Protein name:
Eyes absent homolog 3 ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with SIX1 and DACH1, and probably SIX2, SIX4, SIX5.
Function:
Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1. Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. Coactivates SIX1, and seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity (By similarity). May be involved in development of the eye.
Subcellular Location:
Cytoplasm
Nucleus
Localizes at sites of DNA damage at double-strand breaks (DSBs). With decreasing efficiency, translocalized to the nucleus by SIX2 and SIX5, and SIX4, respectively.
Protein Attributes:
50:
MEEEQDLPEQ | PVKKAKMQES | GEQTISQVSN | PDVSDQKPET | SSLASNLPMS |
100:
EEIMTCTDYI | PRSSNDYTSQ | MYSAKPYAHI | LSVPVSETAY | PGQTQYQTLQ |
150:
QTQPYAVYPQ | ATQTYGLPPF | GALWPGMKPE | SGLIQTPSPS | QHSVLTCTTG |
200:
LTTSQPSPAH | YSYPIQASST | NASLISTSST | IANIPAAAVA | SISNQDYPTY |
250:
TILGQNQYQA | CYPSSSFGVT | GQTNSDAEST | TLAATTYQSE | KPSVMAPAPA |
300:
AQRLSSGDPS | TSPSLSQTTP | SKDTDDQSRK | NMTSKNRGKR | KADATSSQDS |
350:
ELERVFLWDL | DETIIIFHSL | LTGSYAQKYG | KDPTVVIGSG | LTMEEMIFEV |
400:
ADTHLFFNDL | EECDQVHVED | VASDDNGQDL | SNYSFSTDGF | SGSGGSGSHG |
450:
SSVGVQGGVD | WMRKLAFRYR | KVREIYDKHK | SNVGGLLSPQ | RKEALQRLRA |
500:
EIEVLTDSWL | GTALKSLLLI | QSRKNCVNVL | ITTTQLVPAL | AKVLLYGLGE |
550:
IFPIENIYSA | TKIGKESCFE | RIVSRFGKKV | TYVVIGDGRD | EEIAAKQHNM |
573:
PFWRITNHGD | LVSLHQALEL | DFL
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Chicken
Human
ELISA Kit for Human Eyes absent homolog 3
ELISA Kit for Human Eyes absent homolog 3
ELISA Kit for Human Eyes absent homolog 3
CLIA Kit for Human Eyes absent homolog 3
CLIA Kit for Human Eyes absent homolog 3
CLIA Kit for Human Eyes absent homolog 3
Polyclonal Antibody for Human Eyes absent homolog 3
Polyclonal Antibody for Human Eyes absent homolog 3
Polyclonal Antibody for Human Eyes absent homolog 3
Monoclonal Antibody for Human Eyes absent homolog 3
Monoclonal Antibody for Human Eyes absent homolog 3
Monoclonal Antibody for Human Eyes absent homolog 3
Protein for Human Eyes absent homolog 3
Protein for Human Eyes absent homolog 3
Protein for Human Eyes absent homolog 3
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Recovery
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Linearity
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
References
1.
"A human homologue of the Drosophila eyes absent gene underlies branchio-oto-renal (BOR) syndrome and identifies a novel gene family."
Abdelhak S.
,
Kalatzis V.
,
Heilig R.
,
Compain S.
,
Samson D.
,
Vincent C.
,
Weil D.
,
Cruaud C.
,
Sahly I.
,
Leibovici M.
,
Bitner-Glindzicz M.
,
Francis M.
,
Lacombe D.
,
Vigneron J.
,
Charachon R.
,
Boven K.
,
Bedbeder P.
,
van Regemorter N.
,
Weissenbach J.
,
Petit C.
more...
Nat. Genet.15:157-164(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1)
tissue :
Embryo .
2.
"Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene."
Zimmerman J.E.
,
Bui Q.T.
,
Steingrimsson E.
,
Nagle D.L.
,
Fu W.
,
Genin A.
,
Spinner N.B.
,
Copeland N.G.
,
Jenkins N.A.
,
Bucan M.
,
Bonini N.M.
Genome Res.7:128-141(1997)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue :
Retina .
3.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T.
,
Suzuki Y.
,
Nishikawa T.
,
Otsuki T.
,
Sugiyama T.
,
Irie R.
