Protein name:
Emerin ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the inner nuclear membrane. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin (By similarity). Interacts with SUN1 and SUN2.
Function:
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C.
Subcellular Location:
Nucleus inner membrane
Single-pass membrane protein
Nucleoplasmic side
Nucleus outer membrane
Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
Protein Attributes:
50:
MDDYAVLSDT | ELAAVLRQYN | IPHGPIVGST | RKLYEKKIFE | YETQRRRLLP |
100:
PNSSSSSFSY | QFSDLDSAAV | DSDMYDLPKK | EDALLYQSKD | YNDDYYEESY |
150:
LTTKTYGEPE | SVGMSKSFRQ | PGTSLVDADT | FHHQVRDDIF | SSLEEEGKDR |
200:
ERLIYGQDSA | YQSIAHYRPI | SNVSRSSLGL | SYYPTSSTSS | VSSSSSSPSS |
250:
WLTRRAIRPE | KQAPAAALGQ | DRQVPLWGQL | LLFLVFAAFL | LFVYYSIQAE |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Mouse Emerin
ELISA Kit for Mouse Emerin
ELISA Kit for Mouse Emerin
CLIA Kit for Mouse Emerin
CLIA Kit for Mouse Emerin
CLIA Kit for Mouse Emerin
Polyclonal Antibody for Mouse Emerin
Polyclonal Antibody for Mouse Emerin
Polyclonal Antibody for Mouse Emerin
Monoclonal Antibody for Mouse Emerin
Monoclonal Antibody for Mouse Emerin
Monoclonal Antibody for Mouse Emerin
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
strain :
129 .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
ICR .
tissue :
Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
DBA/2 .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Brain .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION;TISSUE SPECIFICITY
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TMEM43;SUBCELLULAR LOCATION
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-161;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic fibroblast .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH SUN1 AND SUN2