Ero1l ELISA Kit for Rat(Rattus norvegicus) | EIAab.comEro1l ELISA Kit for Rat(Rattus norvegicus)

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Ero1l (Gene name),

ERO1-like protein alpha (Protein name ), ERO1A_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Ero1l(Giig11);

Protein name:

ERO1-like protein alpha(ERO1-L;ERO1-L-alpha);

Alternative:

Global ischemia-induced protein 11;Endoplasmic oxidoreductin-1-like protein;Oxidoreductin-1-L-alpha;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Predominantly monomer. May function both as a monomer and a homodimer. Interacts with PDILT.

Function:

Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on P4HB/PDI to transfer oxidizing equivalent. Associates with ERP44 but not with GRP54, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress. Required for the folding of immunoglobulin proteins.

Subcellular Location:

Endoplasmic reticulum membrane Peripheral membrane protein Lumenal side The association with ERP44 is essential for its retention in the endoplasmic reticulum (By similarity). In neurons, it localizes to dendrites.

Protein Attributes:

Sequence length:

464

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

464:

RELENFRHLL | QNVH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.64648

KEGG:

rno:171562

Pfam:

PF04137

String:

Q8R4A1

Uniprot:

Q8R4A1

FOR

ELISA Kit for Rat ERO1-L

CLIA Kit for Rat ERO1-L

Polyclonal Antibody for Rat ERO1-L

Monoclonal Antibody for Rat ERO1-L

Protein for Rat ERO1-L

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Ero1-L, an ischemia-inducible gene from rat brain with homology to global ischemia-induced gene 11 (Giig11), is localized to neuronal dendrites by a dispersed identifier (ID) element-dependent mechanism."
Chen D. , Jin K. , Kawaguchi K. , Nakayama M. , Zhou X. , Xiong Z. , Zhou A. , Mao X.O. , Greenberg D.A. , Graham S.H. , Simon R.P.
J. Neurochem.85:670-679(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);SUBCELLULAR LOCATION;INDUCTION
strain: Sprague-Dawley.
tissue: Brain.
2.

"Cloning of the two forms of Ero1, alpha and beta and their regulation in cultured thyrocytes."
Li B. , Abplanalp W.A. , Kim P.S.
Submitted (2002-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Thyroid.
3.

"The cellular oxygen tension regulates expression of the endoplasmic oxidoreductase ERO1-Lalpha."
Gess B. , Hofbauer K.H. , Wenger R.H. , Lohaus C. , Meyer H.E. , Kurtz A.
Eur. J. Biochem.270:2228-2235(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;INDUCTION

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