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Index > Protein center > Ercc6l(Gene name) > Mouse
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  • Ercc6l (Gene name),
  • DNA excision repair protein ERCC-6-like (Protein name ),  ERC6L_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Ercc6l;
    Protein name:
    DNA excision repair protein ERCC-6-like;
    Alternative:
    ATP-dependent helicase ERCC6-like;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization.
    Function:
    DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
    Subcellular Location:
    Chromosome centromere Chromosome centromere kinetochore Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.
    Protein Attributes:
    Sequence length:
    1240
    Sequence:
    50:
    MEASQGLAEV | ETLSPQLAES | YLRYVQEAKE | AAKNGDLEES | LKLFNLAKDI | 
    100:
    FPTKKVMSRI | QKLQEALEQL | AEEEDDDEFI | DVCSSGLLLY | RELYEKLFEH | 
    150:
    QKEGIAFLYS | LYKDGRKGGI | LADDMGLGKT | VQIIAFLSGM | FDASLVNHVL | 
    200:
    LIMPTNLINT | WVNEFAKWTP | GMRVKTFHGS | SKSERTRSLT | RIQQRNGVVI | 
    250:
    TTYQMLLNNW | QQLASFNGQA | FVWDYVILDE | AHKIKSASTK | SAVCARAIPA | 
    300:
    SNRLLLTGTP | VQNNLQELWS | LFDFACQGSL | LGTLKTFKME | YEHPIIRARE | 
    350:
    KDATPGEKAL | GLKISENLME | IIKPYFLRRT | KEEVQTKKAD | NPEARLGEKN | 
    400:
    PAGEAICDMF | SLARKNDLIV | WIRLLPLQEE | IYRKFVSLDH | IKELLMETRS | 
    450:
    PLAELGVLKK | LCDHPRLLSA | RACRLLNLGT | ATFSAQDENE | QEDVSNMNSI | 
    500:
    DHLPDKTLIQ | ESGKMIFLMS | LLERLQDEGH | QTLVFSQSIK | ILNIIERLLK | 
    550:
    NKHFKTLRID | GTVTHLWERE | KRIQLFQQNK | EYSVFLLTTQ | VGGVGLTLTA | 
    600:
    ATRVVIFDPS | WNPATDAQAV | DRVYRIGQKE | NVVVYRLITC | GTVEEKIYRR | 
    650:
    QVFKDSLIRQ | TTGEKKNPFR | YFTKQELKEL | FTVGDLQKSA | TQMQLQCLHA | 
    700:
    AQRRSDEKLD | EHIAYLHLLG | IAGISDHDLM | FTRDLSVKEE | LDMLEDSQYI | 
    750:
    HQRVQKAQFL | VESESQNTVQ | RQTTGIEETW | LKAQEFPSQQ | KKKGTEFNKP | 
    800:
    QPQPSRLLTK | PTQVEAISSQ | MASITICDQS | AESEPQEHSE | VHDVTSLQGS | 
    850:
    HHFNSTSDAG | TIASLPQGAE | SIGEVSTDSL | LSPAKGFAAE | NDAMQKKGLQ | 
    900:
    ASPGQEAPSE | NLGSFHYLPR | ESSKASLGPN | LDLQDSVVLY | HRSPTANENQ | 
    950:
    NLESDVPMIE | ISDDLSEPPS | ALQGAQAIEA | QLELKEDDPL | KSPPQYACDF | 
    1000:
    NLFLEDSADT | RQNLSSKFLE | HVEKEKSLQS | PAANSRAKSA | LTLSLDSSPK | 
    1050:
    SDEESEVISV | KTKSKTRRIL | SDDEDEDEED | AFKGSHTNSI | NISPFPFSSV | 
    1100:
    KQFDASTPQS | GSNPSRRFFS | PKTPGEVNTS | LHSRRSLASR | RSLINVVLDD | 
    1150:
    VEDMEERLDN | SSEEESEPGL | SEENNEEEAL | ACTEEQPSGA | TLASGNKSSN | 
    1200:
    LTMSEPTSPA | PQSSPCAPEP | SSSDPMPDPP | QDLAVEAGND | YESLVARGKE | 
    1240:
    LKECGKIQEA | LNCLVKALDI | KSADPEVMLM | TLSLYKQLNI | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse DNA excision repair protein ERCC-6-like
    ELISA Kit for Mouse DNA excision repair protein ERCC-6-like
    ELISA Kit for Mouse DNA excision repair protein ERCC-6-like
    CLIA Kit for Mouse DNA excision repair protein ERCC-6-like
    CLIA Kit for Mouse DNA excision repair protein ERCC-6-like
    CLIA Kit for Mouse DNA excision repair protein ERCC-6-like
    Polyclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
    Polyclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
    Polyclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
    Monoclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
    Monoclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
    Monoclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
    Protein for Mouse DNA excision repair protein ERCC-6-like
    Protein for Mouse DNA excision repair protein ERCC-6-like
    Protein for Mouse DNA excision repair protein ERCC-6-like

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    Linearity
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    References
    1. 1.
      "cDNA cloning and expression analysis of mouse gene encoding the protein Ercc6l which is a novel member of SNF2 family."
      Chen X.-G. , Li Y. , Zang M.-X. , Pei X.-R. , Xu Y.-J. , Fang L.-F.
      Sheng Wu Hua Xue Yu Sheng Wu Wu Li Jin Zhan31:443-448(2004)
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: BALB/c.
      tissue: Heart.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
      tissue: Heart.
      tissue: Skin.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: FVB/N.
      tissue: Mammary tumor.
    5. 5.
      "Ercc6l, a gene of SNF2 family, may play a role in the teratogenic action of alcohol."
      Xu Y.-J. , Chen X.-G. , Li Y.
      Toxicol. Lett.157:233-239(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1021;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Liver.
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