Esr2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comEsr2 ELISA Kit for Rat(Rattus norvegicus)

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Esr2 (Gene name),

Estrogen receptor beta (Protein name ), ESR2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Esr2(Erbeta;Nr3a2);

Protein name:

Estrogen receptor beta(ER-beta);

Alternative:

Nuclear receptor subfamily 3 group A member 2;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Binds DNA as a homodimer. Can form a heterodimer with ESR1. Interacts with NCOA3, NCOA5 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with PELP1, UBE1C and AKAP13. Interacts with DNTTIP2 (By similarity). Interacts with CCDC62 in the presence of estradiol/E2; this interaction seems to enhance the transcription of target genes (By similarity). Interacts with PRMT2 (By similarity). Interacts with DYX1C1.

Function:

Binds estrogens with an affinity similar to that of ER-alpha, and activates expression of reporter genes containing estrogen response elements (ERE) in an estrogen-dependent manner. Isoform 3 and isoform 4 are unable to bind DNA and activate transcription due to the truncation of the DNA binding domain. Isoform 2 shows loss of ligand binding affinity and suppresses ER-alpha and ER-beta1 mediated transcriptional activation and may act as a dominant negative regulator of estrogen action.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

530

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

530:

RGYKSSISGS | ECSSTEDSKN | KESSQNLQSQ |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q62986

Pfam:

PF12497

UniGene:

Rn.37460

KEGG:

rno:25149

SMR:

Q62986

Uniprot:

Q62986

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ELISA Kit for Rat ER-beta

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E2300h

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96T

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ELISA Kit for Rat ER-beta

Cat.:

E2300r

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96T

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ELISA Kit for Rat ER-beta

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E2300p

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ELISA Kit for Rat ER-beta

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E2300c

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ELISA Kit for Rat ER-beta

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E2300b

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ELISA Kit for Rat ER-beta

Cat.:

E2300m

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96T

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CLIA Kit for Rat ER-beta

Cat.:

U2300m

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96T

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CLIA Kit for Rat ER-beta

Cat.:

U2300h

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96T

CLIA Kit for Rat ER-beta

Cat.:

U2300p

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96T

CLIA Kit for Rat ER-beta

Cat.:

U2300b

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96T

CLIA Kit for Rat ER-beta

Cat.:

U2300r

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96T

CLIA Kit for Rat ER-beta

Cat.:

U2300c

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96T

Polyclonal Antibody for Rat ER-beta

Cat.:

P2300Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat ER-beta

Cat.:

P2300Rb-h

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40ug/0.2ml

Polyclonal Antibody for Rat ER-beta

Cat.:

P2300Rb-m

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40ug/0.2ml

Polyclonal Antibody for Rat ER-beta

Monoclonal Antibody for Rat ER-beta

Protein for Rat ER-beta

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Cloning of a novel receptor expressed in rat prostate and ovary."
Kuiper G.G.J.M. , Enmark E. , Pelto-Huikko M. , Nilsson S. , Gustafsson J.-A.
Proc. Natl. Acad. Sci. U.S.A.93:5925-5930(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-530 (ISOFORM 1)
strain: Sprague-Dawley.
tissue: Prostate.
2.

"A novel isoform of rat estrogen receptor beta with 18 amino acid insertion in the ligand binding domain as a putative dominant negative regular of estrogen action."
Maruyama K. , Endoh H. , Sasaki-Iwaoka H. , Kanou H. , Shimaya E. , Hashimoto S. , Kato S. , Kawashima H.
Biochem. Biophys. Res. Commun.246:142-147(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 46-530 (ISOFORM 2)
strain: Wistar.
tissue: Ovary.
3.

"Tissue specific responses to estrogen: an explanation based on differential activation of multiple estrogen receptors with different estrogen response elements."
Aldridge T.C.
Submitted (1997-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 2)
strain: Wistar.
tissue: Prostate.
4.

"Identification of estrogen receptor beta2, a functional variant of estrogen receptor beta expressed in normal rat tissues."
Petersen D.N. , Tkalcevic G.T. , Koza-Taylor P.H. , Turi T.G. , Brown T.A.
Endocrinology139:1082-1092(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 46-530 (ISOFORMS 1; 3 AND 4)
strain: Sprague-Dawley.
5.

"A novel splice variant of estrogen receptor beta found in rat brain."
Price R. , Handa R.J.
Submitted (1999-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE (ISOFORM 5)
strain: Sprague-Dawley.
tissue: Brain.
6.

"The activating enzyme of NEDD8 inhibits steroid receptor function."
Fan M. , Long X. , Bailey J.A. , Reed C.A. , Osborne E. , Gize E.A. , Kirk E.A. , Bigsby R.M. , Nephew K.P.
Mol. Endocrinol.16:315-330(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBE1C
7.

"Functional interaction of DYX1C1 with estrogen receptors suggests involvement of hormonal pathways in dyslexia."
Massinen S. , Tammimies K. , Tapia-Paez I. , Matsson H. , Hokkanen M.E. , Soederberg O. , Landegren U. , Castren E. , Gustafsson J.A. , Treuter E. , Kere J.
Hum. Mol. Genet.18:2802-2812(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DYX1C1

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