Eya2 ELISA Kit for Mouse(Mus musculus) | EIAab.comEya2 ELISA Kit for Mouse(Mus musculus)

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Eya2 (Gene name),

Eyes absent homolog 2 (Protein name ), EYA2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Eya2(Eab1);

Protein name:

Eyes absent homolog 2;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SIX1, and probably with SIX2, SIX4 and SIX5. Interacts with GNAZ, GNAI2 and DACH2 (By similarity). Interacts with CAPN8.

Function:

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. Together with SIX1 and DACH2 seem to be involved in myogenesis. May be involved in development of the eye. Interaction with GNAZ and GNAI2 prevents nuclear translocation and transcriptional activity.

Subcellular Location:

Cytoplasm Nucleus

Protein Attributes:

Sequence length:

532

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

532:

EQGAKKHNMP | FWRISCHADL | EALRHALELE | YL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.282719

Pfam:

PF00702

SMR:

O08575

String:

O08575

KEGG:

mmu:14049

Uniprot:

O08575

FOR

ELISA Kit for Mouse Eyes absent homolog 2

CLIA Kit for Mouse Eyes absent homolog 2

Polyclonal Antibody for Mouse Eyes absent homolog 2

Monoclonal Antibody for Mouse Eyes absent homolog 2

Protein for Mouse Eyes absent homolog 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode."
Xu P.-X. , Woo I. , Her H. , Beier D.R. , Maas R.L.
Development124:219-231(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Embryo.
2.

"Eyes absent: a gene family found in several metazoan phyla."
Duncan M.K. , Kos L. , Jenkins N.A. , Gilbert D.J. , Copeland N.G. , Tomarev S.I.
Mamm. Genome8:479-485(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Embryo.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain: C57BL/6J.
tissue: Mammary gland.
5.

"Identification of transcriptional targets for Six5: implication for the pathogenesis of myotonic dystrophy type 1."
Sato S. , Nakamura M. , Cho D.H. , Tapscott S.J. , Ozaki H. , Kawakami K.
Hum. Mol. Genet.11:1045-1058(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIX1
6.

"Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene."
Zimmerman J.E. , Bui Q.T. , Steingrimsson E. , Nagle D.L. , Fu W. , Genin A. , Spinner N.B. , Copeland N.G. , Jenkins N.A. , Bucan M. , Bonini N.M.
Genome Res.7:128-141(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 60-532
tissue: Embryo.
7.

"Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
Ohto H. , Kamada S. , Tago K. , Tominaga S. , Ozaki H. , Sato S. , Kawakami K.
Mol. Cell. Biol.19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SIX2; SIX4 AND SIX5;SUBCELLULAR LOCATION
8.

"Eyes absent represents a class of protein tyrosine phosphatases."
Rayapureddi J.P. , Kattamuri C. , Steinmetz B.D. , Frankfort B.J. , Ostrin E.J. , Mardon G. , Hegde R.S.
Nature426:295-298(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY
9.

"Stomach-specific calpain, nCL-2, localizes in mucus cells and proteolyzes the beta-subunit of coatomer complex, beta-COP."
Hata S. , Koyama S. , Kawahara H. , Doi N. , Maeda T. , Toyama-Sorimachi N. , Abe K. , Suzuki K. , Sorimachi H.
J. Biol. Chem.281:11214-11224(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CAPN8;TISSUE SPECIFICITY
10.

"Eya1 and Eya2 proteins are required for hypaxial somitic myogenesis in the mouse embryo."
Grifone R. , Demignon J. , Giordani J. , Niro C. , Souil E. , Bertin F. , Laclef C. , Xu P.X. , Maire P.
Dev. Biol.302:602-616(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE;FUNCTION

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