ENPP6;

Ectonucleotide pyrophosphatase/phosphodiesterase family member 6(E-NPP 6);

Glycerophosphocholine cholinephosphodiesterase(GPC-Cpde);Choline-specific glycerophosphodiester phosphodiesterase;

Pig (Sus scrofa). 

Homodimer; disulfide-linked.

Choline-specific glycerophosphodiester phosphodiesterase. The preferred substrate may be lysosphingomyelin (By similarity). Hydrolyzes lysophosphatidylcholine (LPC) to form monoacylglycerol and phosphorylcholine but not lysophosphatidic acid, showing it has a lysophospholipase C activity. Has a preference for LPC with short (12:0 and 14:0) or polyunsaturated (18:2 and 20:4) fatty acids. Also hydrolyzes glycerophosphorylcholine and sphingosylphosphorylcholine efficiently. Hydrolyzes the classical substrate for phospholipase C, p-nitrophenyl phosphorylcholine in vitro, while it does not hydrolyze the classical nucleotide phosphodiesterase substrate, p-nitrophenyl thymidine 5'-monophosphate. Does not hydrolyze diacyl phospholipids such as phosphatidylethanolamine, phosphatidylinositol, phosphatidylserine, phosphatidylglycerol and phosphatidic acid.

Cell membrane Lipid-anchor GPI-anchor

440

N/A

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PF01663