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Index > Protein center > MECOM(Gene name) > Human
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  • MECOM (Gene name),
  • MDS1 and EVI1 complex locus protein EVI1 (Protein name ),  EVI1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    MECOM(EVI1);
    Protein name:
    MDS1 and EVI1 complex locus protein EVI1;
    Alternative:
    Ecotropic virus integration site 1 protein homolog(EVI-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homooligomer. Interacts with SUV39H1 (via SET domain); enhances MECOM transcriptional repression activity (By similarity). Interacts with CTBP1. Interacts with SMAD3 (via MH2 domain); the interaction is direct. Interacts with SMAD4; through interaction with SMAD3. Interacts with CREBBP, KAT2B and histone deacetylases. Interacts with MAPK8 and MAPK9; inhibits JNK signaling.
    Function:
    Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis.
    Subcellular Location:
    Nucleus Nucleus speckle
    Protein Attributes:
    Sequence length:
    1051
    Sequence:
    50:
    MKSEDYPHET | MAPDIHEERQ | YRCEDCDQLF | ESKAELADHQ | KFPCSTPHSA | 
    100:
    FSMVEEDFQQ | KLESENDLQE | IHTIQECKEC | DQVFPDLQSL | EKHMLSHTEE | 
    150:
    REYKCDQCPK | AFNWKSNLIR | HQMSHDSGKH | YECENCAKVF | TDPSNLQRHI | 
    200:
    RSQHVGARAH | ACPECGKTFA | TSSGLKQHKH | IHSSVKPFIC | EVCHKSYTQF | 
    250:
    SNLCRHKRMH | ADCRTQIKCK | DCGQMFSTTS | SLNKHRRFCE | GKNHFAAGGF | 
    300:
    FGQGISLPGT | PAMDKTSMVN | MSHANPGLAD | YFGANRHPAG | LTFPTAPGFS | 
    350:
    FSFPGLFPSG | LYHRPPLIPA | SSPVKGLSST | EQTNKSQSPL | MTHPQILPAT | 
    400:
    QDILKALSKH | PSVGDNKPVE | LQPERSSEER | PFEKISDQSE | SSDLDDVSTP | 
    450:
    SGSDLETTSG | SDLESDIESD | KEKFKENGKM | FKDKVSPLQN | LASINNKKEY | 
    500:
    SNHSIFSPSL | EEQTAVSGAV | NDSIKAIASI | AEKYFGSTGL | VGLQDKKVGA | 
    550:
    LPYPSMFPLP | FFPAFSQSMY | PFPDRDLRSL | PLKMEPQSPG | EVKKLQKGSS | 
    600:
    ESPFDLTTKR | KDEKPLTPVP | SKPPVTPATS | QDQPLDLSMG | SRSRASGTKL | 
    650:
    TEPRKNHVFG | GKKGSNVESR | PASDGSLQHA | RPTPFFMDPI | YRVEKRKLTD | 
    700:
    PLEALKEKYL | RPSPGFLFHP | QFQLPDQRTW | MSAIENMAEK | LESFSALKPE | 
    750:
    ASELLQSVPS | MFNFRAPPNA | LPENLLRKGK | ERYTCRYCGK | IFPRSANLTR | 
    800:
    HLRTHTGEQP | YRCKYCDRSF | SISSNLQRHV | RNIHNKEKPF | KCHLCDRCFG | 
    850:
    QQTNLDRHLK | KHENGNMSGT | ATSSPHSELE | STGAILDDKE | DAYFTEIRNF | 
    900:
    IGNSNHGSQS | PRNVEERMNG | SHFKDEKALV | TSQNSDLLDD | EEVEDEVLLD | 
    950:
    EEDEDNDITG | KTGKEPVTSN | LHEGNPEDDY | EETSALEMSC | KTSPVRYKEE | 
    1000:
    EYKSGLSALD | HIRHFTDSLK | MRKMEDNQYS | EAELSSFSTS | HVPEELKQPL | 
    1050:
    HRKSKSQAYA | MMLSLSDKES | LHSTSHSSSN | VWHSMARAAA | ESSAIQSISH | 
    1051:
    V
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    MIM:
    String:
    KEGG:
    Pfam:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    ELISA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    CLIA Kit for Human MDS1 and EVI1 complex locus protein EVI1
    Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Polyclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Monoclonal Antibody for Human MDS1 and EVI1 complex locus protein EVI1
    Protein for Human MDS1 and EVI1 complex locus protein EVI1
    Protein for Human MDS1 and EVI1 complex locus protein EVI1
    Protein for Human MDS1 and EVI1 complex locus protein EVI1
    Protein for Human MDS1 and EVI1 complex locus protein EVI1

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    References
    1. 1.
