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Index > Protein center > ENC1(Gene name) > Human
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  • ENC1 (Gene name),
  • Ectoderm-neural cortex protein 1 (Protein name ),  ENC1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ENC1(KLHL37;NRPB;PIG10);
    Protein name:
    Ectoderm-neural cortex protein 1(ENC-1);
    Alternative:
    Nuclear matrix protein NRP/B;Kelch-like protein 37;p53-induced gene 10 protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds to RB1. Hypophosphorylated RB1 associates with ENC1 during neuronal differentiation, while hyperphosphorylated RB1 associates with ENC1 in undifferentiating cells. Part of a complex that contains CUL3, RBX1 and ENC1.
    Function:
    Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. May be down-regulated in neuroblastoma tumors. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins.
    Subcellular Location:
    Nucleus matrix Cytoplasm cytoskeleton
    Protein Attributes:
    Sequence length:
    589
    Sequence:
    50:
    MSVSVHENRK | SRASSGSINI | YLFHKSSYAD | SVLTHLNLLR | QQRLFTDVLL | 
    100:
    HAGNRTFPCH | RAVLAACSRY | FEAMFSGGLK | ESQDSEVNFD | NSIHPEVLEL | 
    150:
    LLDYAYSSRV | IINEENAESL | LEAGDMLEFQ | DIRDACAEFL | EKNLHPTNCL | 
    200:
    GMLLLSDAHQ | CTKLYELSWR | MCLSNFQTIR | KNEDFLQLPQ | DMVVQLLSSE | 
    250:
    ELETEDERLV | YESAINWISY | DLKKRYCYLP | ELLQTVRLAL | LPAIYLMENV | 
    300:
    AMEELITKQR | KSKEIVEEAI | RCKLKILQND | GVVTSLCARP | RKTGHALFLL | 
    350:
    GGQTFMCDKL | YLVDQKAKEI | IPKADIPSPR | KEFSACAIGC | KVYITGGRGS | 
    400:
    ENGVSKDVWV | YDTLHEEWSK | AAPMLVARFG | HGSAELKHCL | YVVGGHTAAT | 
    450:
    GCLPASPSVS | LKQVEHYDPT | INKWTMVAPL | REGVSNAAVV | SAKLKLFAFG | 
    500:
    GTSVSHDKLP | KVQCYDQCEN | RWTVPATCPQ | PWRYTAAAVL | GNQIFIMGGD | 
    550:
    TEFSACSAYK | FNSETYQWTK | VGDVTAKRMS | CHAVASGNKL | YVVGGYFGIQ | 
    589:
    RCKTLDCYDP | TLDVWNSITT | VPYSLIPTAF | VSTWKHLPS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    MIM:
    SMR:
    KEGG:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human ENC-1
    ELISA Kit for Human ENC-1
    CLIA Kit for Human ENC-1
    CLIA Kit for Human ENC-1
    Polyclonal Antibody for Human ENC-1
    Polyclonal Antibody for Human ENC-1
    Monoclonal Antibody for Human ENC-1
    Monoclonal Antibody for Human ENC-1
    Protein for Human ENC-1
    Protein for Human ENC-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION BY TP53
      tissue: Colon cancer.
    2. 2.
      "Cloning of human ENC-1 and evaluation of its expression and regulation in nervous system tumors."
      Hernandez M.-C. , Andres-Barquin P.J. , Holt I. , Israel M.A.
      Exp. Cell Res.242:470-477(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "NRP/B, a novel nuclear matrix protein, associates with p110(RB) and is involved in neuronal differentiation."
      Kim T.-A. , Lim J. , Ota S. , Raja S. , Rogers R. , Rivnay B. , Avraham H. , Avraham S.
      J. Cell Biol.141:553-566(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal brain.
      tissue: Hippocampus.
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Brain.
    5. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Muscle.
    6. 7.
      "Ubiquitination of Keap1, a BTB-Kelch substrate adaptor protein for Cul3, targets Keap1 for degradation by a proteasome-independent pathway."
      Zhang D.D. , Lo S.C. , Sun Z. , Habib G.M. , Lieberman M.W. , Hannink M.
      J. Biol. Chem.280:30091-30099(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH CUL3 AND RBX1;UBIQUITINATION
    7. 8.
      "Ectodermal-neural cortex 1 down-regulates Nrf2 at the translational level."
      Wang X.J. , Zhang D.D.
      PLoS ONE4:E5492-E5492(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH KEAP1
    8. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
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