Gene name:
FAM175A (RCJMB04_33o10;ABRA1;CCDC98) ;
Protein name:
BRCA1-A complex subunit Abraxas ;
Alternative:
Protein FAM175A ;Coiled-coil domain-containing protein 98 ;
Organism:
Chicken (Gallus gallus).
General Annotation
Sub Unit:
Component of the BRCA1-A complex. Component of the BRISC complex. Interacts directly (when phosphorylated at Ser-402) with BRCA1.
Function:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Subcellular Location:
Nucleus
Localizes at sites of DNA damage at double-strand breaks (DSBs).
Protein Attributes:
50:
MEGESTSALL | SGFVFGALAF | QHLSTDSDTE | GFLLGDVKGE | AKNSITDSQM |
100:
DDVEVVYTID | IQKHIPCYQL | FSFYNSAGEL | NEPALKKILS | GRKKSVIGWY |
150:
KFRRNTDQIM | TFRERLLHKN | LQSHLSNQGL | VFLLLTSSVM | TESCSTYRLE |
200:
HALHRPQEGL | FQKVPLVVTN | LGMAEQQGYR | TVSGSCASSG | FVRAVKQHRS |
250:
EFFYEDGSLQ | EVHKINEMYA | TLQEELKKMC | SDVEVSERSV | EKLLTEVSQL |
300:
KEEINRKKQH | KISSGGNKDQ | LEEPKENVLL | CQALRTFFPS | SDLQTCIVSF |
350:
KGRISKNCCK | IDHNINIMDK | LTLMVEERDF | TEAETKLVTK | RKVRVTTTGP |
400:
KSLKKLRSLQ | LDQELHQDEE | DCNQETKLAL | SSAETDEEAL | ENPKDTNEYS |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Chicken
Human
ELISA Kit for Chicken BRCA1-A complex subunit Abraxas
ELISA Kit for Chicken BRCA1-A complex subunit Abraxas
ELISA Kit for Chicken BRCA1-A complex subunit Abraxas
ELISA Kit for Chicken BRCA1-A complex subunit Abraxas
ELISA Kit for Chicken BRCA1-A complex subunit Abraxas
CLIA Kit for Chicken BRCA1-A complex subunit Abraxas
CLIA Kit for Chicken BRCA1-A complex subunit Abraxas
CLIA Kit for Chicken BRCA1-A complex subunit Abraxas
CLIA Kit for Chicken BRCA1-A complex subunit Abraxas
CLIA Kit for Chicken BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Chicken BRCA1-A complex subunit Abraxas
Protein for Chicken BRCA1-A complex subunit Abraxas
Protein for Chicken BRCA1-A complex subunit Abraxas
Protein for Chicken BRCA1-A complex subunit Abraxas
Protein for Chicken BRCA1-A complex subunit Abraxas
Protein for Chicken BRCA1-A complex subunit Abraxas
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"Full-length cDNAs from chicken bursal lymphocytes to facilitate gene function analysis."
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Genome Biol.6:R6.1-R6.9(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain :
CB .
tissue :
Bursa of Fabricius .
2.
"Sequence and comparative analysis of the chicken genome provide unique perspectives on vertebrate evolution."
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more...
Nature432:695-716(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Red jungle fowl .