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Index > Protein center > EXOSC8(Gene name) > Human
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  • EXOSC8 (Gene name),
  • Exosome complex component RRP43 (Protein name ),  EXOS8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EXOSC8(OIP2;RRP43);
    Protein name:
    Exosome complex component RRP43;
    Alternative:
    Opa-interacting protein 2(OIP-2);Exosome component 8;p9;Ribosomal RNA-processing protein 43;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the RNA exosome complex. Specifically part of the catalytically inactive RNA exosome core (Exo-9) complex which is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms. Exo-9 is formed by a hexameric ring of RNase PH domain-containing subunits specifically containing the heterodimers EXOSC4-EXOSC9, EXOSC5-EXOSC8 and EXOSC6-EXOSC7, and peripheral S1 domain-containing components EXOSC1, EXOSC2 and EXOSC3 located on the top of the ring structure. Binds outer membrane protein opap from Neisseria gonorrhoeae.
    Function:
    Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as anti-sense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC8 binds to ARE-containing RNAs.
    Subcellular Location:
    Cytoplasm Nucleus Nucleus nucleolus
    Protein Attributes:
    Sequence length:
    276
    Sequence:
    50:
    MAAGFKTVEP | LEYYRRFLKE | NCRPDGRELG | EFRTTTVNIG | SISTADGSAL | 
    100:
    VKLGNTTVIC | GVKAEFAAPS | TDAPDKGYVV | PNVDLPPLCS | SRFRSGPPGE | 
    150:
    EAQVASQFIA | DVIENSQIIQ | KEDLCISPGK | LVWVLYCDLI | CLDYDGNILD | 
    200:
    ACTFALLAAL | KNVQLPEVTI | NEETALAEVN | LKKKSYLNIR | THPVATSFAV | 
    250:
    FDDTLLIVDP | TGEEEHLATG | TLTIVMDEEG | KLCCLHKPGG | SGLTGAKLQD | 
    276:
    CMSRAVTRHK | EVKKLMDEVI | KSMKPK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    SMR:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Exosome complex component RRP43
    ELISA Kit for Human Exosome complex component RRP43
    ELISA Kit for Human Exosome complex component RRP43
    CLIA Kit for Human Exosome complex component RRP43
    CLIA Kit for Human Exosome complex component RRP43
    CLIA Kit for Human Exosome complex component RRP43
    Polyclonal Antibody for Human Exosome complex component RRP43
    Polyclonal Antibody for Human Exosome complex component RRP43
    Polyclonal Antibody for Human Exosome complex component RRP43
    Monoclonal Antibody for Human Exosome complex component RRP43
    Monoclonal Antibody for Human Exosome complex component RRP43
    Monoclonal Antibody for Human Exosome complex component RRP43
    Protein for Human Exosome complex component RRP43
    Protein for Human Exosome complex component RRP43
    Protein for Human Exosome complex component RRP43

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    Precision
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    Linearity
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    References
    1. 1.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Uterus.
    4. 4.
      "Using the yeast two-hybrid system to identify human epithelial cell proteins that bind gonococcal Opa proteins: intracellular gonococci bind pyruvate kinase via their Opa proteins and require host pyruvate for growth."
      Williams J.M. , Chen G.-C. , Zhu L. , Rest R.F.
      Mol. Microbiol.27:171-186(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 3-276
    5. 5.
      "AU binding proteins recruit the exosome to degrade ARE-containing mRNAs."
      Chen C.-Y. , Gherzi R. , Ong S.-E. , Chan E.L. , Raijmakers R. , Pruijn G.J.M. , Stoecklin G. , Moroni C. , Mann M. , Karin M.
      Cell107:451-464(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;IDENTIFICATION IN THE RNA EXOSOME CORE COMPLEX
    6. 6.
      "Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring."
      Raijmakers R. , Vree Egberts W. , van Venrooij W.J. , Pruijn G.J.M.
      J. Mol. Biol.323:653-663(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN INTERACTION
    7. 7.
      "A protein interaction framework for human mRNA degradation."
      Lehner B. , Sanderson C.M.
      Genome Res.14:1315-1323(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN INTERACTION
    8. 8.
      "Sequence-specific RNA binding mediated by the RNase PH domain of components of the exosome."
      Anderson J.R. , Mukherjee D. , Muthukumaraswamy K. , Moraes K.C. , Wilusz C.J. , Wilusz J.
      RNA12:1810-1816(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN ARE-CONTAINING MRNA-BINDING
    9. 9.
      "Human cell growth requires a functional cytoplasmic exosome, which is involved in various mRNA decay pathways."
      van Dijk E.L. , Schilders G. , Pruijn G.J.
      RNA13:1027-1035(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MRNA DEGRADATION;SUBCELLULAR LOCATION
    10. 10.
      "Dis3-like 1: a novel exoribonuclease associated with the human exosome."
      Staals R.H. , Bronkhorst A.W. , Schilders G. , Slomovic S. , Schuster G. , Heck A.J. , Raijmakers R. , Pruijn G.J.
      EMBO J.29:2358-2367(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE RNA EXOSOME COMPLEX;IDENTIFICATION BY MASS SPECTROMETRY
    11. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    13. 13.
      "Reconstitution, activities, and structure of the eukaryotic RNA exosome."
      Liu Q. , Greimann J.C. , Lima C.D.
      Cell127:1223-1237(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.35 ANGSTROMS);LACK OF CATALYTIC ACTIVITY;RECONSTITUTION OF THE RNA EXOSOME CORE COMPLEX
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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