,
Wakamatsu A.
,
Hayashi K.
,
Sato H.
,
Nagai K.
,
Kimura K.
,
Makita H.
,
Sekine M.
,
Obayashi M.
,
Nishi T.
,
Shibahara T.
,
Tanaka T.
,
Ishii S.
,
Yamamoto J.
,
Saito K.
,
Kawai Y.
,
Isono Y.
,
Nakamura Y.
,
Nagahari K.
,
Murakami K.
,
Yasuda T.
,
Iwayanagi T.
,
Wagatsuma M.
,
Shiratori A.
,
Sudo H.
,
Hosoiri T.
,
Kaku Y.
,
Kodaira H.
,
Kondo H.
,
Sugawara M.
,
Takahashi M.
,
Kanda K.
,
Yokoi T.
,
Furuya T.
,
Kikkawa E.
,
Omura Y.
,
Abe K.
,
Kamihara K.
,
Katsuta N.
,
Sato K.
,
Tanikawa M.
,
Yamazaki M.
,
Ninomiya K.
,
Ishibashi T.
,
Yamashita H.
,
Murakawa K.
,
Fujimori K.
,
Tanai H.
,
Kimata M.
,
Watanabe M.
,
Hiraoka S.
,
Chiba Y.
,
Ishida S.
,
Ono Y.
,
Takiguchi S.
,
Watanabe S.
,
Yosida M.
,
Hotuta T.
,
Kusano J.
,
Kanehori K.
,
Takahashi-Fujii A.
,
Hara H.
,
Tanase T.-O.
,
Nomura Y.
,
Togiya S.
,
Komai F.
,
Hara R.
,
Takeuchi K.
,
Arita M.
,
Imose N.
,
Musashino K.
,
Yuuki H.
,
Oshima A.
,
Sasaki N.
,
Aotsuka S.
,
Yoshikawa Y.
,
Matsunawa H.
,
Ichihara T.
,
Shiohata N.
,
Sano S.
,
Moriya S.
,
Momiyama H.
,
Satoh N.
,
Takami S.
,
Terashima Y.
,
Suzuki O.
,
Nakagawa S.
,
Senoh A.
,
Mizoguchi H.
,
Goto Y.
,
Shimizu F.
,
Wakebe H.
,
Hishigaki H.
,
Watanabe T.
,
Sugiyama A.
,
Takemoto M.
,
Kawakami B.
,
Yamazaki M.
,
Watanabe K.
,
Kumagai A.
,
Itakura S.
,
Fukuzumi Y.
,
Fujimori Y.
,
Komiyama M.
,
Tashiro H.
,
Tanigami A.
,
Fujiwara T.
,
Ono T.
,
Yamada K.
,
Fujii Y.
,
Ozaki K.
,
Hirao M.
,
Ohmori Y.
,
Kawabata A.
,
Hikiji T.
,
Kobatake N.
,
Inagaki H.
,
Ikema Y.
,
Okamoto S.
,
Okitani R.
,
Kawakami T.
,
Noguchi S.
,
Itoh T.
,
Shigeta K.
,
Senba T.
,
Matsumura K.
,
Nakajima Y.
,
Mizuno T.
,
Morinaga M.
,
Sasaki M.
,
Togashi T.
,
Oyama M.
,
Hata H.
,
Watanabe M.
,
Komatsu T.
,
Mizushima-Sugano J.
,
Satoh T.
,
Shirai Y.
,
Takahashi Y.
,
Nakagawa K.
,
Okumura K.
,
Nagase T.
,
Nomura N.
,
Kikuchi H.
,
Masuho Y.
,
Yamashita R.
,
Nakai K.
,
Yada T.
,
Nakamura Y.
,
Ohara O.
,
Isogai T.
,
Sugano S.
more...
Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 4 AND 5)
tissue :
Brain .
tissue :
Hippocampus .
4.
"The DNA sequence and biological annotation of human chromosome 1."
Gregory S.G.
,
Barlow K.F.
,
McLay K.E.
,
Kaul R.
,
Swarbreck D.
,
Dunham A.
,
Scott C.E.
,
Howe K.L.
,
Woodfine K.
,
Spencer C.C.A.
,
Jones M.C.
,
Gillson C.
,
Searle S.
,
Zhou Y.
