Eya3 ELISA Kit for Mouse(Mus musculus) | EIAab.comEya3 ELISA Kit for Mouse(Mus musculus)

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Eya3 (Gene name),

Eyes absent homolog 3 (Protein name ), EYA3_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Eya3;

Protein name:

Eyes absent homolog 3;

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SIX1 and DACH1, and probably SIX2, SIX4 and SIX5.

Function:

Tyrosine phosphatase that specifically dephosphorylates 'Tyr-142' of histone H2AX (H2AXY142ph). 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Promotes efficient DNA repair by dephosphorylating H2AX, promoting the recruitment of DNA repair complexes containing MDC1 (By similarity). Its function as histone phosphatase probably explains its role in transcription regulation during organogenesis. The phosphatase activity has been shown in vitro. Coactivates SIX1. Seems to coactivate SIX2, SIX4 and SIX5. The repression of precursor cell proliferation in myoblasts by SIX1 is switched to activation through recruitment of EYA3 to the SIX1-DACH1 complex and seems to be dependent on EYA3 phosphatase activity. May be involved in development of the eye. May play a role in mediating the induction and differentiation of cranial placodes.

Subcellular Location:

Cytoplasm Nucleus Localizes at sites of DNA damage at double-strand breaks (DSBs).

Protein Attributes:

Sequence length:

510

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

510:

LHQALELDFL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.227733

SMR:

P97480

Pfam:

PF00702

KEGG:

mmu:14050

String:

P97480

Uniprot:

P97480

FOR

ELISA Kit for Mouse Eyes absent homolog 3

CLIA Kit for Mouse Eyes absent homolog 3

Polyclonal Antibody for Mouse Eyes absent homolog 3

Monoclonal Antibody for Mouse Eyes absent homolog 3

Protein for Mouse Eyes absent homolog 3

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning and characterization of two vertebrate homologs of the Drosophila eyes absent gene."
Zimmerman J.E. , Bui Q.T. , Steingrimsson E. , Nagle D.L. , Fu W. , Genin A. , Spinner N.B. , Copeland N.G. , Jenkins N.A. , Bucan M. , Bonini N.M.
Genome Res.7:128-141(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Embryo.
2.

"Mouse Eya homologues of the Drosophila eyes absent gene require Pax6 for expression in lens and nasal placode."
Xu P.-X. , Woo I. , Her H. , Beier D.R. , Maas R.L.
Development124:219-231(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Embryo.
3.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
4.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"EYA4, a novel vertebrate gene related to Drosophila eyes absent."
Borsani G. , DeGrandi A. , Ballabio A. , Bulfone A. , Bernard L. , Banfi S. , Gattuso C. , Mariani M. , Dixon M. , Donnai D. , Metcalfe K. , Winter R. , Robertson M. , Axton R. , Brown A. , van Heyningen V. , Hanson I.
Hum. Mol. Genet.8:11-23(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 350-468
tissue: Embryo.
6.

"Cooperation of six and eya in activation of their target genes through nuclear translocation of Eya."
Ohto H. , Kamada S. , Tago K. , Tominaga S. , Ozaki H. , Sato S. , Kawakami K.
Mol. Cell. Biol.19:6815-6824(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SIX2; SIX4 AND SIX5;SUBCELLULAR LOCATION
7.

"Molecular interaction and synergistic activation of a promoter by Six, Eya, and Dach proteins mediated through CREB binding protein."
Ikeda K. , Watanabe Y. , Ohto H. , Kawakami K.
Mol. Cell. Biol.22:6759-6766(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIX1; SIX2; SIX4 AND SIX5
8.

"Eya protein phosphatase activity regulates Six1-Dach-Eya transcriptional effects in mammalian organogenesis."
Li X. , Oghi K.A. , Zhang J. , Krones A. , Bush K.T. , Glass C.K. , Nigam S.K. , Aggarwal A.K. , Maas R. , Rose D.W. , Rosenfeld M.G.
Nature426:247-254(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;INTERACTION WITH DACH1 AND SIX1;MUTAGENESIS OF ASP-246
9.

Li X. , Oghi K.A. , Zhang J. , Krones A. , Bush K.T. , Glass C.K. , Nigam S.K. , Aggarwal A.K. , Maas R. , Rose D.W. , Rosenfeld M.G.
Nature427:265-265(2004)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
10.

"Eyes absent represents a class of protein tyrosine phosphatases."
Rayapureddi J.P. , Kattamuri C. , Steinmetz B.D. , Frankfort B.J. , Ostrin E.J. , Mardon G. , Hegde R.S.
Nature426:295-298(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;SUBCELLULAR LOCATION;MUTAGENESIS OF ASP-246; ASP-248; THR-250; THR-419; GLY-473; ASP-474 AND GLU-478
11.

"The transcription factor Eyes absent is a protein tyrosine phosphatase."
Tootle T.L. , Silver S.J. , Davies E.L. , Newman V. , Latek R.R. , Mills I.A. , Selengut J.D. , Parlikar B.E. , Rebay I.
Nature426:299-302(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CATALYTIC ACTIVITY;MUTAGENESIS OF ASP-246; THR-420; LYS-449; ASP-474 AND GLU-478
12.

"Large-scale phosphorylation analysis of mouse liver."
Villen J. , Beausoleil S.A. , Gerber S.A. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.104:1488-1493(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Liver.

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