Gene name:
Epha7 (Ebk;Ehk3;Mdk1) ;
Protein name:
Ephrin type-A receptor 7 ;
Alternative:
EPH homology kinase 3 (EHK-3) ;Developmental kinase 1 (mDK-1) ;Embryonic brain kinase (EBK) ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity). Interacts (via PDZ-binding motif) with GRIP1 and PICK1 (via PDZ domain).
Function:
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 AND MAPK3 which are phosphorylated upon activation of EPHA7. Isoform 4 which lacks the kinase domain may regulate isoform 1 adhesive properties.
Subcellular Location:
Cell membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MVVQTRFPSW | IILCYIWLLG | FAHTGEAQAA | KEVLLLDSKA | QQTELEWISS |
100:
PPSGWEEISG | LDENYTPIRT | YQVCQVMEPN | QNNWLRTNWI | SKGNAQRIFV |
150:
ELKFTLRDCN | SLPGVLGTCK | ETFNLYYYET | DYDTGRNIRE | NLYVKIDTIA |
200:
ADESFTQGDL | GERKMKLNTE | VREIGPLSKK | GFYLAFQDVG | ACIALVSVKV |
250:
YYKKCWSIVE | NLAVFPDTVT | GSEFSSLVEV | RGTCVSSAEE | EAENSPRMHC |
300:
SAEGEWLVPI | GKCICKAGYQ | QKGDTCEPCG | RRFYKSSSQD | LQCSRCPTHS |
350:
FSDREGSSRC | ECEDGYYRAP | SDPPYVACTR | PPSAPQNLIF | NINQTTVSLE |
400:
WSPPADNGGR | NDVTYRILCK | RCSWEQGECV | PCGSNIGYMP | QQTGLEDNYV |
450:
TVMDLLAHAN | YTFEVEAVNG | VSDLSRSQRL | FAAVSITTGQ | AAPSQVSGVM |
500:
KERVLQRSVQ | LSWQEPEHPN | GVITEYEIKY | YEKDQRERTY | STLKTKSTSA |
550:
SINNLKPGTV | YVFQIRAVTA | AGYGNYSPRL | DVATLEEASG | KMFEATAVSS |
600:
EQNPVIIIAV | VAVAGTIILV | FMVFGFIIGR | RHCGYSKADQ | EGDEELYFHF |
650:
KFPGTKTYID | PETYEDPNRA | VHQFAKELDA | SCIKIERVIG | AGEFGEVCSG |
700:
RLKLPGKRDV | AVAIKTLKVG | YTEKQRRDFL | CEASIMGQFD | HPNVVHLEGV |
750:
VTRGKPVMIV | IEFMENGALD | AFLRKHDGQF | TVIQLVGMLR | GIAAGMRYLA |
800:
DMGYVHRDLA | ARNILVNSNL | VCKVSDFGLS | RVIEDDPEAV | YTTTGGKIPV |
850:
RWTAPEAIQY | RKFTSASDVW | SYGIVMWEVM | SYGERPYWDM | SNQDVIKAIE |
900:
EGYRLPAPMD | CPAGLHQLML | DCWQKDRAER | PKFEQIVGIL | DKMIRNPSSL |
950:
KTPLGTCSRP | LSPLLDQSTP | DFTAFCSVGE | WLQAIKMERY | KDNFTAAGYN |
998:
SLESVARMTI | DDVMSLGITL | VGHQKKIMSS | IQTMRAQMLH | LHGTGIQV
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Chicken
ELISA Kit for Mouse Ephrin type-A receptor 7
ELISA Kit for Mouse Ephrin type-A receptor 7
ELISA Kit for Mouse Ephrin type-A receptor 7
ELISA Kit for Mouse Ephrin type-A receptor 7
CLIA Kit for Mouse Ephrin type-A receptor 7
CLIA Kit for Mouse Ephrin type-A receptor 7
CLIA Kit for Mouse Ephrin type-A receptor 7
CLIA Kit for Mouse Ephrin type-A receptor 7
Polyclonal Antibody for Mouse Ephrin type-A receptor 7
Polyclonal Antibody for Mouse Ephrin type-A receptor 7
Polyclonal Antibody for Mouse Ephrin type-A receptor 7
Polyclonal Antibody for Mouse Ephrin type-A receptor 7
Monoclonal Antibody for Mouse Ephrin type-A receptor 7
Monoclonal Antibody for Mouse Ephrin type-A receptor 7
Monoclonal Antibody for Mouse Ephrin type-A receptor 7
Monoclonal Antibody for Mouse Ephrin type-A receptor 7
Protein for Mouse Ephrin type-A receptor 7
Protein for Mouse Ephrin type-A receptor 7
Protein for Mouse Ephrin type-A receptor 7
Protein for Mouse Ephrin type-A receptor 7
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Pituitary .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Brain .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH GRIP1 AND PICK1;IDENTIFICATION OF PDZ-BINDING MOTIF
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CELL ADHESION AND REPULSION (ISOFORMS 1 AND 4);EFNA5 LIGAND-BINDING;PHOSPHORYLATION;DEVELOPMENTAL STAGE;SUBCELLULAR LOCATION
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION IN APOPTOSIS
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE;FUNCTION IN TOPOGRAPHIC MAPPING;DEVELOPMENTAL STAGE
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN CORTICOTHALAMIC AXON GUIDANCE