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Index > Protein center > ERLIN1(Gene name) > Human
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  • ERLIN1 (Gene name),
  • Erlin-1 (Protein name ),  ERLN1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ERLIN1(C10orf69;KE04;KEO4;SPFH1);
    Protein name:
    Erlin-1;
    Alternative:
    Protein KE04;Endoplasmic reticulum lipid raft-associated protein 1;Stomatin-prohibitin-flotillin-HflC/K domain-containing protein 1(SPFH domain-containing protein 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Forms a heteromeric complex with ERLIN2.
    Function:
    Component of the ERLIN1/ERLIN2 complex which mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs).
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type II membrane protein Associated with lipid raft-like domains of the endoplasmic reticulum membrane.
    Protein Attributes:
    Sequence length:
    346
    Sequence:
    50:
    MTQARVLVAA | VVGLVAVLLY | ASIHKIEEGH | LAVYYRGGAL | LTSPSGPGYH | 
    100:
    IMLPFITTFR | SVQTTLQTDE | VKNVPCGTSG | GVMIYIDRIE | VVNMLAPYAV | 
    150:
    FDIVRNYTAD | YDKTLIFNKI | HHELNQFCSA | HTLQEVYIEL | FDQIDENLKQ | 
    200:
    ALQKDLNLMA | PGLTIQAVRV | TKPKIPEAIR | RNFELMEAEK | TKLLIAAQKQ | 
    250:
    KVVEKEAETE | RKKAVIEAEK | IAQVAKIRFQ | QKVMEKETEK | RISEIEDAAF | 
    300:
    LAREKAKADA | EYYAAHKYAT | SNKHKLTPEY | LELKKYQAIA | SNSKIYFGSN | 
    346:
    IPNMFVDSSC | ALKYSDIRTG | RESSLPSKEA | LEPSGENVIQ | NKESTG
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    String:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Erlin-1
    ELISA Kit for Human Erlin-1
    CLIA Kit for Human Erlin-1
    CLIA Kit for Human Erlin-1
    Polyclonal Antibody for Human Erlin-1
    Polyclonal Antibody for Human Erlin-1
    Monoclonal Antibody for Human Erlin-1
    Monoclonal Antibody for Human Erlin-1
    Protein for Human Erlin-1
    Protein for Human Erlin-1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Identification and characterization of a novel gene KE04 differentially expressed by activated human dendritic cells."
      Li N. , Huang X. , Zhao Z. , Chen G. , Zhang W. , Cao X.
      Biochem. Biophys. Res. Commun.279:487-493(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SUBCELLULAR LOCATION;TISSUE SPECIFICITY
      tissue: Dendritic cell.
    2. 2.
      Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
      Submitted (2005-04) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Adipose tissue.
    3. 3.
      "The DNA sequence and comparative analysis of human chromosome 10."
      Deloukas P. , Earthrowl M.E. , Grafham D.V. , Rubenfield M. , French L. , Steward C.A. , Sims S.K. , Jones M.C. , Searle S. , Scott C. , Howe K. , Hunt S.E. , Andrews T.D. , Gilbert J.G.R. , Swarbreck D. , Ashurst J.L. , Taylor A. , Battles J. , more...
      Nature429:375-381(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Brain.
    6. 6.
      "An endoplasmic reticulum (ER) membrane complex composed of SPFH1 and SPFH2 mediates the ER-associated degradation of inositol 1,4,5-trisphosphate receptors."
      Pearce M.M.P. , Wormer D.B. , Wilkens S. , Wojcikiewicz R.J.H.
      J. Biol. Chem.284:10433-10445(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE;FUNCTION;SUBUNIT;SUBCELLULAR LOCATION;GLYCOSYLATION;INTERACTION WITH ERLIN2
    7. 7.
      "Erlin-1 and erlin-2 are novel members of the prohibitin family of proteins that define lipid-raft-like domains of the ER."
      Browman D.T. , Resek M.E. , Zajchowski L.D. , Robbins S.M.
      J. Cell Sci.119:3149-3160(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
      J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-106
      tissue: Liver.
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-267;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      "RNF170 protein, an endoplasmic reticulum membrane ubiquitin ligase, mediates inositol 1,4,5-trisphosphate receptor ubiquitination and degradation."
      Lu J.P. , Wang Y. , Sliter D.A. , Pearce M.M. , Wojcikiewicz R.J.
      J. Biol. Chem.286:24426-24433(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF170
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