Errfi1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comErrfi1 ELISA Kit for Rat(Rattus norvegicus)

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Errfi1 (Gene name),

ERBB receptor feedback inhibitor 1 (Protein name ), ERRFI_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Errfi1(33;Mig6);

Protein name:

ERBB receptor feedback inhibitor 1;

Alternative:

Mitogen-inducible gene 6 protein homolog(MIG-6);Gene 33 polypeptide;Receptor-associated late transducer(RALT);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts with EGFR and ERBB2.

Function:

Negative regulator of EGFR signaling in skin morphogenesis. Acts as a negative regulator for several EGFR family members, including ERBB2, ERBB3 and ERBB4. Inhibits EGFR catalytic activity by interfering with its dimerization. Inhibits autophosphorylation of EGFR, ERBB2 and ERBB4. Important for normal keratinocyte proliferation and differentiation. Plays a role in modulating the response to steroid hormones in the uterus. Required for normal response to progesterone in the uterus and for fertility. Mediates epithelial estrogen responses in the uterus by regulating ESR1 levels and activation. Important for regulation of endometrium cell proliferation. Important for normal prenatal and perinatal lung development.

Subcellular Location:

Cytoplasm Cell membrane Peripheral membrane protein Cytoplasmic side Nucleus Associated with the plasma membrane of basal skin keratinocytes. Translocates into the nucleus of differentiating suprabasal keratinocytes.

Protein Attributes:

Sequence length:

459

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

459:

KHLSYVVSP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF09027

SMR:

P05432

KEGG:

rno:313729

UniGene:

Rn.100336

String:

P05432

STRING:

10116.ENSRNOP00000024606

Uniprot:

P05432

FOR

ELISA Kit for Rat ERBB receptor feedback inhibitor 1

CLIA Kit for Rat ERBB receptor feedback inhibitor 1

Polyclonal Antibody for Rat ERBB receptor feedback inhibitor 1

Monoclonal Antibody for Rat ERBB receptor feedback inhibitor 1

Protein for Rat ERBB receptor feedback inhibitor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Structure of a multihormonally regulated rat gene."
Tindal M.H. , Lee K.-L. , Isham K.R. , Cadilla C. , Kenney F.T.
Gene71:413-420(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: Sprague-Dawley.
tissue: Liver.
2.

"Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity."
Chrapkiewicz N.B. , Davis C.M. , Chu D.T.W. , Granner D.K.
Nucleic Acids Res.17:6651-6667(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
strain: Sprague-Dawley.
3.

"Molecular cloning and analysis of full-length cDNAs cognate to a rat gene under multihormonal control."
Lee K.-L. , Makkinje A. , Ch'Ang L.-Y. , Kenney F.T.
Arch. Biochem. Biophys.269:106-113(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
tissue: Liver.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
5.

"Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain."
Fiorentino L. , Pertica C. , Fiorini M. , Talora C. , Crescenzi M. , Castellani L. , Alema S. , Benedetti P. , Segatto O.
Mol. Cell. Biol.20:7735-7750(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION;INTERACTION WITH ERBB2
6.

"The evolutionarily conserved EBR module of RALT/MIG6 mediates suppression of the EGFR catalytic activity."
Anastasi S. , Baietti M.F. , Frosi Y. , Alema S. , Segatto O.
Oncogene26:7833-7846(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH EGFR

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