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Index > Protein center > ELK1(Gene name) > Human
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  • ELK1 (Gene name),
  • ETS domain-containing protein Elk-1 (Protein name ),  ELK1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ELK1;
    Protein name:
    ETS domain-containing protein Elk-1;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts in its sumoylated form with PIAS2/PIASX which enhances its transcriptional activator activity. Interacts with MAD2L2; the interaction is direct and promotes phosphorylation by the kinases MAPK8 and/or MAPK9.
    Function:
    Stimulates transcription. Binds to purine-rich DNA sequences. Can form a ternary complex with the serum response factor and the ETS and SRF motifs of the fos serum response element.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    428
    Sequence:
    50:
    MDPSVTLWQF | LLQLLREQGN | GHIISWTSRD | GGEFKLVDAE | EVARLWGLRK | 
    100:
    NKTNMNYDKL | SRALRYYYDK | NIIRKVSGQK | FVYKFVSYPE | VAGCSTEDCP | 
    150:
    PQPEVSVTST | MPNVAPAAIH | AAPGDTVSGK | PGTPKGAGMA | GPGGLARSSR | 
    200:
    NEYMRSGLYS | TFTIQSLQPQ | PPPHPRPAVV | LPSAAPAGAA | APPSGSRSTS | 
    250:
    PSPLEACLEA | EEAGLPLQVI | LTPPEAPNLK | SEELNVEPGL | GRALPPEVKV | 
    300:
    EGPKEELEVA | GERGFVPETT | KAEPEVPPQE | GVPARLPAVV | MDTAGQAGGH | 
    350:
    AASSPEISQP | QKGRKPRDLE | LPLSPSLLGG | PGPERTPGSG | SGSGLQAPGP | 
    400:
    ALTPSLLPTH | TLTPVLLTPS | SLPPSIHFWS | TLSPIAPRSP | AKLSFQFPSS | 
    428:
    GSAQVHIPSI | SVDGLSTPVV | LSPGPQKP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    SMR:
    KEGG:
    Pfam:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human ETS domain-containing protein Elk-1
    ELISA Kit for Human ETS domain-containing protein Elk-1
    CLIA Kit for Human ETS domain-containing protein Elk-1
    CLIA Kit for Human ETS domain-containing protein Elk-1
    Polyclonal Antibody for Human ETS domain-containing protein Elk-1
    Polyclonal Antibody for Human ETS domain-containing protein Elk-1
    Monoclonal Antibody for Human ETS domain-containing protein Elk-1
    Monoclonal Antibody for Human ETS domain-containing protein Elk-1
    Protein for Human ETS domain-containing protein Elk-1
    Protein for Human ETS domain-containing protein Elk-1

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints."
      Rao V.N. , Huebner K. , Isobe M. , Ar-Rushdi A. , Croce C.M. , Reddy E.S.P.
      Science244:66-70(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ASN-183
    2. 2.
      "The human elk-1 gene family: the functional gene and two processed pseudogenes embedded in the IgH locus."
      Harindranath N. , Mills F.C. , Mitchell M.P. , Meindl A. , Max E.E.
      Gene221:215-224(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
    3. 3.
      "Novel family members HuER71, ELFR, and ELKv among ETS-related genes coexpressed with EWS-FLI1 in Ewing tumor cell lines."
      Aryee D.N.T. , Kovar H.
      Submitted (1997-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
    4. 4.
      "Structural organization of the human ELK1 gene and its processed pseudogene ELK2 genes."
      Yamauchi T. , Toko M. , Suga M. , Hatakeyama T. , Isobe M.
      DNA Res.6:21-27(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1)
      tissue: Hippocampus.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Urinary bladder.
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Uterus.
    9. 9.
      "ERK phosphorylation potentiates Elk-1-mediated ternary complex formation and transactivation."
      Gille H. , Kortenjann M. , Thomae O. , Moomaw C. , Slaughter C. , Cobb M.H. , Shaw P.E.
      EMBO J.14:951-962(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 318-331; 336-364 AND 380-408;PHOSPHORYLATION AT SER-324; THR-336; SER-383; SER-389 AND SER-422;MUTAGENESIS OF SER-324; THR-336; THR-353; THR-363; THR-368; SER-383; SER-389; THR-417 AND SER-422
    10. 10.
      "Elk-1 protein domains required for direct and SRF-assisted DNA-binding."
      Janknecht R. , Nordheim A.
      Nucleic Acids Res.20:3317-3324(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAINS
    11. 11.
      "Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade."
      Enslen H. , Tokumitsu H. , Stork P.J. , Davis R.J. , Soderling T.R.
      Proc. Natl. Acad. Sci. U.S.A.93:10803-10808(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY CAMK4
    12. 12.
      "Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinases MKK3 and MKK6."
      Enslen H. , Raingeaud J. , Davis R.J.
      J. Biol. Chem.273:1741-1748(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION BY MAPK11; MAPK12 AND MAPK14
    13. 13.
      "ERK activation induces phosphorylation of Elk-1 at multiple S/T-P motifs to high stoichiometry."
      Cruzalegui F.H. , Cano E. , Treisman R.
      Oncogene18:7948-7957(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT THR-353; THR-363; THR-368; SER-383; SER-389 AND THR-417
    14. 14.
      "Dynamic interplay of the SUMO and ERK pathways in regulating Elk-1 transcriptional activity."
      Yang S.-H. , Jaffray E. , Hay R.T. , Sharrocks A.D.
      Mol. Cell12:63-74(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-249;MUTAGENESIS OF LYS-230 AND LYS-249
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-230; LYS-249 AND LYS-254;MUTAGENESIS OF LYS-230; LYS-249 AND LYS-254
    16. 16.
      "SUMO promotes HDAC-mediated transcriptional repression."
      Yang S.-H. , Sharrocks A.D.
      Mol. Cell13:611-617(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION
    17. 17.
      "PIASx acts as an Elk-1 coactivator by facilitating derepression."
      Yang S.-H. , Sharrocks A.D.
      EMBO J.24:2161-2171(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PIAS2
    18. 18.
      "Rev7/MAD2B links c-Jun N-terminal protein kinase pathway signaling to activation of the transcription factor Elk-1."
      Zhang L. , Yang S.H. , Sharrocks A.D.
      Mol. Cell. Biol.27:2861-2869(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAD2L2;PHOSPHORYLATION AT SER-383;MUTAGENESIS OF SER-383
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    20. 20.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-324 AND SER-422;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    21. 21.
      "Structure of the elk-1-DNA complex reveals how DNA-distal residues affect ETS domain recognition of DNA."
      Mo Y. , Vaessen B. , Johnston K. , Marmorstein R.
      Nat. Struct. Biol.7:292-297(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 1-94
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