Protein name:
MDS1 and EVI1 complex locus protein EVI1 ;
Alternative:
Ecotropic virus integration site 1 protein homolog (EVI-1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and MAPK9; inhibits JNK signaling.
Function:
Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
Subcellular Location:
Nucleus
Nucleus speckle
Protein Attributes:
50:
MKSEDYPHET | MAPDIHEERQ | YRCEDCDQLF | ESKAELADHQ | KFPCSTPHSA |
100:
FSMVEEDFQQ | KLESENDLQE | IHTIQECKEC | DQVFPDLQSL | EKHMLSHTEE |
150:
REYKCDQCPK | AFNWKSNLIR | HQMSHDSGKH | YECENCAKVF | TDPSNLQRHI |
200:
RSQHVGARAH | ACPECGKTFA | TSSGLKQHKH | IHSSVKPFIC | EVCHKSYTQF |
250:
SNLCRHKRMH | ADCRTQIKCK | DCGQMFSTTS | SLNKHRRFCE | GKNHFAAGGF |
300:
FGQGISLPGT | PAMDKTSMVN | MSHANPGLAD | YFGANRHPAG | LTFPTAPGFS |
350:
FSFPGLFPSG | LYHRPPLIPA | SSPVKGLSST | EQTNKSQSPL | MTHPQILPAT |
400:
QDILKALSKH | PSVGDNKPVE | LQPERSSEER | PFEKISDQSE | SSDLDDVSTP |
450:
SGSDLETTSG | SDLESDIESD | KEKFKENGKM | FKDKVSPLQN | LASINNKKEY |
500:
SNHSIFSPSL | EEQTAVSGAV | NDSIKAIASI | AEKYFGSTGL | VGLQDKKVGA |
550:
LPYPSMFPLP | FFPAFSQSMY | PFPDRDLRSL | PLKMEPQSPG | EVKKLQKGSS |
600:
ESPFDLTTKR | KDEKPLTPVP | SKPPVTPATS | QDQPLDLSMG | SRSRASGTKL |
650:
TEPRKNHVFG | GKKGSNVESR | PASDGSLQHA | RPTPFFMDPI | YRVEKRKLTD |
700:
PLEALKEKYL | RPSPGFLFHP | QFQLPDQRTW | MSAIENMAEK | LESFSALKPE |
750:
ASELLQSVPS | MFNFRAPPNA | LPENLLRKGK | ERYTCRYCGK | IFPRSANLTR |
800:
HLRTHTGEQP | YRCKYCDRSF | SISSNLQRHV | RNIHNKEKPF | KCHLCDRCFG |
850:
QQTNLDRHLK | KHENGNMSGT | ATSSPHSELE | STGAILDDKE | DAYFTEIRNF |
900:
IGNSNHGSQS | PRNVEERMNG | SHFKDEKALV | TSQNSDLLDD | EEVEDEVLLD |
950:
EEDEDNDITG | KTGKEPVTSN | LHEGNPEDDY | EETSALEMSC | KTSPVRYKEE |
1000:
EYKSGLSALD | HIRHFTDSLK | MRKMEDNQYS | EAELSSFSTS | HVPEELKQPL |
1050:
HRKSKSQAYA | MMLSLSDKES | LHSTSHSSSN | VWHSMARAAA | ESSAIQSISH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Mouse
Human
Human
ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
Protein for Human MDS1 and EVI1 complex locus protein EVI1
Protein for Human MDS1 and EVI1 complex locus protein EVI1
Protein for Human MDS1 and EVI1 complex locus protein EVI1
Protein for Human MDS1 and EVI1 complex locus protein EVI1
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-759 (ISOFORM 2)
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Trachea .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
tissue :
Adipose tissue .
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Fetal kidney .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6);NUCLEOTIDE SEQUENCE [MRNA] OF 516-1051 (ISOFORM 5)
tissue :
Lung .
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Oncogene13:183-191(1996)
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PubMed ]
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 970-1007 (ISOFORM 1)
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION IN TGF-BETA SIGNALING;INTERACTION WITH SMAD3 AND SMAD4;SUBCELLULAR LOCATION
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MAPK8 AND MAPK9
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ACETYLATION;INTERACTION WITH CREBBP; CTBP1; KAT2B AND HISTONE DEACETYLASES;SUBCELLULAR LOCATION;MUTAGENESIS OF 555-ASP-LEU-556 AND 586-ASP-LEU-587
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);HOMOOLIGOMERIZATION;INTERACTION WITH CTBP1 AND SMAD3;SUBCELLULAR LOCATION
13.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
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Cited for : FUNCTION IN APOPTOSIS
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
16.
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Cited for : FUNCTION
17.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-860;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .