Ercc8 ELISA Kit for Mouse(Mus musculus) | EIAab.comErcc8 ELISA Kit for Mouse(Mus musculus)

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Ercc8 (Gene name),

DNA excision repair protein ERCC-8 (Protein name ), ERCC8_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Ercc8(Ckn1;Csa);

Protein name:

DNA excision repair protein ERCC-8;

Alternative:

Cockayne syndrome WD repeat protein CSA homolog;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Part of the CSA complex (DCX(ERCC8) complex), a DCX E3 ubiquitin-protein ligase complex containing ERCC8, RBX1, DDB1 and CUL4A; the CSA complex interacts with RNA polymerase II; upon UV irradiation it interacts with the COP9 signalosome and preferentially with the hyperphosphorylated form of RNA polymerase II (By similarity). Interacts with ERCC6 (By similarity). Interacts with a subunit of RNA polymerase II TFIIH (By similarity). Interacts with DDB1.

Function:

Involved in transcription-coupled nucleotide excision repair (By similarity). It is required for the recruitement of XAB2, HMGN1 and TCEA1/TFIIS to a transcription-coupled repair complex which removes RNA polymerase II-blocking lesions from the transcribed strand of active genes (By similarity). It is the substrate-recognition component of the CSA complex (DCX(ERCC8) complex) which promotes the ubiquitination and subsequent proteasomal degradation of ERCC6 in a UV-dependent manner; ERCC6 degradation is essential for the recovery of RNA synthesis after transcription-coupled repair.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

397

Sequence:

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