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Index > Protein center > Ikbkap(Gene name) > Mouse
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  • Ikbkap (Gene name),
  • Elongator complex protein 1 (Protein name ),  ELP1_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ikbkap(Elp1;Ikap);
    Protein name:
    Elongator complex protein 1(ELP1);
    Alternative:
    IkappaB kinase complex-associated protein(IKK complex-associated protein);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts preferentially with MAP3K14/NIK followed by IKK-alpha and IKK-beta. Component of the RNA polymerase II elongator complex (Elongator), which consists of IKBKAP/ELP1, STIP1/ELP2, ELP3, ELP4, and two yet unidentified proteins. Elongator associates with the C-terminal domain (CTD) of Pol II largest subunit. Interacts with ELP3.
    Function:
    Acts as subunit of the RNA polymerase II elongator complex, which is a histone acetyltransferase component of the RNA polymerase II (Pol II) holoenzyme and is involved in transcriptional elongation. Elongator may play a role in chromatin remodeling and is involved in acetylation of histones H3 and probably H4.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    1333
    Sequence:
    50:
    MRNLKLHRTL | EFRDIQAPGK | PQCFCLRAEQ | GTVLIGSERG | LTEVDPVRRE | 
    100:
    VKTEISLVAE | GFLPEDGSGC | IVGIQDLLDQ | ESVCVATASG | DVIVCNLSTQ | 
    150:
    QLECVGSVAS | GISVMSWSPD | QELLLLATAQ | QTLIMMTKDF | EVIAEEQIHQ | 
    200:
    DDFGEGKFVT | VGWGSKQTQF | HGSEGRPTAF | PVQLPENALP | WDDRRPHITW | 
    250:
    RGDGQYFAVS | VVCRQTEARK | IRVWNREFAL | QSTSESVPGL | GPALAWKPSG | 
    300:
    SLIASTQDKP | NQQDVVFFEK | NGLLHGHFTL | PFLKDEVKVN | DLLWNADSSV | 
    350:
    LAIWLEDLPK | EDSSTLKSYV | QLWTVGNYHW | YLKQSLPFST | TGKNQIVSLL | 
    400:
    WDPVTPCRLH | VLCTGWRYLC | CDWHWTTDRS | SGNSANDLAN | VAVIDGNRVL | 
    450:
    VTVFRQTVVP | PPMCTYRLLI | PHPVNQVIFS | AHLGNDLAVL | DASNQISVYK | 
    500:
    CGDKPNMDST | VKLGAVGGNG | FKVPLTTPHL | EKRYSIQFGN | NEEEEEEEVN | 
    550:
    ALQLSFLTWV | EDDTFLAISY | SHSSSQSIIH | HLTVTHSEVD | EEQGQLDVSS | 
    600:
    SVTVDGVVIG | LCCCSKTKSL | AVQLADGQVL | KYLWESPSLA | VEPWKNSEGI | 
    650:
    PVRFVHPCTQ | MEVATIGGEE | CVLGLTDRCR | FFINDTEVAS | NITSFAVCDD | 
    700:
    FLLVTTHSHT | CQVFSLSGAS | LKMLQAALSG | SHEASGEILR | KVERGSRIVT | 
    750:
    VVPQDTKLIL | QMPRGNLEVV | HHRALVLAQI | RKWLDKLMFK | EAFECMRKLR | 
    800:
    INLNLIHDHN | PKVFLENVET | FVKQIDSVNH | INLFFTELRE | EDVTKTMYPP | 
    850:
    PITKSVQVST | HPDGKKLDLI | CDAMRAAMEA | INPRKFCLSI | LTSHVKKTTP | 
    900:
    ELEIVLQKVQ | ELQGNLPFDP | ESVSVEEALK | YLLLLVDVNE | LFNHSLGTYD | 
    950:
    FNLVLMVAEK | SQKDPKEYLP | FLNTLKKMET | NYQRFTIDKY | LKRYEKALGH | 
    1000:
    LSKCGPEYFT | ECLNLIKDKN | LYKEALKLYR | PDSPQYQAVS | MAYGEHLMQE | 
    1050:
    HLYEPAGLVF | ARCGAQEKAL | EAFLACGSWQ | QALCVAAQLQ | MSKDKVAGLA | 
    1100:
    RTLAGKLVEQ | RKHSEAATVL | EQYAQDYEEA | VLLLLEGSAW | EEALRLVYKY | 