      "Unique expression of the human Evi-1 gene in an endometrial carcinoma cell line: sequence of cDNAs and structure of alternatively spliced transcripts."
      Morishita K. , Parganas E. , Douglass E.C. , Ihle J.N.
      Oncogene5:963-971(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);ALTERNATIVE SPLICING
    2. 2.
      "Generation of the AML1-EVI-1 fusion gene in the t(3;21)(q26;q22) causes blastic crisis in chronic myelocytic leukemia."
      Mitani K. , Ogawa S. , Tanaka T. , Miyoshi H. , Kurokawa M. , Mano H. , Yazaki Y. , Ohki M. , Hirai H.
      EMBO J.13:504-510(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);CHROMOSOMAL TRANSLOCATION WITH RUNX1 IN CHRONIC MYELOCYTIC LEUKEMIA
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-759 (ISOFORM 2)
      tissue: Trachea.
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5)
      tissue: Adipose tissue.
      tissue: Fetal kidney.
    5. 5.
      "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M. , Scherer S.E. , Kaul R. , Wang J. , Yu J. , Sudbrak R. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , more...
      Nature440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 4 AND 6);NUCLEOTIDE SEQUENCE [MRNA] OF 516-1051 (ISOFORM 5)
      tissue: Lung.
    8. 8.
      "Structurally altered Evi-1 protein generated in the 3q21q26 syndrome."
      Ogawa S. , Kurokawa M. , Tanaka T. , Mitani K. , Inazawa J. , Hangaishi A. , Tanaka K. , Matsuo Y. , Minowada J. , Tsubota T. , Yazaki Y. , Hirai H.
      Oncogene13:183-191(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 970-1007 (ISOFORM 1)
    9. 9.
      "The oncoprotein Evi-1 represses TGF-beta signalling by inhibiting Smad3."
      Kurokawa M. , Mitani K. , Irie K. , Matsuyama T. , Takahashi T. , Chiba S. , Yazaki Y. , Matsumoto K. , Hirai H.
      Nature394:92-96(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN TGF-BETA SIGNALING;INTERACTION WITH SMAD3 AND SMAD4;SUBCELLULAR LOCATION
    10. 10.
      "The evi-1 oncoprotein inhibits c-Jun N-terminal kinase and prevents stress-induced cell death."
      Kurokawa M. , Mitani K. , Yamagata T. , Takahashi T. , Izutsu K. , Ogawa S. , Moriguchi T. , Nishida E. , Yazaki Y. , Hirai H.
      EMBO J.19:2958-2968(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAPK8 AND MAPK9
    11. 11.
      "Interaction of EVI1 with cAMP-responsive element-binding protein-binding protein (CBP) and p300/CBP-associated factor (P/CAF) results in reversible acetylation of EVI1 and in co-localization in nuclear speckles."
      Chakraborty S. , Senyuk V. , Sitailo S. , Chi Y. , Nucifora G.
      J. Biol. Chem.276:44936-44943(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ACETYLATION;INTERACTION WITH CREBBP; CTBP1; KAT2B AND HISTONE DEACETYLASES;SUBCELLULAR LOCATION;MUTAGENESIS OF 555-ASP-LEU-556 AND 586-ASP-LEU-587
    12. 12.
      "Oligomerization of Evi-1 regulated by the PR domain contributes to recruitment of corepressor CtBP."
      Nitta E. , Izutsu K. , Yamaguchi Y. , Imai Y. , Ogawa S. , Chiba S. , Kurokawa M. , Hirai H.
      Oncogene24:6165-6173(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;ALTERNATIVE SPLICING (ISOFORMS 1 AND 2);HOMOOLIGOMERIZATION;INTERACTION WITH CTBP1 AND SMAD3;SUBCELLULAR LOCATION
    13. 13.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    14. 14.
      "Evi1 is a survival factor which conveys resistance to both TGFbeta- and taxol-mediated cell death via PI3K/AKT."
      Liu Y. , Chen L. , Ko T.C. , Fields A.P. , Thompson E.A.
      Oncogene25:3565-3575(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN APOPTOSIS
    15. 15.
      "Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
      Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
      J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "Pbx1 is a downstream target of Evi-1 in hematopoietic stem/progenitors and leukemic cells."
      Shimabe M. , Goyama S. , Watanabe-Okochi N. , Yoshimi A. , Ichikawa M. , Imai Y. , Kurokawa M.
      Oncogene28:4364-4374(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    17. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-860;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
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