TCEB1 ELISA Kit for Human(Homo sapiens) | EIAab.comTCEB1 ELISA Kit for Human(Homo sapiens) | EIAab.com

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TCEB1 (Gene name),

Transcription elongation factor B polypeptide 1 (Protein name ), ELOC_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

TCEB1;

Protein name:

Transcription elongation factor B polypeptide 1;

Alternative:

Elongin-C(EloC);Elongin 15 kDa subunit;SIII p15;RNA polymerase II transcription factor SIII subunit C;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterotrimer of an A (A1, A2 or A3), B and C subunit. Part of E3 ubiquitin ligase complexes with CUL5 or CUL2, RBX1 and a substrate adapter protein that can be either SOCS1, TCEB3, VHL or WSB1 (By similarity). The elongin BC complex is part of a complex with hydroxylated HIF1A. Substrate adapter protein can be a viral protein such as HIV Vif. Interacts with VHL. Interacts with TMF1. Interacts with human respiratory syncytial virus (HRSV) protein NS1.

Function:

The elongin BC complex seems to be involved as an adapter protein in the proteasomal degradation of target proteins via different E3 ubiquitin ligase complexes, including the von Hippel-Lindau ubiquitination complex CBC(VHL). By binding to BC-box motifs it seems to link target recruitment subunits, like VHL and members of the SOCS box family, to Cullin/RBX1 modules that activate E2 ubiquitination enzymes.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

112

Sequence:

50:

MDGEEKTYGG | CEGPDAMYVK | LISSDGHEFI | VKREHALTSG | TIKAMLSGPG |

100:

QFAENETNEV | NFREIPSHVL | SKVCMYFTYK | VRYTNSSTEI | PEFPIAPEIA |

112:

LELLMAANFL | DC

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

UniGene:

String:

MIM:

Pfam:

STRING:

9606.ENSP00000284811

KEGG:

Uniprot:

FOR

ELISA Kit for Human Transcription elongation factor B polypeptide 1

ELISA Kit for Human Transcription elongation factor B polypeptide 1

ELISA Kit for Human Transcription elongation factor B polypeptide 1

ELISA Kit for Human Transcription elongation factor B polypeptide 1

CLIA Kit for Human Transcription elongation factor B polypeptide 1

CLIA Kit for Human Transcription elongation factor B polypeptide 1

CLIA Kit for Human Transcription elongation factor B polypeptide 1

CLIA Kit for Human Transcription elongation factor B polypeptide 1

Polyclonal Antibody for Human Transcription elongation factor B polypeptide 1

Polyclonal Antibody for Human Transcription elongation factor B polypeptide 1

Polyclonal Antibody for Human Transcription elongation factor B polypeptide 1

Polyclonal Antibody for Human Transcription elongation factor B polypeptide 1

Monoclonal Antibody for Human Transcription elongation factor B polypeptide 1

Monoclonal Antibody for Human Transcription elongation factor B polypeptide 1

Monoclonal Antibody for Human Transcription elongation factor B polypeptide 1

Monoclonal Antibody for Human Transcription elongation factor B polypeptide 1

Protein for Human Transcription elongation factor B polypeptide 1

Protein for Human Transcription elongation factor B polypeptide 1

Protein for Human Transcription elongation factor B polypeptide 1

Protein for Human Transcription elongation factor B polypeptide 1

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

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Gene150:413-414(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Peripheral blood.
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BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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Nature439:331-335(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
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"Drosophila von Hippel-Lindau tumor suppressor complex possesses E3 ubiquitin ligase activity."
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Biochem. Biophys. Res. Commun.276:355-361(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH VHL
6.

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Lab. Invest.82:629-637(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
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"Phosphorylation of a novel SOCS-box regulates assembly of the HIV-1 Vif-Cul5 complex that promotes APOBEC3G degradation."
Mehle A. , Goncalves J. , Santa-Marta M. , McPike M. , Gabuzda D.
Genes Dev.18:2861-2866(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIV VIF
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"TMF/ARA160 is a BC-box-containing protein that mediates the degradation of Stat3."
Perry E. , Tsruya R. , Levitsky P. , Pomp O. , Taller M. , Weisberg S. , Parris W. , Kulkarni S. , Malovani H. , Pawson T. , Shpungin S. , Nir U.
Oncogene23:8908-8919(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMF1
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN EGFR DEGRADATION;INTERACTION WITH SOCS5
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Mol. Cell24:967-976(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SPSB1
11.

"Respiratory syncytial virus NS1 protein degrades STAT2 by using the Elongin-Cullin E3 ligase."
Elliott J. , Lynch O.T. , Suessmuth Y. , Qian P. , Boyd C.R. , Burrows J.F. , Buick R. , Stevenson N.J. , Touzelet O. , Gadina M. , Power U.F. , Johnston J.A.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HRSV PROTEIN NS1
12.

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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLHDC10
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Stebbins C.E. , Kaelin W.G. Jr. , Pavletich N.P.
Science284:455-461(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 17-112 IN COMPLEX WITH 1-120 OF TCEB2 AND 54-213 OF VHL
15.

"Structural basis for the recognition of hydroxyproline in HIF-1 alpha by pVHL."
Hon W.-C. , Wilson M.I. , Harlos K. , Claridge T.D.W. , Schofield C.J. , Pugh C.W. , Maxwell P.H. , Ratcliffe P.J. , Stuart D.I. , Jones E.Y.
Nature417:975-978(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 17-112 IN COMPLEX WITH TCEB2; 52-113 OF VHL AND 549-582 OF HIF1A
16.

"Structure of an HIF-1alpha-pVHL complex: hydroxyproline recognition in signaling."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS) COMPLEX WITH TCEB2; 54-113 OF VHL AND 556-575 OF HIF1A
17.

"Structure of the SOCS4-ElonginB/C complex reveals a distinct SOCS box interface and the molecular basis for SOCS-dependent EGFR degradation."
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Structure15:1493-1504(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 17-112 IN COMPLEX WITH TCEB2 ANS SOX4;SUBUNIT

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