Protein name:
Erythropoietin receptor (EPO-R) ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Forms homodimers on EPO stimulation. The tyrosine-phosphorylated form interacts with several SH2 domain-containing proteins including LYN, the adapter protein APS, PTPN6, PTPN11, JAK2, PI3 kinases, STAT5A/B, SOCS3 and CRKL. The N-terminal SH2 domain of PTPN6 binds Tyr-453 and inhibits signaling through dephosphorylation of JAK2. APS binding also inhibits the JAK-STAT signaling. Binding to PTPN11, preferentially through the N-terminal SH2 domain, promotes mitogenesis and phosphorylation of PTPN11. Binding of JAK2 (through its N-terminal) promotes cell-surface expression. Interaction with the ubiquitin ligase NOSIP mediates EPO-induced cell proliferation. Interacts with ATXN2L and INPP5D/SHIP1.
Function:
Receptor for erythropoietin. Mediates erythropoietin-induced erythroblast proliferation and differentiation. Upon EPO stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling cascade. In some cell types, can also activate STAT1 and STAT3. May also activate LYN tyrosine kinase.
Subcellular Location:
Membrane
Single-pass type I membrane protein
Protein Attributes:
50:
MDQLRVARWP | RVSPLCLLLA | GAAWASSPSL | PDPKFESKAA | LLASRGSEEL |
100:
LCFTQRLEDL | VCFWEEAANS | GMGFNYSFSY | QLEGESRKSC | RLHQAPTVRG |
150:
SMRFWCSLPT | ADTSSFVPLE | LQVTEASGSP | RYHRIIHINE | VVLLDAPAGL |
200:
LARRAEEGSH | VVLRWLPPPG | APMTTHIRYE | VDVSAGNRAG | GTQRVEVLEG |
250:
RTECVLSNLR | GGTRYTFAVR | ARMAEPSFSG | FWSAWSEPAS | LLTASDLDPL |
300:
ILTLSLILVL | ISLLLTVLAL | LSHRRALRQK | IWPGIPSPEN | EFEGLFTTHK |
350:
GNFQLWLLQR | DGCLWWSPSS | PFPEDPPAHL | EVLSERRWGV | TQAGDAGAED |
400:
KGPLLEPVGS | ERAQDTYLVL | DEWLLPRCPC | SENLSGPGDS | VDPATMDEGS |
450:
ETSSCPSDLA | SKPRPEGTSP | SSFEYTILDP | SSKLLCPRAL | PPELPPTPPH |
500:
LKYLYLVVSD | SGISTDYSSG | GSQGVHGDSS | DGPYSHPYEN | SLVPDTEPLR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Pig
Mouse
Dog
Polyclonal Antibody for Rat EPO-R
Polyclonal Antibody for Rat EPO-R
Polyclonal Antibody for Rat EPO-R
Polyclonal Antibody for Rat EPO-R
Polyclonal Antibody for Rat EPO-R
Monoclonal Antibody for Rat EPO-R
Monoclonal Antibody for Rat EPO-R
Monoclonal Antibody for Rat EPO-R
Monoclonal Antibody for Rat EPO-R
Monoclonal Antibody for Rat EPO-R
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM EPOR-F)
tissue :
Pheochromocytoma .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS EPOR-F AND EPOR-S)
strain :
Long Evans .