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Index > Protein center > ESCO1(Gene name) > Human
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  • ESCO1 (Gene name),
  • N-acetyltransferase ESCO1 (Protein name ),  ESCO1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ESCO1(EFO1;KIAA1911);
    Protein name:
    N-acetyltransferase ESCO1;
    Alternative:
    Establishment factor-like protein 1(EFO1p;hEFO1);CTF7 homolog 1;Establishment of cohesion 1 homolog 1(ECO1 homolog 1;ESO1 homolog 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by mediating the acetylation of cohesin component SMC3.
    Subcellular Location:
    Nucleus Chromosome Nuclear at interphase, associated with chromosomes during mitosis.
    Protein Attributes:
    Sequence length:
    840
    Sequence:
    50:
    MMSIQEKSKE | NSSKVTKKSD | DKNSETEIQD | SQKNLAKKSG | PKETIKSQAK | 
    100:
    SSSESKINQP | ELETRMSTRS | SKAASNDKAT | KSINKNTVTV | RGYSQESTKK | 
    150:
    KLSQKKLVHE | NPKANEQLNR | RSQRLQQLTE | VSRRSLRSRE | IQGQVQAVKQ | 
    200:
    SLPPTKKEQC | SSTQSKSNKT | SQKHVKRKVL | EVKSDSKEDE | NLVINEVINS | 
    250:
    PKGKKRKVEH | QTACACSSQC | TQGSEKCPQK | TTRRDETKPV | PVTSEVKRSK | 
    300:
    MATSVVPKKN | EMKKSVHTQV | NTNTTLPKSP | QPSVPEQSDN | ELEQAGKSKR | 
    350:
    GSILQLCEEI | AGEIESDNVE | VKKESSQMES | VKEEKPTEIK | LEETSVERQI | 
    400:
    LHQKETNQDV | QCNRFFPSRK | TKPVKCILNG | INSSAKKNSN | WTKIKLSKFN | 
    450:
    SVQHNKLDSQ | VSPKLGLLRT | SFSPPALEMH | HPVTQSTFLG | TKLHDRNITC | 
    500:
    QQEKMKEINS | EEVKINDITV | EINKTTERAP | ENCHLANEIK | PSDPPLDNQM | 
    550:
    KHSFDSASNK | NFSQCLESKL | ENSPVENVTA | ASTLLSQAKI | DTGENKFPGS | 
    600:
    APQQHSILSN | QTSKSSDNRE | TPRNHSLPKC | NSHLEITIPK | DLKLKEAEKT | 
    650:
    DEKQLIIDAG | QKRFGAVSCN | VCGMLYTASN | PEDETQHLLF | HNQFISAVKY | 
    700:
    VGWKKERILA | EYPDGRIIMV | LPEDPKYALK | KVDEIREMVD | NDLGFQQAPL | 
    750:
    MCYSRTKTLL | FISNDKKVVG | CLIAEHIQWG | YRVIEEKLPV | IRSEEEKVRF | 
    800:
    ERQKAWCCST | LPEPAICGIS | RIWVFSMMRR | KKIASRMIEC | LRSNFIYGSY | 
    840:
    LSKEEIAFSD | PTPDGKLFAT | QYCGTGQFLV | YNFINGQNST | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    UniGene:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human N-acetyltransferase ESCO1
    ELISA Kit for Human N-acetyltransferase ESCO1
    CLIA Kit for Human N-acetyltransferase ESCO1
    CLIA Kit for Human N-acetyltransferase ESCO1
    Polyclonal Antibody for Human N-acetyltransferase ESCO1
    Polyclonal Antibody for Human N-acetyltransferase ESCO1
    Monoclonal Antibody for Human N-acetyltransferase ESCO1
    Monoclonal Antibody for Human N-acetyltransferase ESCO1
    Protein for Human N-acetyltransferase ESCO1
    Protein for Human N-acetyltransferase ESCO1

    R&D Technical Data
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    Precision
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Prediction of the coding sequences of unidentified human genes. XXI. The complete sequences of 60 new cDNA clones from brain which code for large proteins."
      Nagase T. , Kikuno R. , Ohara O.
      DNA Res.8:179-187(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Brain.
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Bone marrow.
      tissue: Melanoma.
    3. 3.
      NHLBI resequencing and genotyping service (RS&G)
      Submitted (2007-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 624-840 (ISOFORM 2);VARIANT MET-221
      tissue: Lymph.
      tissue: Mammary gland.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 437-840 (ISOFORM 1)
    7. 7.
      "Human EFO1p exhibits acetyltransferase activity and is a unique combination of linker histone and Ctf7p/Eco1p chromatid cohesion establishment domains."
      Bellows A.M. , Kenna M.A. , Cassimeris L. , Skibbens R.V.
      Nucleic Acids Res.31:6334-6343(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 1);FUNCTION;ENZYME ACTIVITY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    8. 8.
      "Two human orthologues of Eco1/Ctf7 acetyltransferases are both required for proper sister-chromatid cohesion."
      Hou F. , Zou H.
      Mol. Biol. Cell16:3908-3918(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ASSOCIATION WITH CHROMOSOMES;SUBCELLULAR LOCATION;PHOSPHORYLATION;MUTAGENESIS OF CYS-622
    9. 9.
      "Acetylation of Smc3 by Eco1 is required for S phase sister chromatid cohesion in both human and yeast."
      Zhang J. , Shi X. , Li Y. , Kim B.J. , Jia J. , Huang Z. , Yang T. , Fu X. , Jung S.Y. , Wang Y. , Zhang P. , Kim S.T. , Pan X. , Qin J.
      Mol. Cell31:143-151(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 11.
      "Cohesin acetylation speeds the replication fork."
      Terret M.E. , Sherwood R. , Rahman S. , Qin J. , Jallepalli P.V.
      Nature462:231-234(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION
    12. 12.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-200 AND SER-412;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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