Protein name:
DNA excision repair protein ERCC-6-like ;
Alternative:
ATP-dependent helicase ERCC6-like ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with PLK1, which phosphorylates it. Both proteins are mutually dependent on each other for correct subcellular localization.
Function:
DNA helicase that acts as an essential component of the spindle assembly checkpoint. Contributes to the mitotic checkpoint by recruiting MAD2 to kinetochores and monitoring tension on centromeric chromatin. Acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase.
Subcellular Location:
Chromosome
centromere
Chromosome
centromere
kinetochore
Localizes to kinetochores, inner centromeres and thin threads connecting separating chromosomes even during anaphase. In prometaphase cells, it mostly concentrates in between kinetochores. In metaphase, it localizes to numerous thin threads that stretch between sister kinetochores of the aligned chromosomes and are composed of catenated centromeric DNA. Evolution from inner centromeres to thin threads takes place in response to tension. Resolution of thin threads requires topoisomerase 2-alpha (TOP2A) after anaphase onset.
Protein Attributes:
50:
MEASQGLAEV | ETLSPQLAES | YLRYVQEAKE | AAKNGDLEES | LKLFNLAKDI |
100:
FPTKKVMSRI | QKLQEALEQL | AEEEDDDEFI | DVCSSGLLLY | RELYEKLFEH |
150:
QKEGIAFLYS | LYKDGRKGGI | LADDMGLGKT | VQIIAFLSGM | FDASLVNHVL |
200:
LIMPTNLINT | WVNEFAKWTP | GMRVKTFHGS | SKSERTRSLT | RIQQRNGVVI |
250:
TTYQMLLNNW | QQLASFNGQA | FVWDYVILDE | AHKIKSASTK | SAVCARAIPA |
300:
SNRLLLTGTP | VQNNLQELWS | LFDFACQGSL | LGTLKTFKME | YEHPIIRARE |
350:
KDATPGEKAL | GLKISENLME | IIKPYFLRRT | KEEVQTKKAD | NPEARLGEKN |
400:
PAGEAICDMF | SLARKNDLIV | WIRLLPLQEE | IYRKFVSLDH | IKELLMETRS |
450:
PLAELGVLKK | LCDHPRLLSA | RACRLLNLGT | ATFSAQDENE | QEDVSNMNSI |
500:
DHLPDKTLIQ | ESGKMIFLMS | LLERLQDEGH | QTLVFSQSIK | ILNIIERLLK |
550:
NKHFKTLRID | GTVTHLWERE | KRIQLFQQNK | EYSVFLLTTQ | VGGVGLTLTA |
600:
ATRVVIFDPS | WNPATDAQAV | DRVYRIGQKE | NVVVYRLITC | GTVEEKIYRR |
650:
QVFKDSLIRQ | TTGEKKNPFR | YFTKQELKEL | FTVGDLQKSA | TQMQLQCLHA |
700:
AQRRSDEKLD | EHIAYLHLLG | IAGISDHDLM | FTRDLSVKEE | LDMLEDSQYI |
750:
HQRVQKAQFL | VESESQNTVQ | RQTTGIEETW | LKAQEFPSQQ | KKKGTEFNKP |
800:
QPQPSRLLTK | PTQVEAISSQ | MASITICDQS | AESEPQEHSE | VHDVTSLQGS |
850:
HHFNSTSDAG | TIASLPQGAE | SIGEVSTDSL | LSPAKGFAAE | NDAMQKKGLQ |
900:
ASPGQEAPSE | NLGSFHYLPR | ESSKASLGPN | LDLQDSVVLY | HRSPTANENQ |
950:
NLESDVPMIE | ISDDLSEPPS | ALQGAQAIEA | QLELKEDDPL | KSPPQYACDF |
1000:
NLFLEDSADT | RQNLSSKFLE | HVEKEKSLQS | PAANSRAKSA | LTLSLDSSPK |
1050:
SDEESEVISV | KTKSKTRRIL | SDDEDEDEED | AFKGSHTNSI | NISPFPFSSV |
1100:
KQFDASTPQS | GSNPSRRFFS | PKTPGEVNTS | LHSRRSLASR | RSLINVVLDD |
1150:
VEDMEERLDN | SSEEESEPGL | SEENNEEEAL | ACTEEQPSGA | TLASGNKSSN |
1200:
LTMSEPTSPA | PQSSPCAPEP | SSSDPMPDPP | QDLAVEAGND | YESLVARGKE |
1240:
LKECGKIQEA | LNCLVKALDI | KSADPEVMLM | TLSLYKQLNI |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Bovine
Human
ELISA Kit for Mouse DNA excision repair protein ERCC-6-like
ELISA Kit for Mouse DNA excision repair protein ERCC-6-like
ELISA Kit for Mouse DNA excision repair protein ERCC-6-like
CLIA Kit for Mouse DNA excision repair protein ERCC-6-like
CLIA Kit for Mouse DNA excision repair protein ERCC-6-like
CLIA Kit for Mouse DNA excision repair protein ERCC-6-like
Polyclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
Polyclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
Polyclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
Monoclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
Monoclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
Monoclonal Antibody for Mouse DNA excision repair protein ERCC-6-like
Protein for Mouse DNA excision repair protein ERCC-6-like
Protein for Mouse DNA excision repair protein ERCC-6-like
Protein for Mouse DNA excision repair protein ERCC-6-like
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
BALB/c .
tissue :
Heart .
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[
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Heart .
tissue :
Skin .
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PLoS Biol.7:E1000112-E1000112(2009)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
C57BL/6J .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
FVB/N .
tissue :
Mammary tumor .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1021;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Liver .