Protein name:
ERO1-like protein alpha (ERO1-L;ERO1-L-alpha) ;
Alternative:
Oxidoreductin-1-L-alpha ;Endoplasmic oxidoreductin-1-like protein ;
Organism:
Pig (Sus scrofa).
General Annotation
Sub Unit:
Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT.
Function:
Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins.
Subcellular Location:
Endoplasmic reticulum membrane
Peripheral membrane protein
Lumenal side
The association with ERP44 is essential for its retention in the endoplasmic reticulum.
Protein Attributes:
50:
MGHRWGFLIV | FLGAVGLLGS | GYGRQQPSET | AAQRCFCQVS | GYLDDCTCDV |
100:
ETIDRFNNYR | LFPRLQKLLE | SDYFRYYKVN | LKRPCPFWND | INQCGRRDCA |
150:
VKPCQSDEIP | DGIKSASYKY | SEEANNLIEE | CEQAERLGAV | DESLSEETQK |
200:
AVLQWTKHDD | SSDNFCEADD | IQSPDAEYVD | LLLNPERYTG | YKGPDAWKIW |
250:
NVIYEENCFK | PQTIKRPLNP | LASGQGKSEE | NTFYSWLEGL | CVEKRAFYRL |
300:
ISGLHASINV | HLSARYLLQD | TWLEKKWGHN | ITEFQQRFDG | ILTEGEGPRR |
350:
LKNLYFLYLI | ELRALSKVVP | FFERPDFQLF | TGNKVQDAEN | KMLLLDILHE |
400:
IKSFPLHFDE | NSFFAGDKKE | ANKLKEDFRL | HFRNISRIMD | CVGCLKCRLW |
450:
GKLQTQGLGT | ALKILFSEKL | IANMPESGPS | YEFHLTRQEI | VSLFNAFGRI |
468:
STSVKELENF | RNLLQNIH
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Pig
Mouse
Bovine
Rat
Human
Polyclonal Antibody for Pig ERO1-L
Polyclonal Antibody for Pig ERO1-L
Polyclonal Antibody for Pig ERO1-L
Polyclonal Antibody for Pig ERO1-L
Polyclonal Antibody for Pig ERO1-L
Monoclonal Antibody for Pig ERO1-L
Monoclonal Antibody for Pig ERO1-L
Monoclonal Antibody for Pig ERO1-L
Monoclonal Antibody for Pig ERO1-L
Monoclonal Antibody for Pig ERO1-L
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
Long Q.
,
Yang Z.
Submitted (2008-03) to the EMBL/GenBank/DDBJ databases
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Cited for : NUCLEOTIDE SEQUENCE [MRNA]