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Index > Protein center > FAM175A(Gene name) > Human
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  • FAM175A (Gene name),
  • BRCA1-A complex subunit Abraxas (Protein name ),  F175A_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    FAM175A(UNQ496/PRO1013;ABRA1;CCDC98);
    Protein name:
    BRCA1-A complex subunit Abraxas;
    Alternative:
    Protein FAM175A;Coiled-coil domain-containing protein 98;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Component of the BRCA1-A complex, at least composed of the BRCA1, BARD1, UIMC1/RAP80, FAM175A/Abraxas, BRCC3/BRCC36, BRE/BRCC45 and BABAM1/NBA1. In the complex, interacts directly with UIMC1/RAP80, BRCC3/BRCC36 and BRE/BRCC45. Interacts directly (when phosphorylated at Ser-406) with BRCA1. Binds polyubiquitin.
    Function:
    Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it acts as a central scaffold protein that assembles the various components of the BRCA1-A complex and mediates the recruitment of BRCA1.
    Subcellular Location:
    Nucleus Localizes at sites of DNA damage at double-strand breaks.
    Protein Attributes:
    Sequence length:
    409
    Sequence:
    50:
    MEGESTSAVL | SGFVLGALAF | QHLNTDSDTE | GFLLGEVKGE | AKNSITDSQM | 
    100:
    DDVEVVYTID | IQKYIPCYQL | FSFYNSSGEV | NEQALKKILS | NVKKNVVGWY | 
    150:
    KFRRHSDQIM | TFRERLLHKN | LQEHFSNQDL | VFLLLTPSII | TESCSTHRLE | 
    200:
    HSLYKPQKGL | FHRVPLVVAN | LGMSEQLGYK | TVSGSCMSTG | FSRAVQTHSS | 
    250:
    KFFEEDGSLK | EVHKINEMYA | SLQEELKSIC | KKVEDSEQAV | DKLVKDVNRL | 
    300:
    KREIEKRRGA | QIQAAREKNI | QKDPQENIFL | CQALRTFFPN | SEFLHSCVMS | 
    350:
    LKNRHVSKSS | CNYNHHLDVV | DNLTLMVEHT | DIPEASPAST | PQIIKHKALD | 
    400:
    LDDRWQFKRS | RLLDTQDKRS | KADTGSSNQD | KASKMSSPET | DEEIEKMKGF | 
    409:
    GEYSRSPTF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human BRCA1-A complex subunit Abraxas
    ELISA Kit for Human BRCA1-A complex subunit Abraxas
    ELISA Kit for Human BRCA1-A complex subunit Abraxas
    ELISA Kit for Human BRCA1-A complex subunit Abraxas
    ELISA Kit for Human BRCA1-A complex subunit Abraxas
    CLIA Kit for Human BRCA1-A complex subunit Abraxas
    CLIA Kit for Human BRCA1-A complex subunit Abraxas
    CLIA Kit for Human BRCA1-A complex subunit Abraxas
    CLIA Kit for Human BRCA1-A complex subunit Abraxas
    CLIA Kit for Human BRCA1-A complex subunit Abraxas
    Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Polyclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Monoclonal Antibody for Human BRCA1-A complex subunit Abraxas
    Protein for Human BRCA1-A complex subunit Abraxas
    Protein for Human BRCA1-A complex subunit Abraxas
    Protein for Human BRCA1-A complex subunit Abraxas
    Protein for Human BRCA1-A complex subunit Abraxas
    Protein for Human BRCA1-A complex subunit Abraxas

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    References
    1. 1.
      "Abraxas and RAP80 form a BRCA1 protein complex required for the DNA damage response."
      Wang B. , Matsuoka S. , Ballif B.A. , Zhang D. , Smogorzewska A. , Giyi S. , Elledge S.J.
      Science316:1194-1198(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1 AND UIMC1;PHOSPHORYLATION AT SER-406;MUTAGENESIS OF SER-406
    2. 2.
      "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment."
      Clark H.F. , Gurney A.L. , Abaya E. , Baker K. , Baldwin D.T. , Brush J. , Chen J. , Chow B. , Chui C. , Crowley C. , Currell B. , Deuel B. , Dowd P. , Eaton D. , Foster J.S. , Grimaldi C. , Gu Q. , Hass P.E. , more...
      Genome Res.13:2265-2270(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT ASN-373
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Testis.
    5. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 95-409;VARIANT THR-348
      tissue: Placenta.
    6. 6.
      "CCDC98 targets BRCA1 to DNA damage sites."
      Liu Z. , Wu J. , Yu X.
      Nat. Struct. Mol. Biol.14:716-720(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1 AND UIMC1;PHOSPHORYLATION AT SER-406;MUTAGENESIS OF SER-406
    7. 7.
      "CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response."
      Kim H. , Huang J. , Chen J.
      Nat. Struct. Mol. Biol.14:710-715(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1 AND UIMC1;PHOSPHORYLATION AT SER-406;MUTAGENESIS OF SER-406
    8. 8.
      "Ubc13/Rnf8 ubiquitin ligases control foci formation of the Rap80/Abraxas/Brca1/Brcc36 complex in response to DNA damage."
      Wang B. , Elledge S.J.
      Proc. