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Index > Protein center > EYA3(Gene name) > Human
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  • EYA3 (Gene name),
  • Eyes absent homolog 3 (Protein name ),  EYA3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    EYA3;
    Protein name:
    Eyes absent homolog 3;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with SIX1 and DACH1, and probably SIX2, SIX4, SIX5.
    Function:
    Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
    Subcellular Location:
    Cytoplasm Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively.
    Protein Attributes:
    Sequence length:
    573
    Sequence:
    50:
    MEEEQDLPEQ | PVKKAKMQES | GEQTISQVSN | PDVSDQKPET | SSLASNLPMS | 
    100:
    EEIMTCTDYI | PRSSNDYTSQ | MYSAKPYAHI | LSVPVSETAY | PGQTQYQTLQ | 
    150:
    QTQPYAVYPQ | ATQTYGLPPF | GALWPGMKPE | SGLIQTPSPS | QHSVLTCTTG | 
    200:
    LTTSQPSPAH | YSYPIQASST | NASLISTSST | IANIPAAAVA | SISNQDYPTY | 
    250:
    TILGQNQYQA | CYPSSSFGVT | GQTNSDAEST | TLAATTYQSE | KPSVMAPAPA | 
    300:
    AQRLSSGDPS | TSPSLSQTTP | SKDTDDQSRK | NMTSKNRGKR | KADATSSQDS | 
    350:
    ELERVFLWDL | DETIIIFHSL | LTGSYAQKYG | KDPTVVIGSG | LTMEEMIFEV | 
    400:
    ADTHLFFNDL | EECDQVHVED | VASDDNGQDL | SNYSFSTDGF | SGSGGSGSHG | 
    450:
    SSVGVQGGVD | WMRKLAFRYR | KVREIYDKHK | SNVGGLLSPQ | RKEALQRLRA | 
    500:
    EIEVLTDSWL | GTALKSLLLI | QSRKNCVNVL | ITTTQLVPAL | AKVLLYGLGE | 
    550:
    IFPIENIYSA | TKIGKESCFE | RIVSRFGKKV | TYVVIGDGRD | EEIAAKQHNM | 
    573:
    PFWRITNHGD | LVSLHQALEL | DFL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    SMR:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Eyes absent homolog 3
    ELISA Kit for Human Eyes absent homolog 3
    ELISA Kit for Human Eyes absent homolog 3
    CLIA Kit for Human Eyes absent homolog 3
    CLIA Kit for Human Eyes absent homolog 3
    CLIA Kit for Human Eyes absent homolog 3
    Polyclonal Antibody for Human Eyes absent homolog 3
    Polyclonal Antibody for Human Eyes absent homolog 3
    Polyclonal Antibody for Human Eyes absent homolog 3
    Monoclonal Antibody for Human Eyes absent homolog 3
    Monoclonal Antibody for Human Eyes absent homolog 3
    Monoclonal Antibody for Human Eyes absent homolog 3
    Protein for Human Eyes absent homolog 3
    Protein for Human Eyes absent homolog 3
    Protein for Human Eyes absent homolog 3

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family."
      Abdelhak S. , Kalatzis V. , Heilig R. , Compain S. , Samson D. , Vincent C. , Weil D. , Cruaud C. , Sahly I. , Leibovici M. , Bitner-Glindzicz M. , Francis M. , Lacombe D. , Vigneron J. , Charachon R. , Boven K. , Bedbeder P. , van Regemorter N. , more...
      Nat. Genet.15:157-164(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
      tissue: Embryo.
    2. 2.
      "Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene."
      Zimmerman J.E. , Bui Q.T. , Steingrimsson E. , Nagle D.L. , Fu W. , Genin A. , Spinner N.B. , Copeland N.G. , Jenkins N.A. , Bucan M. , Bonini N.M.
      Genome Res.7:128-141(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Retina.
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5)
      tissue: Brain.
      tissue: Hippocampus.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
      tissue: Brain.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 413-531
    8. 8.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    9. 9.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 10.
      "Dephosphorylation of the C-terminal tyrosyl residue of the DNA damage-related histone H2A.X is mediated by the protein phosphatase eyes absent."
      Krishnan N. , Jeong D.G. , Jung S.-K. , Ryu S.E. , Xiao A. , Allis C.D. , Kim S.J. , Tonks N.K.
      J. Biol. Chem.284:16066-16070(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
    11. 11.
      "Tyrosine dephosphorylation of H2AX modulates apoptosis and survival decisions."
      Cook P.J. , Ju B.G. , Telese F. , Wang X. , Glass C.K. , Rosenfeld M.G.
      Nature458:591-596(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-266;MUTAGENESIS OF SER-266 AND ASP-309
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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