    1150:
    DRVDIIETSV | KPSILEAQKN | YMDFLDSETA | TFIRHKNRLQ | VVRALRRQAP | 
    1200:
    QVHVDHEVAH | GPESDLFSET | SSIMSGSEMS | GRYSHSNSRI | SARSSKNRRK | 
    1250:
    AERKKHSLKE | GSPLEGLALL | EALSEVVQSV | EKLKDEVRAI | LKVLFLFEFE | 
    1300:
    EQAKELQRAF | ESTLQLMERA | VPEIWTPAGQ | QSSTTPVLGP | SSTANSITAS | 
    1333:
    YQQQKTCVPA | LDAGVYMPPK | MDPRSQWKLS | LLE
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse ELP1
    ELISA Kit for Mouse ELP1
    ELISA Kit for Mouse ELP1
    ELISA Kit for Mouse ELP1
    CLIA Kit for Mouse ELP1
    CLIA Kit for Mouse ELP1
    CLIA Kit for Mouse ELP1
    CLIA Kit for Mouse ELP1
    Polyclonal Antibody for Mouse ELP1
    Polyclonal Antibody for Mouse ELP1
    Polyclonal Antibody for Mouse ELP1
    Polyclonal Antibody for Mouse ELP1
    Monoclonal Antibody for Mouse ELP1
    Monoclonal Antibody for Mouse ELP1
    Monoclonal Antibody for Mouse ELP1
    Monoclonal Antibody for Mouse ELP1
    Protein for Mouse ELP1
    Protein for Mouse ELP1
    Protein for Mouse ELP1
    Protein for Mouse ELP1

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    References
    1. 1.
      "Cloning, characterization, and genomic structure of the mouse Ikbkap gene."
      Cuajungco M.P. , Leyne M. , Mull J. , Gill S.P. , Gusella J.F. , Slaugenhaupt S.A.
      DNA Cell Biol.20:579-586(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
      strain: BALB/c.
    2. 2.
      "Genomic organization and chromosomal localization of the mouse IKBKAP gene."
      Coli R. , Anderson S.L. , Volpi S.A. , Rubin B.Y.
      Gene279:81-89(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: 129/SvJ.
      tissue: Spleen.
    3. 3.
      "Molecular cloning and biochemical analysis of murine IKAP."
      Shirane M. , Hatakeyama S. , Nakayama K.
      Submitted (1999-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6 X CBA.
    4. 4.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cerebellum.
      tissue: Head.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
      tissue: Eye.
    7. 7.
      "Elongator controls the migration and differentiation of cortical neurons through acetylation of alpha-tubulin."
      Creppe C. , Malinouskaya L. , Volvert M.L. , Gillard M. , Close P. , Malaise O. , Laguesse S. , Cornez I. , Rahmouni S. , Ormenese S. , Belachew S. , Malgrange B. , Chapelle J.P. , Siebenlist U. , Moonen G. , Chariot A. , Nguyen L.
      Cell136:551-564(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NEUROGENESIS;SUBCELLULAR LOCATION
    8. 8.
      "DERP6 (ELP5) and C3ORF75 (ELP6) regulate tumorigenicity and migration of melanoma cells as subunits of Elongator."
      Close P. , Gillard M. , Ladang A. , Jiang Z. , Papuga J. , Hawkes N. , Nguyen L. , Chapelle J.P. , Bouillenne F. , Svejstrup J. , Fillet M. , Chariot A.
      J. Biol. Chem.287:32535-32545(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
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