HERV-W_7q21.2 provirus ancestral Env polyprotein (Protein name
), ENW1_HUMAN from NCBI database.
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General Annotation
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Antigen Annotation
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3D
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Predicted Eptitope
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Vaild Sequence
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Gene name:
ERVW-1(ERVWE1);
Protein name:
HERV-W_7q21.2 provirus ancestral Env polyprotein;
Alternative:
Env-W;Endogenous retrovirus group W member 1;Enverin;Envelope polyprotein gPr73;HERV-W envelope protein;HERV-7q Envelope protein;Syncytin-1;Syncytin;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
The mature envelope protein (Env) consists of a trimer of SU-TM heterodimers attached probably by a labile interchain disulfide bond. Interacts with the C-type lectin CD209/DC-SIGN.
Function:
The transmembrane protein (TM) acts as a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of membranes.
Vaild Sequence:
