SMG6 ELISA Kit for Human(Homo sapiens) | EIAab.comSMG6 ELISA Kit for Human(Homo sapiens) | EIAab.com

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SMG6 (Gene name),

Telomerase-binding protein EST1A (Protein name ), EST1A_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Gene name:

SMG6(C17orf31;EST1A;KIAA0732);

Protein name:

Telomerase-binding protein EST1A;

Alternative:

Ever shorter telomeres 1A;EST1-like protein A;Telomerase subunit EST1A;Smg-6 homolog;hSmg5/7a;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Component of the telomerase holoenzyme complex at least composed of TERT, DKC1, WRAP53/TCAB1, NOP10, NHP2, GAR1, TEP1, EST1A, POT1 and a telomerase RNA template component (TERC). Interacts with TERT, independently of the telomerase RNA. Interacts with PP2A catalytic subunits, SMG1, UPF1, UPF2 and UPF3B.

Function:

Plays a role in nonsense-mediated mRNA decay. Is thought to provide a link to the mRNA degradation machinery as it has endonuclease activity required to initiate NMD, and to serve as an adapter for UPF1 to protein phosphatase 2A (PP2A), thereby triggering UPF1 dephosphorylation. Degrades single-stranded RNA (ssRNA), but not ssDNA or dsRNA.

Subcellular Location:

Nucleus nucleolus Chromosome telomere Cytoplasm cytosol Particularly enriched in the nucleolus.

Protein Attributes:

Sequence length:

1419

Sequence:

50:

MAEGLERVRI | SASELRGILA | TLAPQAGSRE | NMKELKEARP | RKDNRRPDLE |

100:

IYKPGLSRLR | NKPKIKEPPG | SEEFKDEIVN | DRDCSAVENG | TQPVKDVCKE |

150:

LNNQEQNGPI | DPENNRGQES | FPRTAGQEDR | SLKIIKRTKK | PDLQIYQPGR |

200:

RLQTVSKESA | SRVEEEEVLN | QVEQLRVEED | ECRGNVAKEE | VANKPDRAEI |

250:

EKSPGGGRVG | AAKGEKGKRM | GKGEGVRETH | DDPARGRPGS | AKRYSRSDKR |

300:

RNRYRTRSTS | SAGSNNSAEG | AGLTDNGCRR | RRQDRTKERP | RLKKQVSVSS |

350:

TDSLDEDRID | EPDGLGPRRS | SERKRHLERN | WSGRGEGEQK | NSAKEYRGTL |

400:

RVTFDAEAMN | KESPMVRSAR | DDMDRGKPDK | GLSSGGKGSE | KQESKNPKQE |

450:

LRGRGRGILI | LPAHTTLSVN | SAGSPESAPL | GPRLLFGSGS | KGSRSWGRGG |

500:

TTRRLWDPNN | PDQKPALKTQ | TPQLHFLDTD | DEVSPTSWGD | SRQAQASYYK |

550:

FQNSDNPYYY | PRTPGPASQY | PYTGYNPLQY | PVGPTNGVYP | GPYYPGYPTP |

600:

SGQYVCSPLP | TSTMSPEEVE | QHMRNLQQQE | LHRLLRVADN | QELQLSNLLS |

650:

RDRISPEGLE | KMAQLRAELL | QLYERCILLD | IEFSDNQNVD | QILWKNAFYQ |

700:

VIEKFRQLVK | DPNVENPEQI | RNRLLELLDE | GSDFFDSLLQ | KLQVTYKFKL |

750:

EDYMDGLAIR | SKPLRKTVKY | ALISAQRCMI | CQGDIARYRE | QASDTANYGK |

800:

ARSWYLKAQH | IAPKNGRPYN | QLALLAVYTR | RKLDAVYYYM | RSLAASNPIL |

850:

TAKESLMSLF | EETKRKAEQM | EKKQHEEFDL | SPDQWRKGKK | STFRHVGDDT |

900:

TRLEIWIHPS | HPRSSQGTES | GKDSEQENGL | GSLSPSDLNK | RFILSFLHAH |

950:

GKLFTRIGME | TFPAVAEKVL | KEFQVLLQHS | PSPIGSTRML | QLMTINMFAV |

1000:

HNSQLKDCFS | EECRSVIQEQ | AAALGLAMFS | LLVRRCTCLL | KESAKAQLSS |

1050:

PEDQDDQDDI | KVSSFVPDLK | ELLPSVKVWS | DWMLGYPDTW | NPPPTSLDLP |

1100:

SHVAVDVWST | LADFCNILTA | VNQSEVPLYK | DPDDDLTLLI | LEEDRLLSGF |

1150:

VPLLAAPQDP | CYVEKTSDKV | IAADCKRVTV | LKYFLEALCG | QEEPLLAFKG |

1200:

GKYVSVAPVP | DTMGKEMGSQ | EGTRLEDEEE | DVVIEDFEED | SEAEGSGGED |

1250:

DIRELRAKKL | ALARKIAEQQ | RRQEKIQAVL | EDHSQMRQME | LEIRPLFLVP |

1300:

DTNGFIDHLA | SLARLLESRK | YILVVPLIVI | NELDGLAKGQ | ETDHRAGGYA |

1350:

RVVQEKARKS | IEFLEQRFES | RDSCLRALTS | RGNELESIAF | RSEDITGQLG |

1400:

