Gene name:
Erp44 (Kiaa0573;Txndc4) ;
Protein name:
Endoplasmic reticulum resident protein 44 (ER protein 44;ERp44) ;
Alternative:
Thioredoxin domain-containing protein 4 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms mixed disulfides with both ERO1L and ERO1LB and cargo folding intermediates (By similarity). Directly interacts with ITPR1 in a pH-, redox state- and calcium-dependent manner, but not with ITPR2 or ITPR3. The strength of this interaction inversely correlates with calcium concentration.
Function:
Mediates thiol-dependent retention in the early secretory pathway, forming mixed disulfides with substrate proteins through its conserved CRFS motif. Inhibits the calcium channel activity of ITPR1. May have a role in the control of oxidative protein folding in the endoplasmic reticulum. Required to retain ERO1L and ERO1LB in the endoplasmic reticulum.
Subcellular Location:
Endoplasmic reticulum lumen
Protein Attributes:
50:
MNPAVFLSLA | DLRCSLLLLV | TSIFTPITAE | IASLDSENID | EILNNADVAL |
100:
VNFYADWCRF | SQMLHPIFEE | ASDVIKEEYP | DKNQVVFARV | DCDQHSDIAQ |
150:
RYRISKYPTL | KLFRNGMMMK | REYRGQRSVK | ALADYIRQQK | SNPVHEIQSL |
200:
DEVTNLDRSK | RNIIGYFEQK | DSENYRVFER | VASILHDDCA | FLSAFGDLSK |
250:
PERYNGDNVI | YKPPGRSAPD | MVYLGSMTNF | DVTYNWIQDK | CVPLVREITF |
300:
ENGEELTEEG | LPFLILFHMK | DDTESLEIFQ | NEVARQLISE | KGTINFLHAD |
350:
CDKFRHPLLH | IQKTPADCPV | IAIDSFRHMY | VFGDFKDVLI | PGKLKQFVFD |
400:
LHSGKLHREF | HHGPDPTDTA | PGEQDQDVAS | SPPESSFQKL | APSEYRYTLL |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
ELISA Kit for Mouse ER protein 44
ELISA Kit for Mouse ER protein 44
ELISA Kit for Mouse ER protein 44
CLIA Kit for Mouse ER protein 44
CLIA Kit for Mouse ER protein 44
CLIA Kit for Mouse ER protein 44
Polyclonal Antibody for Mouse ER protein 44
Polyclonal Antibody for Mouse ER protein 44
Polyclonal Antibody for Mouse ER protein 44
Monoclonal Antibody for Mouse ER protein 44
Monoclonal Antibody for Mouse ER protein 44
Monoclonal Antibody for Mouse ER protein 44
Protein for Mouse ER protein 44
Protein for Mouse ER protein 44
Protein for Mouse ER protein 44
R&D Technical Data
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Precision
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Recovery
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Linearity
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Bone marrow .
tissue :
Embryo .
2.
"Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
Okazaki N.
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Kikuno R.
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Ohara R.
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Inamoto S.
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Koseki H.
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Hiraoka S.
,
Saga Y.
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Ohara O.
,
Koga H.
DNA Res.11:205-218(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Fetal brain .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Salivary gland .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH ITPR1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;MUTAGENESIS OF CYS-58