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Index > Protein center > EPS8(Gene name) > Human
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  • EPS8 (Gene name),
  • Epidermal growth factor receptor kinase substrate 8 (Protein name ),  EPS8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EPS8;
    Protein name:
    Epidermal growth factor receptor kinase substrate 8;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer (By similarity). Interacts with LANCL1 (By similarity). Interacts with BAIAP2. Interacts with SHB.
    Function:
    Upon binding to EGF receptor enhances EGF-dependent mitogenic signals. Can bind multiple cellular targets.
    Subcellular Location:
    N/A
    Protein Attributes:
    Sequence length:
    822
    Sequence:
    50:
    MNGHISNHPS | SFGMYPSQMN | GYGSSPTFSQ | TDREHGSKTS | AKALYEQRKN | 
    100:
    YARDSVSSVS | DISQYRVEHL | TTFVLDRKDA | MITVDDGIRK | LKLLDAKGKV | 
    150:
    WTQDMILQVD | DRAVSLIDLE | SKNELENFPL | NTIQHCQAVM | HSCSYDSVLA | 
    200:
    LVCKEPTQNK | PDLHLFQCDE | VKANLISEDI | ESAISDSKGG | KQKRRPDALR | 
    250:
    MISNADPSIP | PPPRAPAPAP | PGTVTQVDVR | SRVAAWSAWA | ADQGDFEKPR | 
    300:
    QYHEQEETPE | MMAARIDRDV | QILNHILDDI | EFFITKLQKA | AEAFSELSKR | 
    350:
    KKNKKGKRKG | PGEGVLTLRA | KPPPPDEFLD | CFQKFKHGFN | LLAKLKSHIQ | 
    400:
    NPSAADLVHF | LFTPLNMVVQ | ATGGPELASS | VLSPLLNKDT | IDFLNYTVNG | 
    450:
    DERQLWMSLG | GTWMKARAEW | PKEQFIPPYV | PRFRNGWEPP | MLNFMGATME | 
    500:
    QDLYQLAESV | ANVAEHQRKQ | EIKRLSTEHS | SVSEYHPADG | YAFSSNIYTR | 
    550:
    GSHLDQGEAA | VAFKPTSNRH | IDRNYEPLKT | QPKKYAKSKY | DFVARNNSEL | 
    600:
    SVLKDDILEI | LDDRKQWWKV | RNASGDSGFV | PNNILDIVRP | PESGLGRADP | 
    650:
    PYTHTIQKQR | MEYGPRPADT | PPAPSPPPTP | APVPVPLPPS | TPAPVPVSKV | 
    700:
    PANITRQNSS | SSDSGGSIVR | DSQRHKQLPV | DRRKSQMEEV | QDELIHRLTI | 
    750:
    GRSAAQKKFH | VPRQNVPVIN | ITYDSTPEDV | KTWLQSKGFN | PVTVNSLGVL | 
    800:
    NGAQLFSLNK | DELRTVCPEG | ARVYSQITVQ | KAALEDSSGS | SELQEIMRRR | 
    822:
    QEKISAAASD | SGVESFDEGS | SH
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    Pfam:
    UniGene:
    MIM:
    KEGG:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Epidermal growth factor receptor kinase substrate 8
    ELISA Kit for Human Epidermal growth factor receptor kinase substrate 8
    ELISA Kit for Human Epidermal growth factor receptor kinase substrate 8
    CLIA Kit for Human Epidermal growth factor receptor kinase substrate 8
    CLIA Kit for Human Epidermal growth factor receptor kinase substrate 8
    CLIA Kit for Human Epidermal growth factor receptor kinase substrate 8
    Polyclonal Antibody for Human Epidermal growth factor receptor kinase substrate 8
    Polyclonal Antibody for Human Epidermal growth factor receptor kinase substrate 8
    Polyclonal Antibody for Human Epidermal growth factor receptor kinase substrate 8
    Monoclonal Antibody for Human Epidermal growth factor receptor kinase substrate 8
    Monoclonal Antibody for Human Epidermal growth factor receptor kinase substrate 8
    Monoclonal Antibody for Human Epidermal growth factor receptor kinase substrate 8
    Protein for Human Epidermal growth factor receptor kinase substrate 8
    Protein for Human Epidermal growth factor receptor kinase substrate 8
    Protein for Human Epidermal growth factor receptor kinase substrate 8

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Evolutionary conservation of the EPS8 gene and its mapping to human chromosome 12q23-q24."
