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Index > Protein center > Epha7(Gene name) > Mouse
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  • Epha7 (Gene name),
  • Ephrin type-A receptor 7 (Protein name ),  EPHA7_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Epha7(Ebk;Ehk3;Mdk1);
    Protein name:
    Ephrin type-A receptor 7;
    Alternative:
    EPH homology kinase 3(EHK-3);Developmental kinase 1(mDK-1);Embryonic brain kinase(EBK);
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain).
    Function:
    Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.
    Subcellular Location:
    Cell membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    998
    Sequence:
    50:
    MVVQTRFPSW | IILCYIWLLG | FAHTGEAQAA | KEVLLLDSKA | QQTELEWISS | 
    100:
    PPSGWEEISG | LDENYTPIRT | YQVCQVMEPN | QNNWLRTNWI | SKGNAQRIFV | 
    150:
    ELKFTLRDCN | SLPGVLGTCK | ETFNLYYYET | DYDTGRNIRE | NLYVKIDTIA | 
    200:
    ADESFTQGDL | GERKMKLNTE | VREIGPLSKK | GFYLAFQDVG | ACIALVSVKV | 
    250:
    YYKKCWSIVE | NLAVFPDTVT | GSEFSSLVEV | RGTCVSSAEE | EAENSPRMHC | 
    300:
    SAEGEWLVPI | GKCICKAGYQ | QKGDTCEPCG | RRFYKSSSQD | LQCSRCPTHS | 
    350:
    FSDREGSSRC | ECEDGYYRAP | SDPPYVACTR | PPSAPQNLIF | NINQTTVSLE | 
    400:
    WSPPADNGGR | NDVTYRILCK | RCSWEQGECV | PCGSNIGYMP | QQTGLEDNYV | 
    450:
    TVMDLLAHAN | YTFEVEAVNG | VSDLSRSQRL | FAAVSITTGQ | AAPSQVSGVM | 
    500:
    KERVLQRSVQ | LSWQEPEHPN | GVITEYEIKY | YEKDQRERTY | STLKTKSTSA | 
    550:
    SINNLKPGTV | YVFQIRAVTA | AGYGNYSPRL | DVATLEEASG | KMFEATAVSS | 
    600:
    EQNPVIIIAV | VAVAGTIILV | FMVFGFIIGR | RHCGYSKADQ | EGDEELYFHF | 
    650:
    KFPGTKTYID | PETYEDPNRA | VHQFAKELDA | SCIKIERVIG | AGEFGEVCSG | 
    700:
    RLKLPGKRDV | AVAIKTLKVG | YTEKQRRDFL | CEASIMGQFD | HPNVVHLEGV | 
    750:
    VTRGKPVMIV | IEFMENGALD | AFLRKHDGQF | TVIQLVGMLR | GIAAGMRYLA | 
    800:
    DMGYVHRDLA | ARNILVNSNL | VCKVSDFGLS | RVIEDDPEAV | YTTTGGKIPV | 
    850:
    RWTAPEAIQY | RKFTSASDVW | SYGIVMWEVM | SYGERPYWDM | SNQDVIKAIE | 
    900:
    EGYRLPAPMD | CPAGLHQLML | DCWQKDRAER | PKFEQIVGIL | DKMIRNPSSL | 
    950:
    KTPLGTCSRP | LSPLLDQSTP | DFTAFCSVGE | WLQAIKMERY | KDNFTAAGYN | 
    998:
    SLESVARMTI | DDVMSLGITL | VGHQKKIMSS | IQTMRAQMLH | LHGTGIQV
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    SMR:
    Pfam:
    Pfam:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Ephrin type-A receptor 7
    ELISA Kit for Mouse Ephrin type-A receptor 7
    ELISA Kit for Mouse Ephrin type-A receptor 7
    ELISA Kit for Mouse Ephrin type-A receptor 7
    CLIA Kit for Mouse Ephrin type-A receptor 7
    CLIA Kit for Mouse Ephrin type-A receptor 7
    CLIA Kit for Mouse Ephrin type-A receptor 7
    CLIA Kit for Mouse Ephrin type-A receptor 7
    Polyclonal Antibody for Mouse Ephrin type-A receptor 7
    Polyclonal Antibody for Mouse Ephrin type-A receptor 7
    Polyclonal Antibody for Mouse Ephrin type-A receptor 7
    Polyclonal Antibody for Mouse Ephrin type-A receptor 7
    Monoclonal Antibody for Mouse Ephrin type-A receptor 7
    Monoclonal Antibody for Mouse Ephrin type-A receptor 7
    Monoclonal Antibody for Mouse Ephrin type-A receptor 7
