F13A1 ELISA Kit for Human(Homo sapiens) | EIAab.comF13A1 ELISA Kit for Human(Homo sapiens)

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F13A1 (Gene name),

Coagulation factor XIII A chain (Protein name ), F13A_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

F13A1(F13A);

Protein name:

Coagulation factor XIII A chain(Coagulation factor XIIIa);

Alternative:

Transglutaminase A chain;Protein-glutamine gamma-glutamyltransferase A chain;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Tetramer of two A chains and two B chains.

Function:

Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin.

Subcellular Location:

Cytoplasm Secreted Secreted into the blood plasma. Cytoplasmic in most tissues, but also secreted in the blood plasma.

Protein Attributes:

Sequence length:

732

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

732:

SGHRKLIASM | SSDSLRHVYG | ELDVQIQRRP | SM

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

134570

KEGG:

hsa:2162

STRING:

9606.ENSP00000264870

UniGene:

Hs.335513

String:

P00488

Pfam:

PF00927

SMR:

P00488

Uniprot:

P00488

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ELISA Kit for Human Coagulation factor XIIIa

Cat.:

E0676h

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96T

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ELISA Kit for Human Coagulation factor XIIIa

MSDS:

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ELISA Kit for Human Coagulation factor XIIIa

Cat.:

E0676m

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Looking for manual.

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96T

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ELISA Kit for Human Coagulation factor XIIIa

Cat.:

E0676r

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Packing:

96T

CLIA Kit for Human Coagulation factor XIIIa

Cat.:

U0676r

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Packing:

96T

CLIA Kit for Human Coagulation factor XIIIa

MSDS:

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CLIA Kit for Human Coagulation factor XIIIa

Cat.:

U0676m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Coagulation factor XIIIa

Cat.:

U0676h

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96T

Polyclonal Antibody for Human Coagulation factor XIIIa

Cat.:

P0676Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Coagulation factor XIIIa

Cat.:

P0676Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Coagulation factor XIIIa

Cat.:

P0676Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Coagulation factor XIIIa

Protein for Human Coagulation factor XIIIa

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Amino acid sequence of the a subunit of human factor XIII."
Ichinose A. , Hendrickson L.E. , Fujikawa K. , Davie E.W.
Biochemistry25:6900-6906(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT ILE-651
2.

"Characterization of cDNA coding for human factor XIIIa."
Grundmann U. , Amann E. , Zettlmeissl G. , Kuepper H.A.
Proc. Natl. Acad. Sci. U.S.A.83:8024-8028(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Characterization of the gene for the a subunit of human factor XIII (plasma transglutaminase), a blood coagulation factor."
Ichinose A. , Davie E.W.
Proc. Natl. Acad. Sci. U.S.A.85:5829-5833(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT LEU-565
4.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT GLU-652
tissue: Brain.
5.

SeattleSNPs variation discovery resource
Submitted (2001-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-35; ILE-40; PHE-205; LEU-565; ILE-651 AND GLU-652
6.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT GLU-652
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS ILE-650 AND GLU-652
tissue: Pancreas.
8.

"Primary structure of blood coagulation factor XIIIa (fibrinoligase, transglutaminase) from human placenta."
Takahashi N. , Takahashi Y. , Putnam F.W.
Proc. Natl. Acad. Sci. U.S.A.83:8019-8023(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-731;CLEAVAGE OF INITIATOR METHIONINE;ACETYLATION AT SER-2
9.

"Amino acid sequence studies on factor XIII and the peptide released during its activation by thrombin."
Takagi T. , Doolittle R.F.
Biochemistry13:750-756(1974) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-44
10.

"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T. , Qian W.-J. , Gritsenko M.A. , Camp D.G. II , Monroe M.E. , Moore R.J. , Smith R.D.
J. Proteome Res.4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-614
tissue: Plasma.
11.

"Three-dimensional structure of a transglutaminase: human blood coagulation factor XIII."
Yee V.C. , Pedersen L.C. , Trong I.L. , Bishop P.D. , Stenkamp R.E. , Teller D.C.
Proc. Natl. Acad. Sci. U.S.A.91:7296-7300(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS)
12.

"Structural evidence that the activation peptide is not released upon thrombin cleavage of factor XIII."
Yee V.C. , Pedersen L.C. , Bishop P.D. , Stenkamp R.E. , Teller D.C.
Thromb. Res.78:389-397(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
13.

"Two non-proline cis peptide bonds may be important for factor XIII function."
Weiss M.S. , Metzner H.J. , Hilgenfeld R.
FEBS Lett.423:291-296(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS)
14.

"Identification of the calcium binding site and a novel ytterbium site in blood coagulation factor XIII by X-ray crystallography."
Fox B.A. , Yee V.C. , Pedersen L.C. , le Trong I. , Bishop P.D. , Stenkamp R.E. , Teller D.C.
J. Biol. Chem.274:4917-4923(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS)
15.

"Molecular basis for subtypic differences of the 'a' subunit of coagulation factor XIII with description of the genesis of the subtypes."
Suzuki K. , Iwata M. , Ito S. , Matsui K. , Uchida A. , Mizoi Y.
Hum. Genet.94:129-135(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM
16.

"Identification of a point mutation in factor XIII A subunit deficiency."
Board P. , Coggan M. , Miloszewski K.
Blood80:937-941(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FA13AD HIS-682
17.

"The Val34Leu polymorphism in the A subunit of coagulation factor XIII contributes to the large normal range in activity and demonstrates that the activation peptide plays a role in catalytic activity."
Kangsadalampai S. , Board P.G.
Blood92:2766-2770(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT LEU-35
18.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LEU-35; ILE-551; LEU-565; GLN-589; ILE-651 AND GLU-652
19.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM

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