NNDDLILSCC | LHYCKDKAKD | FMPASKEEPI | RLLREVVLLT | DDRNLRVKAL |

1419:

TRNVPVRDIP | AFLTWAQVG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

MIM:

STRING:

9606.ENSP00000263073

SMR:

Pfam:

UniGene:

KEGG:

Uniprot:

FOR

ELISA Kit for Human Telomerase-binding protein EST1A

ELISA Kit for Human Telomerase-binding protein EST1A

CLIA Kit for Human Telomerase-binding protein EST1A

CLIA Kit for Human Telomerase-binding protein EST1A

Polyclonal Antibody for Human Telomerase-binding protein EST1A

Polyclonal Antibody for Human Telomerase-binding protein EST1A

Monoclonal Antibody for Human Telomerase-binding protein EST1A

Monoclonal Antibody for Human Telomerase-binding protein EST1A

Protein for Human Telomerase-binding protein EST1A

Protein for Human Telomerase-binding protein EST1A

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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Recovery

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Linearity

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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References

1.

"A human homolog of yeast est1 associates with telomerase and uncaps chromosome ends when overexpressed."
Reichenbach P. , Hoess M. , Azzalin C.M. , Nabholz M. , Bucher P. , Lingner J.
Curr. Biol.13:568-574(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT THR-341;FUNCTION IN TELOMERE REGULATION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX
tissue: Cervix carcinoma.
2.

"Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS PRO-291 AND THR-341
tissue: Brain.
3.

"Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones."
Nakajima D. , Okazaki N. , Yamakawa H. , Kikuno R. , Ohara O. , Nagase T.
DNA Res.9:99-106(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION
4.

"The full-ORF clone resource of the German cDNA consortium."
Bechtel S. , Rosenfelder H. , Duda A. , Schmidt C.P. , Ernst U. , Wellenreuther R. , Mehrle A. , Schuster C. , Bahr A. , Bloecker H. , Heubner D. , Hoerlein A. , Michel G. , Wedler H. , Koehrer K. , Ottenwaelder B. , Poustka A. , Wiemann S. , more...
BMC Genomics8:399-399(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Testis.
5.

"Functional conservation of the telomerase protein Est1p in humans."
Snow B.E. , Erdmann N. , Cruickshank J. , Goldman H. , Gill R.M. , Robinson M.O. , Harrington L.
Curr. Biol.13:698-704(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 32-1419 (ISOFORM 1);FUNCTION IN TELOMERE REGULATION;TISSUE SPECIFICITY;SINGLE-STRANDED TELOMERE DNA-BINDING;IDENTIFICATION IN THE TELOMERASE RIBONUCLEOPROTEIN COMPLEX;INTERACTION WITH TERT
6.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Testis.
7.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 888-1419 (ISOFORM 1)
tissue: Testis.
10.

"Characterization of human Smg5/7a: a protein with similarities to Caenorhabditis elegans SMG5 and SMG7 that functions in the dephosphorylation of Upf1."
Chiu S.-Y. , Serin G. , Ohara O. , Maquat L.E.
RNA9:77-87(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PP2A CATALYTIC SUBUNITS; SMG1; UPF1; UPF2 AND UPF3B
11.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
12.

"SMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoan."
Huntzinger E. , Kashima I. , Fauser M. , Sauliere J. , Izaurralde E.
RNA14:2609-2617(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NONSENSE-MEDIATED MRNA DECAY;CATALYTIC ACTIVITY;DOMAIN;MUTAGENESIS OF ASP-1251 AND ASP-1392
13.

"SMG6 promotes endonucleolytic cleavage of nonsense mRNA in human cells."
Eberle A.B. , Lykke-Andersen S. , Muhlemann O. , Jensen T.H.
Nat. Struct. Mol. Biol.16:49-55(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NONSENSE-MEDIATED MRNA DECAY;CATALYTIC ACTIVITY;DOMAIN;SUBCELLULAR LOCATION;INTERACTION WITH UPF1;MUTAGENESIS OF ASP-1251; ASP-1353 AND ASP-1392
14.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-479;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
15.

"A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis."
Venteicher A.S. , Abreu E.B. , Meng Z. , McCann K.E. , Terns R.M. , Veenstra T.D. , Terns M.P. , Artandi S.E.
Science323:644-648(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE TELOMERASE HOLOENZYME COMPLEX
16.

"SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decay."
Kashima I. , Jonas S. , Jayachandran U. , Buchwald G. , Conti E. , Lupas A.N. , Izaurralde E.
Genes Dev.24:2440-2450(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN NONSENSE-MEDIATED MRNA DECAY;HOMOOLIGOMERIZATION;INTERACTION WITH UPF1; UPF2; UPF3B; SMG5; SMG7 AND THE EXON JUNCTION COMPLEX;MUTAGENESIS OF 46-ARG--TYR-52 AND 140-LYS--TYR-146
17.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
18.

"Structures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complex."
Glavan F. , Behm-Ansmant I. , Izaurralde E. , Conti E.
EMBO J.25:5117-5125(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 1239-1419;FUNCTION;COFACTOR;CATALYTIC ACTIVITY;MUTAGENESIS OF ASP-1353
19.

"Crystal structure of the PIN domain of human telomerase-associated protein EST1A."
Takeshita D. , Zenno S. , Lee W.C. , Saigo K. , Tanokura M.
Proteins68:980-989(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS) OF 1239-1419

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