    Monoclonal Antibody for Mouse Ephrin type-A receptor 7
    Protein for Mouse Ephrin type-A receptor 7
    Protein for Mouse Ephrin type-A receptor 7
    Protein for Mouse Ephrin type-A receptor 7
    Protein for Mouse Ephrin type-A receptor 7

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification of alternatively spliced mRNAs encoding variants of MDK1, a novel receptor tyrosine kinase expressed in the murine nervous system."
      Ciossek T. , Millauer B. , Ullrich A.
      Oncogene10:97-108(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];ALTERNATIVE SPLICING
      strain: BALB/c.
      tissue: Brain.
    2. 2.
      "A novel truncated variant form of Ebk/MDK1 receptor tyrosine kinase is expressed in embryonic mouse brain."
      Talukder A.H. , Muramatsu T. , Kaneda N.
      Cell Struct. Funct.22:477-485(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    3. 3.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Pituitary.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    5. 5.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "Embryo brain kinase: a novel gene of the eph/elk receptor tyrosine kinase family."
      Ellis J. , Liu Q. , Breitman M. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Tempest H.V. , Warren S. , Muir E. , Schilling H. , Fletcher F.A. , Ziegler S.F. , Rogers J.H.
      Mech. Dev.52:319-341(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 431-998 (ISOFORM 1)
      tissue: Brain.
    7. 7.
      "PDZ proteins bind, cluster, and synaptically colocalize with Eph receptors and their ephrin ligands."
      Torres R. , Firestein B.L. , Dong H. , Staudinger J. , Olson E.N. , Huganir R.L. , Bredt D.S. , Gale N.W. , Yancopoulos G.D.
      Neuron21:1453-1463(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GRIP1 AND PICK1;IDENTIFICATION OF PDZ-BINDING MOTIF
    8. 8.
      "Regulation of repulsion versus adhesion by different splice forms of an Eph receptor."
      Holmberg J. , Clarke D.L. , Frisen J.
      Nature408:203-206(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CELL ADHESION AND REPULSION (ISOFORMS 1 AND 4);EFNA5 LIGAND-BINDING;PHOSPHORYLATION;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
    9. 9.
      "Ephrin signalling controls brain size by regulating apoptosis of neural progenitors."
      Depaepe V. , Suarez-Gonzalez N. , Dufour A. , Passante L. , Gorski J.A. , Jones K.R. , Ledent C. , Vanderhaeghen P.
      Nature435:1244-1250(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN APOPTOSIS
    10. 10.
      "Opposing gradients of ephrin-As and EphA7 in the superior colliculus are essential for topographic mapping in the mammalian visual system."
      Rashid T. , Upton A.L. , Blentic A. , Ciossek T. , Knoell B. , Thompson I.D. , Drescher U.
      Neuron47:57-69(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION IN TOPOGRAPHIC MAPPING;DEVELOPMENTAL STAGE
    11. 11.
      "Dissociation of corticothalamic and thalamocortical axon targeting by an EphA7-mediated mechanism."
      Torii M. , Levitt P.
      Neuron48:563-575(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CORTICOTHALAMIC AXON GUIDANCE
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