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Index > Protein center > EPS8L1(Gene name) > Human
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  • EPS8L1 (Gene name),
  • Epidermal growth factor receptor kinase substrate 8-like protein 1 (Protein name ),  ES8L1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EPS8L1(PP10566;DRC3;EPS8R1);
    Protein name:
    Epidermal growth factor receptor kinase substrate 8-like protein 1(EPS8-like protein 1);
    Alternative:
    Epidermal growth factor receptor pathway substrate 8-related protein 1(EPS8-related protein 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with ABI1. Part of a complex that contains SOS1, ABI1 and EPS8L2. Associates with F-actin.
    Function:
    Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    723
    Sequence:
    50:
    MSTATGPEAA | PKPSAKSIYE | QRKRYSTVVM | ADVSQYPVNH | LVTFCLGEDD | 
    100:
    GVHTVEDASR | KLAVMDSQGR | VWAQEMLLRV | SPDHVTLLDP | ASKEELESYP | 
    150:
    LGAIVRCDAV | MPPGRSRSLL | LLVCQEPERA | QPDVHFFQGL | RLGAELIRED | 
    200:
    IQGALHNYRS | GRGERRAAAL | RATQEELQRD | RSPAAETPPL | QRRPSVRAVI | 
    250:
    STVERGAGRG | RPQAKPIPEA | EEAQRPEPVG | TSSNADSASP | DLGPRGPDLA | 
    300:
    VLQAEREVDI | LNHVFDDVES | FVSRLQKSAE | AARVLEHRER | GRRSRRRAAG | 
    350:
    EGLLTLRAKP | PSEAEYTDVL | QKIKYAFSLL | ARLRGNIADP | SSPELLHFLF | 
    400:
    GPLQMIVNTS | GGPEFASSVR | RPHLTSDAVA | LLRDNVTPRE | NELWTSLGDS | 
    450:
    WTRPGLELSP | EEGPPYRPEF | FSGWEPPVTD | PQSRAWEDPV | EKQLQHERRR | 
    500:
    RQQSAPQVAV | NGHRDLEPES | EPQLESETAG | KWVLCNYDFQ | ARNSSELSVK | 
    550:
    QRDVLEVLDD | SRKWWKVRDP | AGQEGYVPYN | ILTPYPGPRL | HHSQSPARSL | 
    600:
    NSTPPPPPAP | APAPPPALAR | PRWDRPRWDS | CDSLNGLDPS | EKEKFSQMLI | 
    650:
    VNEELQARLA | QGRSGPSRAV | PGPRAPEPQL | SPGSDASEVR | AWLQAKGFSS | 
    700:
    GTVDALGVLT | GAQLFSLQKE | ELRAVSPEEG | ARVYSQVTVQ | RSLLEDKEKV | 
    723:
    SELEAVMEKQ | KKKVEGEVEM | EVI
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    Pfam:
    MIM:
    SMR:
    String:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human EPS8-like protein 1
    ELISA Kit for Human EPS8-like protein 1
    CLIA Kit for Human EPS8-like protein 1
    CLIA Kit for Human EPS8-like protein 1
    Polyclonal Antibody for Human EPS8-like protein 1
    Polyclonal Antibody for Human EPS8-like protein 1
    Monoclonal Antibody for Human EPS8-like protein 1
    Monoclonal Antibody for Human EPS8-like protein 1
    Protein for Human EPS8-like protein 1
    Protein for Human EPS8-like protein 1

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and expression analyses of down-regulated cDNA C6-2A in human esophageal cancer."
      Wu K. , Xu Z. , Wang M. , Xu X. , Han Y. , Cao Y. , Wang R. , Sun Y. , Wu M.
      Zhonghua Yi Xue Yi Chuan Xue Za Zhi16:325-327(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 4)
    2. 2.
      "In silico analysis of the EPS8 gene family: genomic organization, expression profile, and protein structure."
      Tocchetti A. , Confalonieri S. , Scita G. , Di Fiore P.P. , Betsholtz C.
      Genomics81:234-244(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS THR-4; GLU-457 AND ARG-669
    3. 3.
      "Large-scale cDNA transfection screening for genes related to cancer development and progression."
      Wan D. , Gong Y. , Qin W. , Zhang P. , Li J. , Wei L. , Zhou X. , Li H. , Qiu X. , Zhong F. , He L. , Yu J. , Yao G. , Jiang H. , Qian L. , Yu Y. , Shu H. , Chen X. , more...
      Proc. Natl. Acad. Sci. U.S.A.101:15724-15729(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS THR-4; GLU-457 AND ARG-669
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2);VARIANT ARG-669
      tissue: Placenta.
    5. 5.
      "The DNA sequence and biology of human chromosome 19."
      Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
      Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2 AND 3)
      tissue: Muscle.
      tissue: Skin.
    7. 7.
      "The eps8 family of proteins links growth factor stimulation to actin reorganization generating functional redundancy in the Ras/Rac pathway."
      Offenhaeuser N. , Borgonovo A. , Disanza A. , Romano P. , Ponzanelli I. , Iannolo G. , Di Fiore P.P. , Scita G.
      Mol. Biol. Cell15:91-98(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN A COMPLEX WITH ABI1 AND SOS1;INTERACTION WITH ABI1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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