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Index > Protein center > EVI5(Gene name) > Human
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  • EVI5 (Gene name),
  • Ecotropic viral integration site 5 protein homolog (Protein name ),  EVI5_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EVI5(NB4S);
    Protein name:
    Ecotropic viral integration site 5 protein homolog(EVI-5);
    Alternative:
    Neuroblastoma stage 4S gene protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Dimeric and monomeric. Interacts with alpha- and gamma-tubulin. Interacts with FBXO5. Interacts with the chromosome passenger complex (CPC) which is at least composed of AURKB/aurora-B, BIRC5/survivin, CDCA8/borealin and INCENP.
    Function:
    Functions as a regulator of cell cycle progression by stabilizing the FBXO5 protein and promoting cyclin-A accumulation during interphase. May play a role in cytokinesis.
    Subcellular Location:
    Nucleus Cytoplasm cytoskeleton centrosome Cytoplasm cytoskeleton spindle Associates with the mitotic spindle through anaphase and remains within the midzone and midbody until completion of cytokinesis.
    Protein Attributes:
    Sequence length:
    810
    Sequence:
    50:
    MVTNKMTAAF | RNPSGKQVAT | DKVAEKLSST | LSWVKNTVSH | TVSQMASQVA | 
    100:
    SPSTSLHTTS | SSTTLSTPAL | SPSSPSQLSP | DDLELLAKLE | EQNRLLETDS | 
    150:
    KSLRSVNGSR | RNSGSSLVSS | SSASSNLSHL | EEDSWILWGR | IVNEWEDVRK | 
    200:
    KKEKQVKELV | HKGIPHHFRA | IVWQLLCSAQ | SMPIKDQYSE | LLKMTSPCEK | 
    250:
    LIRRDIARTY | PEHNFFKEKD | SLGQEVLFNV | MKAYSLVDRE | VGYCQGSAFI | 
    300:
    VGLLLMQMPE | EEAFCVFVKL | MQDYRLRELF | KPSMAELGLC | MYQFECMIQE | 
    350:
    HLPELFVHFQ | SQSFHTSMYA | SSWFLTIFLT | TFPLPIATRI | FDIFMSEGLE | 
    400:
    IVFRVGLALL | QMNQAELMQL | DMEGMLQHFQ | KVIPHQFDGV | PDKLIQAAYQ | 
    450:
    VKYNSKKMKK | LEKEYTTIKT | KEMEEQVEIK | RLRTENRLLK | QRIETLEKHK | 
    500:
    CSSNYNEDFV | LQLEKELVQA | RLSEAESQCA | LKEMQDKVLD | IEKRNNSLPD | 
    550:
    ENNIARLQEE | LIAVKLREAE | AIMGLKELRQ | QVKDLEEHWQ | RHLARTTGRW | 
    600:
    KDPPKKNAMN | ELQDELMTIR | LREAETQAEI | REIKQRMMEM | ETQNQINSNH | 
    650:
    LRRAEQEVIS | LQEKVQYLSA | QNKGLLTQLS | EAKRKQAEIE | CKNKEEVMAV | 
    700:
    RLREADSIAA | VAELRQHIAE | LEIQKEEGKL | QGQLNKSDSN | QYIGELKDQI | 
    750:
    AELNHELRCL | KGQRGFSGQP | PFDGIHIVNH | LIGDDESFHS | SDEDFIDNSL | 
    800:
    QETGVGFPLH | GKSGSMSLDP | AVADGSESET | EDSVLETRES | NQVVQKERPP | 
    810:
    RRRESYSTTV | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    KEGG:
    UniGene:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human EVI-5
    ELISA Kit for Human EVI-5
    CLIA Kit for Human EVI-5
    CLIA Kit for Human EVI-5
    Polyclonal Antibody for Human EVI-5
    Polyclonal Antibody for Human EVI-5
    Monoclonal Antibody for Human EVI-5
    Monoclonal Antibody for Human EVI-5
    Protein for Human EVI-5
    Protein for Human EVI-5

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "NB4S, a member of the TBC1 domain family of genes, is truncated as a result of a constitutional t(1;10)(p22;q21) chromosome translocation in a patient with stage 4S neuroblastoma."
      Roberts T. , Chernova O. , Cowell J.K.
      Hum. Mol. Genet.7:1169-1178(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);TISSUE SPECIFICITY;DISEASE;CHROMOSOMAL TRANSLOCATION WITH TRNG10;VARIANTS VAL-82 AND VAL-336
      tissue: Brain.
    2. 2.
      "Identification and characterization of a novel Tre-2/Bub2/Cdc16 (TBC) protein that possesses Rab3A-GAP activity."
      Ishibashi K. , Kanno E. , Itoh T. , Fukuda M.
      Genes Cells14:41-52(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);VARIANTS VAL-82 AND VAL-336
    3. 3.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "EVI5 is a novel centrosomal protein that binds to alpha- and gamma-tubulin."
      Faitar S.L. , Dabbeekeh J.T.S. , Ranalli T.A. , Cowell J.K.
      Genomics86:594-605(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;OLIGOMERIZATION;SUBCELLULAR LOCATION;INTERACTION WITH ALPHA-TUBULIN AND GAMMA-TUBULIN
    5. 5.
      "The evi5 oncogene regulates cyclin accumulation by stabilizing the anaphase-promoting complex inhibitor emi1."
      Eldridge A.G. , Loktev A.V. , Hansen D.V. , Verschuren E.W. , Reimann J.D.R. , Jackson P.K.
      Cell124:367-380(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH FBXO5;INDUCTION;UBIQUITINATION;SUBCELLULAR LOCATION;PHOSPHORYLATION BY PLK1
    6. 6.
      "EVI5 protein associates with the INCENP-aurora B kinase-survivin chromosomal passenger complex and is involved in the completion of cytokinesis."
      Faitar S.L. , Sossey-Alaoui K. , Ranalli T.A. , Cowell J.K.
      Exp. Cell Res.312:2325-2335(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH AURKB; BIRC5 AND INCENP;SUBCELLULAR LOCATION
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-776;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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