ELL ELISA Kit for Human(Homo sapiens) | EIAab.comELL ELISA Kit for Human(Homo sapiens)

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Index > Protein center > ELL(Gene name) > Human

ELL (Gene name),

RNA polymerase II elongation factor ELL (Protein name ), ELL_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

ELL(C19orf17);

Protein name:

RNA polymerase II elongation factor ELL;

Alternative:

Eleven-nineteen lysine-rich leukemia protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with EAF1 and EAF2.

Function:

Elongation factor that can increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA.

Subcellular Location:

Nucleus speckle Nucleus Cajal body Colocalizes with EAF2 to nuclear speckles. Also localized to Cajal (coiled) bodies.

Protein Attributes:

Sequence length:

621

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

621:

KLAHIKRLIA | EYDQRQLQAW | P

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:8178

SMR:

P55199

MIM:

600284

Pfam:

PF10390

String:

P55199

STRING:

9606.ENSP00000262809

UniGene:

Hs.515260

Uniprot:

P55199

FOR

ELISA Kit for Human RNA polymerase II elongation factor ELL

CLIA Kit for Human RNA polymerase II elongation factor ELL

Polyclonal Antibody for Human RNA polymerase II elongation factor ELL

Monoclonal Antibody for Human RNA polymerase II elongation factor ELL

Protein for Human RNA polymerase II elongation factor ELL

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of ELL, a gene that fuses to MLL in a t(11;19)(q23;p13.1) in acute myeloid leukemia."
Thirman M.J. , Levitan D.A. , Kobayashi H. , Simon M.C. , Rowley J.D.
Proc. Natl. Acad. Sci. U.S.A.91:12110-12114(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fetal brain.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
3.

"An RNA polymerase II elongation factor encoded by the human ELL gene."
Shilatifard A. , Lane W.S. , Jackson K.W. , Conaway R.C. , Conaway J.W.
Science271:1873-1876(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION ELONGATION
4.

"EAF1, a novel ELL-associated factor that is delocalized by expression of the MLL-ELL fusion protein."
Simone F. , Polak P.E. , Kaberlein J.J. , Luo R.T. , Levitan D.A. , Thirman M.J.
Blood98:201-209(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EAF1;SUBCELLULAR LOCATION
5.

"ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties."
Simone F. , Luo R.T. , Polak P.E. , Kaberlein J.J. , Thirman M.J.
Blood101:2355-2362(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH EAF2;SUBCELLULAR LOCATION
6.

"ELL and EAF1 are Cajal body components that are disrupted in MLL-ELL leukemia."
Polak P.E. , Simone F. , Kaberlein J.J. , Luo R.T. , Thirman M.J.
Mol. Biol. Cell14:1517-1528(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
7.

"ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL."
Kong S.E. , Banks C.A. , Shilatifard A. , Conaway J.W. , Conaway R.C.
Proc. Natl. Acad. Sci. U.S.A.102:10094-10098(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TRANSCRIPTION
8.

"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-561;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Embryonic kidney.
9.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
10.

"HIV-1 Tat and host AFF4 recruit two transcription elongation factors into a bifunctional complex for coordinated activation of HIV-1 transcription."
He N. , Liu M. , Hsu J. , Xue Y. , Chou S. , Burlingame A. , Krogan N.J. , Alber T. , Zhou Q.
Mol. Cell38:428-438(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE SEC COMPLEX
11.

"AFF4, a component of the ELL/P-TEFb elongation complex and a shared subunit of MLL chimeras, can link transcription elongation to leukemia."
Lin C. , Smith E.R. , Takahashi H. , Lai K.C. , Martin-Brown S. , Florens L. , Washburn M.P. , Conaway J.W. , Conaway R.C. , Shilatifard A.
Mol. Cell37:429-437(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE SEC COMPLEX
12.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-309;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
13.

"The little elongation complex regulates small nuclear RNA transcription."
Smith E.R. , Lin C. , Garrett A.S. , Thornton J. , Mohaghegh N. , Hu D. , Jackson J. , Saraf A. , Swanson S.K. , Seidel C. , Florens L. , Washburn M.P. , Eissenberg J.C. , Shilatifard A.
Mol. Cell44:954-965(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE SEC COMPLEX;IDENTIFICATION IN THE LEC COMPLEX;INTERACTION WITH ICE1 AND ICE2
14.

"ELL facilitates RNA polymerase II pause site entry and release."
Byun J.S. , Fufa T.D. , Wakano C. , Fernandez A. , Haggerty C.M. , Sung M.H. , Gardner K.
Nat. Commun.3:633-633(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
15.

"The super elongation complex (SEC) family in transcriptional control."
Luo Z. , Lin C. , Shilatifard A.
Nat. Rev. Mol. Cell Biol.13:543-547(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON THE SUPER ELONGATION COMPLEX
16.

"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P. , Lasa M. , Polevoda B. , Gazquez C. , Elosegui-Artola A. , Kim D.S. , De Juan-Pardo E. , Demeyer K. , Hole K. , Larrea E. , Timmerman E. , Prieto J. , Arnesen T. , Sherman F. , Gevaert K. , Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
17.

"The little elongation complex functions at initiation and elongation phases of snRNA gene transcription."
Hu D. , Smith E.R. , Garruss A.S. , Mohaghegh N. , Varberg J.M. , Lin C. , Jackson J. , Gao X. , Saraf A. , Florens L. , Washburn M.P. , Eissenberg J.C. , Shilatifard A.
Mol. Cell51:493-505(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION IN THE LEC COMPLEX;INTERACTION WITH ICE1
18.

"Solution structure of the helical domain in human eleven-nineteen lysine-rich leukemia protein ELL."
RIKEN structural genomics initiative (RSGI)
Submitted (2007-05) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 197-297

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