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Index > Protein center > Emd(Gene name) > Mouse
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  • Emd (Gene name),
  • Emerin (Protein name ),  EMD_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Emd(Sta);
    Protein name:
    Emerin;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with lamins A and C, BANF1, GMCL, BCLAF1 and YTHDC1/YT521. Interacts with TMEM43; the interaction retains emerin in the inner nuclear membrane. Interacts with ACTB, SPTAN1, F-actin, CTNNB1 and beta-tubulin (By similarity). Interacts with SUN1 and SUN2.
    Function:
    Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. Required for proper localization of non-farnesylated prelamin-A/C.
    Subcellular Location:
    Nucleus inner membrane Single-pass membrane protein Nucleoplasmic side Nucleus outer membrane Colocalized with BANF1 at the central region of the assembling nuclear rim, near spindle-attachment sites. The accumulation of different intermediates of prelamin-A/C (non-farnesylated or carboxymethylated farnesylated prelamin-A/C) in fibroblasts modify its localization in the nucleus.
    Protein Attributes:
    Sequence length:
    259
    Sequence:
    50:
    MDDYAVLSDT | ELAAVLRQYN | IPHGPIVGST | RKLYEKKIFE | YETQRRRLLP | 
    100:
    PNSSSSSFSY | QFSDLDSAAV | DSDMYDLPKK | EDALLYQSKD | YNDDYYEESY | 
    150:
    LTTKTYGEPE | SVGMSKSFRQ | PGTSLVDADT | FHHQVRDDIF | SSLEEEGKDR | 
    200:
    ERLIYGQDSA | YQSIAHYRPI | SNVSRSSLGL | SYYPTSSTSS | VSSSSSSPSS | 
    250:
    WLTRRAIRPE | KQAPAAALGQ | DRQVPLWGQL | LLFLVFAAFL | LFVYYSIQAE | 
    259:
    EGNPFWMDP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    KEGG:
    SMR:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Emerin
    ELISA Kit for Mouse Emerin
    ELISA Kit for Mouse Emerin
    CLIA Kit for Mouse Emerin
    CLIA Kit for Mouse Emerin
    CLIA Kit for Mouse Emerin
    Polyclonal Antibody for Mouse Emerin
    Polyclonal Antibody for Mouse Emerin
    Polyclonal Antibody for Mouse Emerin
    Monoclonal Antibody for Mouse Emerin
    Monoclonal Antibody for Mouse Emerin
    Monoclonal Antibody for Mouse Emerin
    Protein for Mouse Emerin
    Protein for Mouse Emerin
    Protein for Mouse Emerin

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Isolation and characterization of the complete mouse emerin gene."
      Small K. , Wagener M. , Warren S.T.
      Mamm. Genome8:337-341(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];TISSUE SPECIFICITY
      strain: 129.
    2. 2.
      "cDNA sequence and analysis of the murine Emery-Dreifuss muscular dystrophy gene."
      Hawkes S.L.J. , Neville L.A. , Kennedy M.A.K. , Love D.R.
      Submitted (1996-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: ICR.
      tissue: Brain.
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: DBA/2.
    4. 4.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "Loss of A-type lamin expression compromises nuclear envelope integrity leading to muscular dystrophy."
      Sullivan T. , Escalante-Alcalde D. , Bhatt H. , Anver M. , Bhat N. , Nagashima K. , Stewart C.L. , Burke B.
      J. Cell Biol.147:913-920(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    7. 7.
      "LUMA interacts with emerin and influences its distribution at the inner nuclear membrane."
      Bengtsson L. , Otto H.
      J. Cell Sci.121:536-548(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TMEM43;SUBCELLULAR LOCATION
    8. 8.
      "Large scale localization of protein phosphorylation by use of electron capture dissociation mass spectrometry."
      Sweet S.M. , Bailey C.M. , Cunningham D.L. , Heath J.K. , Cooper H.J.
      Mol. Cell. Proteomics8:904-912(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-161;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic fibroblast.
    9. 9.
      "Mammalian SUN protein interaction networks at the inner nuclear membrane and their role in laminopathy disease processes."
      Haque F. , Mazzeo D. , Patel J.T. , Smallwood D.T. , Ellis J.A. , Shanahan C.M. , Shackleton S.
      J. Biol. Chem.285:3487-3498(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUN1 AND SUN2
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