Espn ELISA Kit for Mouse(Mus musculus) | EIAab.comEspn ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Espn(Gene name) > Mouse

Espn (Gene name),

Espin (Protein name ), ESPN_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Espn;

Protein name:

Espin;

Alternative:

Ectoplasmic specialization protein;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Binds F-actin in a Ca(2+)-resistant fashion. Interacts (via N-terminal) with BAIAP2 (via SH3-domain). Interacts with PFN2.

Function:

Multifunctional actin-bundling protein. Plays a major role in regulating the organization, dimensions, dynamics and signaling capacities of the actin filament-rich, microvillus-type specializations that mediate sensory transduction in variouS mechanosensory and chemosensory cells.

Subcellular Location:

Isoform 8 Cytoplasm cytoskeleton Cell junction Isoform 8 localizes to parallel actin bundles of ectoplasmic specializations between neighboring Sertoli cells and at sites where Sertoli cells contact the heads of elongate spermatids.

Protein Attributes:

Sequence length:

871

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

871:

DEAKLAPWQR | QVILKKGEIP | K

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9ET47

UniGene:

Mm.264215

String:

Q9ET47

Pfam:

PF00023

KEGG:

mmu:56226

Pfam:

PF12796

Uniprot:

Q9ET47

FOR

ELISA Kit for Mouse Espin

CLIA Kit for Mouse Espin

Polyclonal Antibody for Mouse Espin

Monoclonal Antibody for Mouse Espin

Protein for Mouse Espin

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"The deaf jerker mouse has a mutation in the gene encoding the espin actin-bundling proteins of hair cell stereocilia and lacks espins."
Zheng L. , Sekerkova G. , Vranich K. , Tilney L.G. , Mugnaini E. , Bartles J.R.
Cell102:377-385(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY
tissue: Testis.
2.

"Novel espin actin-bundling proteins are localized to Purkinje cell dendritic spines and bind the Src homology 3 adapter protein insulin receptor substrate p53."
Sekerkova G. , Loomis P.A. , Changyaleket B. , Zheng L. , Eytan R. , Chen B. , Mugnaini E. , Bartles J.R.
J. Neurosci.23:1310-1319(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3; 4 AND 5);TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH BAIAP2
strain: CBA/CaJ.
tissue: Cerebellum.
3.

"Espins are multifunctional actin cytoskeletal regulatory proteins in the microvilli of chemosensory and mechanosensory cells."
Sekerkova G. , Zheng L. , Loomis P.A. , Changyaleket B. , Whitlon D.S. , Mugnaini E. , Bartles J.R.
J. Neurosci.24:5445-5456(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 6 AND 7);FUNCTION;INTERACTION WITH PFN2;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: CD-1.
4.

"Espin contains an additional actin-binding site in its N terminus and is a major actin-bundling protein of the Sertoli cell-spermatid ectoplasmic specialization junctional plaque."
Chen B. , Li A. , Wang D. , Wang M. , Zheng L. , Bartles J.R.
Mol. Biol. Cell10:4327-4339(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 8);SUBUNIT
strain: 129/SvJ.
5.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
6.

"Espin cross-links cause the elongation of microvillus-type parallel actin bundles in vivo."
Loomis P.A. , Zheng L. , Sekerkova G. , Changyaleket B. , Mugnaini E. , Bartles J.R.
J. Cell Biol.163:1045-1055(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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