,
Kokocinski F.
,
McDonald L.
,
Evans R.
,
Phillips K.
,
Atkinson A.
,
Cooper R.
,
Jones C.
,
Hall R.E.
,
Andrews T.D.
,
Lloyd C.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Anderson F.
,
Andrew R.W.
,
Ashwell R.I.S.
,
Aubin K.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Beasley H.
,
Bethel G.
,
Bird C.P.
,
Bray-Allen S.
,
Brown J.Y.
,
Brown A.J.
,
Buckley D.
,
Burton J.
,
Bye J.
,
Carder C.
,
Chapman J.C.
,
Clark S.Y.
,
Clarke G.
,
Clee C.
,
Cobley V.
,
Collier R.E.
,
Corby N.
,
Coville G.J.
,
Davies J.
,
Deadman R.
,
Dunn M.
,
Earthrowl M.
,
Ellington A.G.
,
Errington H.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Gay L.
,
Ghori M.R.J.
,
Gibson R.
,
Gilby L.M.
,
Gillett W.
,
Glithero R.J.
,
Grafham D.V.
,
Griffiths C.
,
Griffiths-Jones S.
,
Grocock R.
,
Hammond S.
,
Harrison E.S.I.
,
Hart E.
,
Haugen E.
,
Heath P.D.
,
Holmes S.
,
Holt K.
,
Howden P.J.
,
Hunt A.R.
,
Hunt S.E.
,
Hunter G.
,
Isherwood J.
,
James R.
,
Johnson C.
,
Johnson D.
,
Joy A.
,
Kay M.
,
Kershaw J.K.
,
Kibukawa M.
,
Kimberley A.M.
,
King A.
,
Knights A.J.
,
Lad H.
,
Laird G.
,
Lawlor S.
,
Leongamornlert D.A.
,
Lloyd D.M.
,
Loveland J.
,
Lovell J.
,
Lush M.J.
,
Lyne R.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Matthews L.
,
Matthews N.S.W.
,
McLaren S.
,
Milne S.
,
Mistry S.
,
Moore M.J.F.
,
Nickerson T.
,
O'Dell C.N.
,
Oliver K.
,
Palmeiri A.
,
Palmer S.A.
,
Parker A.
,
Patel D.
,
Pearce A.V.
,
Peck A.I.
,
Pelan S.
,
Phelps K.
,
Phillimore B.J.
,
Plumb R.
,
Rajan J.
,
Raymond C.
,
Rouse G.
,
Saenphimmachak C.
,
Sehra H.K.
,
Sheridan E.
,
Shownkeen R.
,
Sims S.
,
Skuce C.D.
,
Smith M.
,
Steward C.
,
Subramanian S.
,
Sycamore N.
,
Tracey A.
,
Tromans A.
,
Van Helmond Z.
,
Wall M.
,
Wallis J.M.
,
White S.
,
Whitehead S.L.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams H.
,
Wilming L.
,
Wray P.W.
,
Wu Z.
,
Coulson A.
,
Vaudin M.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Wooster R.
,
Dunham I.
,
Carter N.P.
,
McVean G.
,
Ross M.T.
,
Harrow J.
,
Olson M.V.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature441:315-321(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
Mural R.J.
,
Istrail S.
,
Sutton G.G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue :
Brain .
7.
"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G.
,
DeGrandi A.
,
Ballabio A.
,
Bulfone A.
,
Bernard L.
,
Banfi S.
,
Gattuso C.
,
Mariani M.
,
Dixon M.
,
Donnai D.
,
Metcalfe K.
,
Winter R.
,
Robertson M.
,
Axton R.
,
Brown A.
,
van Heyningen V.
,
Hanson I.
Hum. Mol. Genet.8:11-23(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 413-531
8.
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S.
,
Ballif B.A.
,
Smogorzewska A.
,
McDonald E.R. III
,
Hurov K.E.
,
Luo J.
,
Bakalarski C.E.
,
Zhao Z.
,
Solimini N.
,
Lerenthal Y.
,
Shiloh Y.
,
Gygi S.P.
,
Elledge S.J.
Science316:1160-1166(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic kidney .
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;PHOSPHORYLATION AT SER-266;MUTAGENESIS OF SER-266 AND ASP-309
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-472;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]