      Wong W.T. , Carlomagno F. , Druck T. , Barletta C. , Croce C.M. , Huebner K. , Kraus M.H. , di Fiore P.P.
      Oncogene9:3057-3061(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Placenta.
      tissue: Testis.
      tissue: Tongue.
      tissue: Trachea.
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    6. 6.
      "Molecular interactions of the Src homology 2 domain protein Shb with phosphotyrosine residues, tyrosine kinase receptors and Src homology 3 domain proteins."
      Karlsson T. , Songyang Z. , Landgren E. , Lavergne C. , Di Fiore P.P. , Anafi M. , Pawson T. , Cantley L.C. , Claesson-Welsh L. , Welsh M.
      Oncogene10:1475-1483(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHB
    7. 7.
      "Overexpression of p97Eps8 leads to cellular transformation: implication of pleckstrin homology domain in p97Eps8-mediated ERK activation."
      Maa M.C. , Hsieh C.Y. , Leu T.H.
      Oncogene20:106-112(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    8. 8.
      "IRSp53/Eps8 complex is important for positive regulation of Rac and cancer cell motility/invasiveness."
      Funato Y. , Terabayashi T. , Suenaga N. , Seiki M. , Takenawa T. , Miki H.
      Cancer Res.64:5237-5244(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAIAP2
    9. 9.
      "Eps8 controls actin-based motility by capping the barbed ends of actin filaments."
      Disanza A. , Carlier M.F. , Stradal T.E. , Didry D. , Frittoli E. , Confalonieri S. , Croce A. , Wehland J. , Di Fiore P.P. , Scita G.
      Nat. Cell Biol.6:1180-1188(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Regulation of cell shape by Cdc42 is mediated by the synergic actin-bundling activity of the Eps8-IRSp53 complex."
      Disanza A. , Mantoani S. , Hertzog M. , Gerboth S. , Frittoli E. , Steffen A. , Berhoerster K. , Kreienkamp H.J. , Milanesi F. , Di Fiore P.P. , Ciliberto A. , Stradal T.E. , Scita G.
      Nat. Cell Biol.8:1337-1347(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 12.
      "Eps8 is increased in pancreatic cancer and required for dynamic actin-based cell protrusions and intercellular cytoskeletal organization."
      Welsch T. , Endlich K. , Giese T. , Buchler M.W. , Schmidt J.
      Cancer Lett.255:205-218(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    13. 13.
      "Eps8 decreases chemosensitivity and affects survival of cervical cancer patients."
      Chen Y.J. , Shen M.R. , Chen Y.J. , Maa M.C. , Leu T.H.
      Mol. Cancer Ther.7:1376-1385(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-476;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    15. 15.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    16. 16.
      "Epidermal growth factor receptor pathway substrate 8 is overexpressed in human pituitary tumors: role in proliferation and survival."
      Xu M. , Shorts-Cary L. , Knox A.J. , Kleinsmidt-DeMasters B. , Lillehei K. , Wierman M.E.
      Endocrinology150:2064-2071(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    17. 17.
      "Upregulation of Eps8 in oral squamous cell carcinoma promotes cell migration and invasion through integrin-dependent Rac1 activation."
      Yap L.F. , Jenei V. , Robinson C.M. , Moutasim K. , Benn T.M. , Threadgold S.P. , Lopes V. , Wei W. , Thomas G.J. , Paterson I.C.
      Oncogene28:2524-2534(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CANCER
    18. 18.
      "Solution structure of the C-terminal SAM-domain of epidermal growth receptor pathway substrate 8."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2007-07) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 699-788
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