P5165Rb-r

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40ug/0.2ml

Monoclonal Antibody for Human hVPS29

Protein for Human hVPS29

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Human homologues of yeast vacuolar protein sorting 29 and 35."
Edgar A.J. , Polak J.M.
Biochem. Biophys. Res. Commun.277:622-630(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Lung.
2.

"Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes."
Renfrew Haft C. , de la Luz Sierra M. , Bafford R. , Lesniak M.A. , Barr V.A. , Taylor S.I.
Mol. Biol. Cell11:4105-4116(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INTERACTION WITH VPS26A; VPS35; SNX1 AND SNX2
tissue: Parathyroid.
3.

"Novel genes expressed in hematopoietic stem/progenitor cells from myelodysplastic syndrome patients."
Huang C. , Zhang C. , Tu Y. , Gu W. , Wang Y. , Han Z. , Chen Z. , Zhou J. , Gu J. , Huang Q. , Yu Y. , Xu S. , Ren S. , Fu G. , Li N.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Hematopoietic stem cell.
4.

"Novel genes expressed in human dendritic cells."
Peng Y. , Li Y. , Tu Y. , Xu S. , Han Z. , Fu G. , Chen Z.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Dendritic cell.
5.

"Towards a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs."
Wiemann S. , Weil B. , Wellenreuther R. , Gassenhuber J. , Glassl S. , Ansorge W. , Boecher M. , Bloecker H. , Bauersachs S. , Blum H. , Lauber J. , Duesterhoeft A. , Beyer A. , Koehrer K. , Strack N. , Mewes H.-W. , Ottenwaelder B. , Obermaier B. , more...
Genome Res.11:422-435(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Fetal brain.
6.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Brain.
tissue: Cervix.
8.

"The mammalian retromer regulates transcytosis of the polymeric immunoglobulin receptor."
Verges M. , Luton F. , Gruber C. , Tiemann F. , Reinders L.G. , Huang L. , Burlingame A.L. , Haft C.R. , Mostov K.E.
Nat. Cell Biol.6:763-769(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
9.

"The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide."
Damen E. , Krieger E. , Nielsen J.E. , Eygensteyn J. , van Leeuwen J.E.M.
Biochem. J.398:399-409(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF ASP-8; ASN-39; ASP-62; HIS-86 AND HIS-117;SUBUNIT
10.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-50;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
11.

"The cargo-selective retromer complex is a recruiting hub for protein complexes that regulate endosomal tubule dynamics."
Harbour M.E. , Breusegem S.Y. , Antrobus R. , Freeman C. , Reid E. , Seaman M.N.
J. Cell Sci.123:3703-3717(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TBC1D5;MUTAGENESIS OF LEU-152
12.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.

"A SNX3-dependent retromer pathway mediates retrograde transport of the Wnt sorting receptor Wntless and is required for Wnt secretion."
Harterink M. , Port F. , Lorenowicz M.J. , McGough I.J. , Silhankova M. , Betist M.C. , van Weering J.R. , van Heesbeen R.G. , Middelkoop T.C. , Basler K. , Cullen P.J. , Korswagen H.C.
Nat. Cell Biol.13:914-923(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE SNX3-RETROMER;SUBUNIT
14.

"VPS29 is not an active metallo-phosphatase but is a rigid scaffold required for retromer interaction with accessory proteins."
Swarbrick J.D. , Shaw D.J. , Chhabra S. , Ghai R. , Valkov E. , Norwood S.J. , Seaman M.N. , Collins B.M.
PLoS ONE6:E20420-E20420(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: LACK OF PHOSPHATASE ACTIVITY
15.

"Endosomal recruitment of the WASH complex: active sequences and mutations impairing interaction with the retromer."
Helfer E. , Harbour M.E. , Henriot V. , Lakisic G. , Sousa-Blin C. , Volceanov L. , Seaman M.N. , Gautreau A.
Biol. Cell105:191-207(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VPS35;MUTAGENESIS OF VAL-90 AND ILE-91
16.

"A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport."
Steinberg F. , Gallon M. , Winfield M. , Thomas E.C. , Bell A.J. , Heesom K.J. , Tavare J.M. , Cullen P.J.
Nat. Cell Biol.15:461-471(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX27 AND KIAA0196;SUBUNIT;FUNCTION OF THE SNX27-RETROMER
17.

"VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface."
Hesketh G.G. , Perez-Dorado I. , Jackson L.P. , Wartosch L. , Schafer I.B. , Gray S.R. , McCoy A.J. , Zeldin O.B. , Garman E.F. , Harbour M.E. , Evans P.R. , Seaman M.N. , Luzio J.P. , Owen D.J.
Dev. Cell29:591-606(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
18.

"Crystal structure of human vacuolar protein sorting protein 29 reveals a phosphodiesterase/nuclease-like fold and two protein-protein interaction sites."
Wang D. , Guo M. , Liang Z. , Fan J. , Zhu Z. , Zang J. , Zhu Z. , Li X. , Teng M. , Niu L. , Dong Y. , Liu P.
J. Biol. Chem.280:22962-22967(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS);METAL-BINDING
19.

"Functional architecture of the retromer cargo-recognition complex."
Hierro A. , Rojas A.L. , Rojas R. , Murthy N. , Effantin G. , Kajava A.V. , Steven A.C. , Bonifacino J.S. , Hurley J.H.
Nature449:1063-1067(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) IN COMPLEX WITH VPS35;ELECTRON MICROSCOPY OF THE RETROMER COMPLEX CONTAINING VPS29; VPS35 AND VPS26

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