Protein EMSY (Protein name
), EMSY_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
EMSY(GL002;C11orf30);
Protein name:
Protein EMSY;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer. Interacts with the transactivation domain of BRCA2. Interacts with the chromoshadow domain of CBX1 and with ZMYND11. Does not interact with CBX3 or CBX5.
Function:
Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2.
Subcellular Location:
Nucleus
Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
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Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;SUBCELLULAR LOCATION;INVOLVEMENT IN CANCER;INTERACTION WITH BRCA2; CBX1 AND ZMYND11;MUTAGENESIS OF 100-VAL--LEU-102 AND LEU-106
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3; 4; 5; 6 AND 7);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1082-1322 (ISOFORM 1)
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 861-1322 (ISOFORM 1)
Guo J.H.
,
Zan Q.
,
Yu L.
Submitted (2001-12) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 861-1322 (ISOFORM 2)
"A novel gene expressed in human liver non-tumor tissues." Li Y.
,
Wu T.
,
Xu S.
,
Ren S.
,
Chen Z.
,
Han Z.
Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
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Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1115-1322 (ISOFORM 1)
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1136;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-1136;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: FUNCTION IN TRANSCRIPTIONAL REGULATION;IDENTIFICATION IN A COMPLEX WITH HCFC1; MKI67; ZNF335; MATR3; HSPA8; TUBB2A; CCAR2; ASCL2; RBBP5 AND WDR5
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-207;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: GLYCOSYLATION AT SER-228; SER-236; THR-271; THR-501; THR-506; SER-557 AND THR-1120
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209 AND SER-1136;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-209;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 1-108;INTERACTION WITH ZMYND11
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Cited for: X-RAY CRYSTALLOGRAPHY (1.1 ANGSTROMS) OF 1-100;SUBUNIT
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Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 9-139 IN COMPLEX WITH CBX1
Vaild Sequence:
