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Index > Protein center > ERN2(Gene name) > Human
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  • ERN2 (Gene name),
  • Serine/threonine-protein kinase/endoribonuclease IRE2 (Protein name ),  ERN2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ERN2(IRE2);
    Protein name:
    Serine/threonine-protein kinase/endoribonuclease IRE2;
    Alternative:
    Inositol-requiring protein 2(hIRE2p);Endoplasmic reticulum-to-nucleus signaling 2;Ire1-beta(IRE1b);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Induces translational repression through 28S ribosomal RNA cleavage in response to ER stress. Pro-apoptotic. Appears to play no role in the unfolded-protein response, unlike closely related proteins.
    Subcellular Location:
    Endoplasmic reticulum membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    926
    Sequence:
    50:
    MASAVRGSRP | WPRLGLQLQF | AALLLGTLSP | QVHTLRPENL | LLVSTLDGSL | 
    100:
    HALSKQTGDL | KWTLRDDPVI | EGPMYVTEMA | FLSDPADGSL | YILGTQKQQG | 
    150:
    LMKLPFTIPE | LVHASPCRSS | DGVFYTGRKQ | DAWFVVDPES | GETQMTLTTE | 
    200:
    GPSTPRLYIG | RTQYTVTMHD | PRAPALRWNT | TYRRYSAPPM | DGSPGKYMSH | 
    250:
    LASCGMGLLL | TVDPGSGTVL | WTQDLGVPVM | GVYTWHQDGL | RQLPHLTLAR | 
    300:
    DTLHFLALRW | GHIRLPASGP | RDTATLFSTL | DTQLLMTLYV | GKDETGFYVS | 
    350:
    KALVHTGVAL | VPRGLTLAPA | DGPTTDEVTL | QVSGEREGSP | STAVRYPSGS | 
    400:
    VALPSQWLLI | GHHELPPVLH | TTMLRVHPTL | GSGTAETRPP | ENTQAPAFFL | 
    450:
    ELLSLSREKL | WDSELHPEEK | TPDSYLGLGP | QDLLAASLTA | VLLGGWILFV | 
    500:
    MRQQQPQVVE | KQQETPLAPA | DFAHISQDAQ | SLHSGASRRS | QKRLQSPSKQ | 
    550:
    AQPLDDPEAE | QLTVVGKISF | NPKDVLGRGA | GGTFVFRGQF | EGRAVAVKRL | 
    600:
    LRECFGLVRR | EVQLLQESDR | HPNVLRYFCT | ERGPQFHYIA | LELCRASLQE | 
    650:
    YVENPDLDRG | GLEPEVVLQQ | LMSGLAHLHS | LHIVHRDLKP | GNILITGPDS | 
    700:
    QGLGRVVLSD | FGLCKKLPAG | RCSFSLHSGI | PGTEGWMAPE | LLQLLPPDSP | 
    750:
    TSAVDIFSAG | CVFYYVLSGG | SHPFGDSLYR | QANILTGAPC | LAHLEEEVHD | 
    800:
    KVVARDLVGA | MLSPLPQPRP | SAPQVLAHPF | FWSRAKQLQF | FQDVSDWLEK | 
    850:
    ESEQEPLVRA | LEAGGCAVVR | DNWHEHISMP | LQTDLRKFRS | YKGTSVRDLL | 
    900:
    RAVRNKKHHY | RELPVEVRQA | LGQVPDGFVQ | YFTNRFPRLL | LHTHRAMRSC | 
    926:
    ASESLFLPYY | PPDSEARRPC | PGATGR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    KEGG:
    Pfam:
    SMR:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    ELISA Kit for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    CLIA Kit for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    CLIA Kit for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    Polyclonal Antibody for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    Polyclonal Antibody for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    Monoclonal Antibody for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    Monoclonal Antibody for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    Protein for Human Serine/threonine-protein kinase/endoribonuclease IRE2
    Protein for Human Serine/threonine-protein kinase/endoribonuclease IRE2

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Translational control by the ER transmembrane kinase/ribonuclease IRE1 under ER stress."
      Iwawaki T. , Hosoda A. , Okuda T. , Kamigori Y. , Nomura-Furuwatari C. , Kimata Y. , Tsuru A. , Kohno K.
      Nat. Cell Biol.3:158-164(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;GLYCOSYLATION;AUTOPHOSPHORYLATION;MUTAGENESIS OF LYS-548;VARIANTS GLN-271 AND THR-487
      tissue: Fetal lung fibroblast.
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Fetal brain.
    3. 3.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "Patterns of somatic mutation in human cancer genomes."
      Greenman C. , Stephens P. , Smith R. , Dalgliesh G.L. , Hunter C. , Bignell G. , Davies H. , Teague J. , Butler A. , Stevens C. , Edkins S. , O'Meara S. , Vastrik I. , Schmidt E.E. , Avis T. , Barthorpe S. , Bhamra G. , Buck G. , more...
      Nature446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-69; CYS-118; CYS-184; GLN-271; THR-318; PHE-410; THR-487; PHE-504; GLN-537 AND TYR-858
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