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Index > Protein center > ESYT1(Gene name) > Human
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  • ESYT1 (Gene name),
  • Extended synaptotagmin-1 (Protein name ),  ESYT1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    ESYT1(FAM62A;KIAA0747;MBC2);
    Protein name:
    Extended synaptotagmin-1(E-Syt1);
    Alternative:
    Membrane-bound C2 domain-containing protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May play a role as calcium-regulated intrinsic membrane protein.
    Subcellular Location:
    Membrane Multi-pass membrane protein Localizes to intracellular membranes.
    Protein Attributes:
    Sequence length:
    1104
    Sequence:
    50:
    MERSPGEGPS | PSPMDQPSAP | SDPTDQPPAA | HAKPDPGSGG | QPAGPGAAGE | 
    100:
    ALAVLTSFGR | RLLVLIPVYL | AGAVGLSVGF | VLFGLALYLG | WRRVRDEKER | 
    150:
    SLRAARQLLD | DEEQLTAKTL | YMSHRELPAW | VSFPDVEKAE | WLNKIVAQVW | 
    200:
    PFLGQYMEKL | LAETVAPAVR | GSNPHLQTFT | FTRVELGEKP | LRIIGVKVHP | 
    250:
    GQRKEQILLD | LNISYVGDVQ | IDVEVKKYFC | KAGVKGMQLH | GVLRVILEPL | 
    300:
    IGDLPFVGAV | SMFFIRRPTL | DINWTGMTNL | LDIPGLSSLS | DTMIMDSIAA | 
    350:
    FLVLPNRLLV | PLVPDLQDVA | QLRSPLPRGI | IRIHLLAARG | LSSKDKYVKG | 
    400:
    LIEGKSDPYA | LVRLGTQTFC | SRVIDEELNP | QWGETYEVMV | HEVPGQEIEV | 
    450:
    EVFDKDPDKD | DFLGRMKLDV | GKVLQASVLD | DWFPLQGGQG | QVHLRLEWLS | 
    500:
    LLSDAEKLEQ | VLQWNWGVSS | RPDPPSAAIL | VVYLDRAQDL | PLKKGNKEPN | 
    550:
    PMVQLSIQDV | TQESKAVYST | NCPVWEEAFR | FFLQDPQSQE | LDVQVKDDSR | 
    600:
    ALTLGALTLP | LARLLTAPEL | ILDQWFQLSS | SGPNSRLYMK | LVMRILYLDS | 
    650:
    SEICFPTVPG | CPGAWDVDSE | NPQRGSSVDA | PPRPCHTTPD | SQFGTEHVLR | 
    700:
    IHVLEAQDLI | AKDRFLGGLV | KGKSDPYVKL | KLAGRSFRSH | VVREDLNPRW | 
    750:
    NEVFEVIVTS | VPGQELEVEV | FDKDLDKDDF | LGRCKVRLTT | VLNSGFLDEW | 
    800:
    LTLEDVPSGR | LHLRLERLTP | RPTAAELEEV | LQVNSLIQTQ | KSAELAAALL | 
    850:
    SIYMERAEDL | PLRKGTKHLS | PYATLTVGDS | SHKTKTISQT | SAPVWDESAS | 
    900:
    FLIRKPHTES | LELQVRGEGT | GVLGSLSLPL | SELLVADQLC | LDRWFTLSSG | 
    950:
    QGQVLLRAQL | GILVSQHSGV | EAHSHSYSHS | SSSLSEEPEL | SGGPPHITSS | 
    1000:
    APELRQRLTH | VDSPLEAPAG | PLGQVKLTLW | YYSEERKLVS | IVHGCRSLRQ | 
    1050:
    NGRDPPDPYV | SLLLLPDKNR | GTKRRTSQKK | RTLSPEFNER | FEWELPLDEA | 
    1100:
    QRRKLDVSVK | SNSSFMSRER | ELLGKVQLDL | AETDLSQGVA | RWYDLMDNKD | 
    1104:
    KGSS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    KEGG:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human E-Syt1
    ELISA Kit for Human E-Syt1
    ELISA Kit for Human E-Syt1
    CLIA Kit for Human E-Syt1
    CLIA Kit for Human E-Syt1
    CLIA Kit for Human E-Syt1
    Polyclonal Antibody for Human E-Syt1
    Polyclonal Antibody for Human E-Syt1
    Polyclonal Antibody for Human E-Syt1
    Monoclonal Antibody for Human E-Syt1
    Monoclonal Antibody for Human E-Syt1
    Monoclonal Antibody for Human E-Syt1
    Protein for Human E-Syt1
    Protein for Human E-Syt1
    Protein for Human E-Syt1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    References
    1. 1.
      "E-Syts, a family of membranous Ca2+-sensor proteins with multiple C2 domains."
      Min S.-W. , Chang W.-P. , Suedhof T.C.
      Proc. Natl. Acad. Sci. U.S.A.104:3823-3828(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    2. 2.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Hepatoma.
      tissue: Kidney.
      tissue: Tongue.
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Kidney.
    5. 5.
      "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Ishikawa K. , Suyama M. , Kikuno R. , Miyajima N. , Tanaka A. , Kotani H. , Nomura N. , Ohara O.
      DNA Res.5:277-286(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 43-1104 (ISOFORM 2)
      tissue: Brain.
    6. 6.
      Bienvenut W.V. , Claeys D.
      Submitted (2005-11) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 308-323; 446-457 AND 551-586;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
      tissue: Platelet.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 379-1104 (ISOFORM 1)
      tissue: Uterus.
    8. 8.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-963 AND SER-1034;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-817;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-820 AND SER-963;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "PI(4,5)P(2)-dependent and Ca(2+)-regulated ER-PM interactions mediated by the extended synaptotagmins."
      Giordano F. , Saheki Y. , Idevall-Hagren O. , Colombo S.F. , Pirruccello M. , Milosevic I. , Gracheva E.O. , Bagriantsev S.N. , Borgese N. , De Camilli P.
      Cell153:1494-1509(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;TOPOLOGY;LIPID-BINDING;MUTAGENESIS OF ASP-663; ASP-675 AND 722-ASP--ASP-729;INTERACTION WITH ESYT2 AND ESYT3
    16. 16.
      "Feedback regulation of receptor-induced Ca2+ signaling mediated by E-Syt1 and Nir2 at endoplasmic reticulum-plasma membrane junctions."
      Chang C.L. , Hsieh T.S. , Yang T.T. , Rothberg K.G. , Azizoglu D.B. , Volk E. , Liao J.C. , Liou J.
      Cell Rep.5:813-825(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-406 AND ASP-724
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