Epha5 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comEpha5 ELISA Kit for Rat(Rattus norvegicus)

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Epha5 (Gene name),

Ephrin type-A receptor 5 (Protein name ), EPHA5_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Epha5(Ehk-1;Ekh1;Rek7);

Protein name:

Ephrin type-A receptor 5;

Alternative:

EPH homology kinase 1(EHK-1);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses.

Function:

Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. Beside its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion.

Subcellular Location:

Cell membrane Single-pass type I membrane protein Cell projection axon Cell projection dendrite

Protein Attributes:

Sequence length:

1005

Sequence:

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1005:

QVTLE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.24569

Pfam:

PF01404

STRING:

10116.ENSRNOP00000002793

SMR:

P54757

KEGG:

rno:79208

Pfam:

PF14575

String:

P54757

Uniprot:

P54757

FOR

ELISA Kit for Rat Ephrin type-A receptor 5

CLIA Kit for Rat Ephrin type-A receptor 5

Polyclonal Antibody for Rat Ephrin type-A receptor 5

Monoclonal Antibody for Rat Ephrin type-A receptor 5

Protein for Rat Ephrin type-A receptor 5

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Ehk-1 and Ehk-2: two novel members of the Eph receptor-like tyrosine kinase family with distinctive structures and neuronal expression."
Maisonpierre P.C. , Barrezueta N.X. , Yancopoulos G.D.
Oncogene8:3277-3288(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 3; 4 AND 5)
strain: Sprague-Dawley.
tissue: Brain.
2.

"Expression and developmental regulation of Ehk-1, a neuronal Elk-like receptor tyrosine kinase in brain."
Taylor V. , Miescher G.C. , Pfarr S. , Honegger P. , Breitschopf H. , Lassmann H. , Steck A.J.
Neuroscience63:163-178(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3)
strain: Sprague-Dawley.
tissue: Brain.
3.

"Cloning of AL-1, a ligand for an Eph-related tyrosine kinase receptor involved in axon bundle formation."
Winslow J.W. , Moran P. , Valverde J. , Shih A. , Yuan J.Q. , Wong S.C. , Tsai S.P. , Goddard A. , Henzel W.J. , Hefti F. , Beck K.D. , Caras I.W.
Neuron14:973-981(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXON GUIDANCE;SUBCELLULAR LOCATION
4.

"Regulation of hippocampal synaptic plasticity by the tyrosine kinase receptor, REK7/EphA5, and its ligand, AL-1/Ephrin-A5."
Gao W.Q. , Shinsky N. , Armanini M.P. , Moran P. , Zheng J.L. , Mendoza-Ramirez J.L. , Phillips H.S. , Winslow J.W. , Caras I.W.
Mol. Cell. Neurosci.11:247-259(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYNAPTIC PLASTICITY;TISSUE SPECIFICITY
5.

"Ephrin-A5 and EphA5 interaction induces synaptogenesis during early hippocampal development."
Akaneya Y. , Sohya K. , Kitamura A. , Kimura F. , Washburn C. , Zhou R. , Ninan I. , Tsumoto T. , Ziff E.B.
PLoS ONE5:E12486-E12486(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN SYNAPTOGENESIS;EFNA5 LIGAND-BINDING;SUBCELLULAR LOCATION;PHOSPHORYLATION

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