Gene name:
FAM175A (UNQ496/PRO1013;ABRA1;CCDC98) ;
Protein name:
BRCA1-A complex subunit Abraxas ;
Alternative:
Protein FAM175A ;Coiled-coil domain-containing protein 98 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin.
Function:
Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
Subcellular Location:
Nucleus
Localizes at sites of DNA damage at double-strand breaks.
Protein Attributes:
50:
MEGESTSAVL | SGFVLGALAF | QHLNTDSDTE | GFLLGEVKGE | AKNSITDSQM |
100:
DDVEVVYTID | IQKYIPCYQL | FSFYNSSGEV | NEQALKKILS | NVKKNVVGWY |
150:
KFRRHSDQIM | TFRERLLHKN | LQEHFSNQDL | VFLLLTPSII | TESCSTHRLE |
200:
HSLYKPQKGL | FHRVPLVVAN | LGMSEQLGYK | TVSGSCMSTG | FSRAVQTHSS |
250:
KFFEEDGSLK | EVHKINEMYA | SLQEELKSIC | KKVEDSEQAV | DKLVKDVNRL |
300:
KREIEKRRGA | QIQAAREKNI | QKDPQENIFL | CQALRTFFPN | SEFLHSCVMS |
350:
LKNRHVSKSS | CNYNHHLDVV | DNLTLMVEHT | DIPEASPAST | PQIIKHKALD |
400:
LDDRWQFKRS | RLLDTQDKRS | KADTGSSNQD | KASKMSSPET | DEEIEKMKGF |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Bovine
Rat
Mouse
Chicken
Human
ELISA Kit for Human BRCA1-A complex subunit Abraxas
ELISA Kit for Human BRCA1-A complex subunit Abraxas
ELISA Kit for Human BRCA1-A complex subunit Abraxas
ELISA Kit for Human BRCA1-A complex subunit Abraxas
ELISA Kit for Human BRCA1-A complex subunit Abraxas
CLIA Kit for Human BRCA1-A complex subunit Abraxas
CLIA Kit for Human BRCA1-A complex subunit Abraxas
CLIA Kit for Human BRCA1-A complex subunit Abraxas
CLIA Kit for Human BRCA1-A complex subunit Abraxas
CLIA Kit for Human BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
Protein for Human BRCA1-A complex subunit Abraxas
Protein for Human BRCA1-A complex subunit Abraxas
Protein for Human BRCA1-A complex subunit Abraxas
Protein for Human BRCA1-A complex subunit Abraxas
Protein for Human BRCA1-A complex subunit Abraxas
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1 AND UIMC1;PHOSPHORYLATION AT SER-406;MUTAGENESIS OF SER-406
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASN-373
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-409;VARIANT THR-348
tissue :
Placenta .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1 AND UIMC1;PHOSPHORYLATION AT SER-406;MUTAGENESIS OF SER-406
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1 AND UIMC1;PHOSPHORYLATION AT SER-406;MUTAGENESIS OF SER-406
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-387; THR-390 AND SER-406;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION IN THE BRCA1-A COMPLEX;DOMAIN MPN-LIKE;INTERACTION WITH UIMC1; BRCC3; BRE; BABAM1 AND BRCA1;UBIQUITIN-BINDING
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;IDENTIFICATION IN THE BRCA1-A COMPLEX;INTERACTION WITH UIMC1; BRCC3; BRE AND BRCA1
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-406;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-387; THR-390 AND SER-406;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS THR-348 AND ASN-373
18.
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[
PubMed ]
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Cited for : FUNCTION;VARIANTS THR-348 AND ASN-373;VARIANT BC GLN-361;CHARACTERIZATION OF VARIANT BC GLN-361
19.
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Cited for : CHARACTERIZATION OF VARIANT BC GLN-361