Evl ELISA Kit for Mouse(Mus musculus) | EIAab.comEvl ELISA Kit for Mouse(Mus musculus)

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Evl (Gene name),

Ena/VASP-like protein (Protein name ), EVL_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Evl;

Protein name:

Ena/VASP-like protein;

Alternative:

Ena/vasodilator-stimulated phosphoprotein-like;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer (By similarity). Binds to the SH3 domains of ABL1, LYN and SRC. Also binds to profilin, with preference for isoform IIa of PFN2, and the WW domain of APBB1/FE65. Binds to SEMA6A. Interacts, via the Pro-rich region, with the C-terminal SH3 domain of DNMBP. Interacts with RAPH1. Binds, via the EVH1 domain, the Pro-rich domain of ZYX (By similarity). Binds, via the EVH1 domain, the Pro-rich domain of Listeria monocytogenes actA.

Function:

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance and lamellipodial and filopodial dynamics in migrating cells. EVL enhances actin nucleation and polymerization. Required to transform actin polymerization into active movement for the propulsive force of Listeria monocytogenes.

Subcellular Location:

Cytoplasm cytoskeleton Cell projection lamellipodium Targeted to the leading edge of lamellipodia and the dital tip of stress fibers through interaction with a number of proteins. In activated T-cells, localizes to the F-actin collar and the distal tip of microspikes.

Protein Attributes:

Sequence length:

414

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

414:

IDAIRQELSG | ISTT

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

P70429

UniGene:

Mm.238841

Pfam:

PF08776

Pfam:

PF11643

SMR:

P70429

KEGG:

mmu:14026

Uniprot:

P70429

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ELISA Kit for Mouse Ena/VASP-like protein

CLIA Kit for Mouse Ena/VASP-like protein

Polyclonal Antibody for Mouse Ena/VASP-like protein

Monoclonal Antibody for Mouse Ena/VASP-like protein

Protein for Mouse Ena/VASP-like protein

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Mena, a relative of VASP and Drosophila Enabled, is implicated in the control of microfilament dynamics."
Gertler F.B. , Niebuhr K. , Reinhard M. , Wehland J. , Soriano P.
Cell87:227-239(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Brain.
2.

"cAMP-dependent protein kinase phosphorylation of EVL, a Mena/VASP relative, regulates its interaction with actin and SH3 domains."
Lambrechts A. , Kwiatkowski A.V. , Lanier L.M. , Bear J.E. , Vandekerckhove J. , Ampe C. , Gertler F.B.
J. Biol. Chem.275:36143-36151(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);FUNCTION;INTERACTION WITH PFN2; LYN; APBB1; ABL1 AND SRC;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;PHOSPHORYLATION BY PKA
strain: C57BL/6J.
3.

"Role of proteins of the Ena/VASP family in actin-based motility of Listeria monocytogenes."
Laurent V. , Loisel T.P. , Harbeck B. , Wehman A. , Groebe L. , Jockusch B.M. , Wehland J. , Gertler F.B. , Carlier M.-F.
J. Cell Biol.144:1245-1258(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ROLE IN L.MONOCYTOGENES MOBILITY;MISCELLANEOUS;INTERACTION WITH L.MONOCYTOGENES ACTA
4.

"Mena is required for neurulation and commissure formation."
Lanier L.M. , Gates M.A. , Witke W. , Menzies A.S. , Wehman A.M. , Macklis J.D. , Kwiatkowski D. , Soriano P. , Gertler F.B.
Neuron22:313-325(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DEVELOPMENTAL STAGE;TISSUE SPECIFICITY
5.

"The orthologous human and murine semaphorin 6A-1 proteins (SEMA6A-1/Sema6A-1) bind to the enabled/vasodilator-stimulated phosphoprotein-like protein (EVL) via a novel carboxyl-terminal zyxin-like domain."
Klostermann A. , Lutz B. , Gertler F. , Behl C.
J. Biol. Chem.275:39647-39653(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SEMA6A
6.

"Tuba, a novel protein containing bin/amphiphysin/Rvs and Dbl homology domains, links dynamin to regulation of the actin cytoskeleton."
Salazar M.A. , Kwiatkowski A.V. , Pellegrini L. , Cestra G. , Butler M.H. , Rossman K.L. , Serna D.M. , Sondek J. , Gertler F.B. , De Camilli P.
J. Biol. Chem.278:49031-49043(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNMBP
7.

"The phagosomal proteome in interferon-gamma-activated macrophages."
Trost M. , English L. , Lemieux S. , Courcelles M. , Desjardins M. , Thibault P.
Immunity30:143-154(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-367;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
8.

"Structure of EVH1, a novel proline-rich ligand-binding module involved in cytoskeletal dynamics and neural function."
Fedorov A.A. , Fedorov E. , Gertler F. , Almo S.C.
Nat. Struct. Biol.6:661-665(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 1-130 IN COMPLEX WITH A SYNTHETIC PRO-RICH PEPTIDE

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