Eya1 ELISA Kit for Mouse(Mus musculus) | EIAab.comEya1 ELISA Kit for Mouse(Mus musculus)

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Index > Protein center > Eya1(Gene name) > Mouse

Eya1 (Gene name),

Eyes absent homolog 1 (Protein name ), EYA1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Eya1;

Protein name:

Eyes absent homolog 1;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Probably interacts with SIX2, SIX4 and SIX5.

Function:

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Seems to coactivate SIX2, SIX4 and SIX5. May be involved in development of the eye. May play a role in mediating the induction and differentiation of cranial placodes.

Subcellular Location:

Cytoplasm Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).

Protein Attributes:

Sequence length:

591

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

591:

LLIGDGVEEE | QGAKKHAMPF | WRVSSHSDLM | ALHHALELEY | L

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00702

SMR:

P97767

String:

P97767

UniGene:

Mm.250185

Uniprot:

P97767

FOR

ELISA Kit for Mouse Eyes absent homolog 1

CLIA Kit for Mouse Eyes absent homolog 1

Polyclonal Antibody for Mouse Eyes absent homolog 1

Monoclonal Antibody for Mouse Eyes absent homolog 1

Protein for Mouse Eyes absent homolog 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode."
Xu P.-X. , Woo I. , Her H. , Beier D.R. , Maas R.L.
Development124:219-231(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Embryo.
2.

"A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family."
Abdelhak S. , Kalatzis V. , Heilig R. , Compain S. , Samson D. , Vincent C. , Weil D. , Cruaud C. , Sahly I. , Leibovici M. , Bitner-Glindzicz M. , Francis M. , Lacombe D. , Vigneron J. , Charachon R. , Boven K. , Bedbeder P. , van Regemorter N. , more...
Nat. Genet.15:157-164(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 2)
strain: CB/20.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"Inner ear and kidney anomalies caused by IAP insertion in an intron of the Eya1 gene in a mouse model of BOR syndrome."
Johnson K.R. , Cook S.A. , Erway L.C. , Matthews A.N. , Sanford L.P. , Paradies N.E. , Friedman R.A.
Hum. Mol. Genet.8:645-653(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 276-321;DISEASE
strain: 129/SvJ.
6.

"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G. , DeGrandi A. , Ballabio A. , Bulfone A. , Bernard L. , Banfi S. , Gattuso C. , Mariani M. , Dixon M. , Donnai D. , Metcalfe K. , Winter R. , Robertson M. , Axton R. , Brown A. , van Heyningen V. , Hanson I.
Hum. Mol. Genet.8:11-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 431-549
tissue: Embryo.
7.

"Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
Ohto H. , Kamada S. , Tago K. , Tominaga S. , Ozaki H. , Sato S. , Kawakami K.
Mol. Cell. Biol.19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SIX2; SIX4 AND SIX5;SUBCELLULAR LOCATION
8.

"Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia."
Xu P.X. , Adams J. , Peters H. , Brown M.C. , Heaney S. , Maas R.
Nat. Genet.23:113-117(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION
9.

"Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis."
Li X. , Oghi K.A. , Zhang J. , Krones A. , Bush K.T. , Glass C.K. , Nigam S.K. , Aggarwal A.K. , Maas R. , Rose D.W. , Rosenfeld M.G.
Nature426:247-254(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;DISRUPTION PHENOTYPE
10.

Li X. , Oghi K.A. , Zhang J. , Krones A. , Bush K.T. , Glass C.K. , Nigam S.K. , Aggarwal A.K. , Maas R. , Rose D.W. , Rosenfeld M.G.
Nature427:265-265(2004)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
11.

"Eyes absent represents a class of protein tyrosine phosphatases."
Rayapureddi J.P. , Kattamuri C. , Steinmetz B.D. , Frankfort B.J. , Ostrin E.J. , Mardon G. , Hegde R.S.
Nature426:295-298(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
12.

"Pax6-dependence of Six3, Eya1 and Dach1 expression during lens and nasal placode induction."
Purcell P. , Oliver G. , Mardon G. , Donner A.L. , Maas R.L.
Gene Expr. Patterns6:110-118(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIX3
13.

"SUMO1 haploinsufficiency leads to cleft lip and palate."
Alkuraya F.S. , Saadi I. , Lund J.J. , Turbe-Doan A. , Morton C.C. , Maas R.L.
Science313:1751-1751(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION;MUTAGENESIS OF LYS-43 AND LYS-459
14.

"Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo."
Grifone R. , Demignon J. , Giordani J. , Niro C. , Souil E. , Bertin F. , Laclef C. , Xu P.X. , Maire P.
Dev. Biol.302:602-616(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
15.

"Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions."
Cook P.J. , Ju B.G. , Telese F. , Wang X. , Glass C.K. , Rosenfeld M.G.
Nature458:591-596(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH H2AX

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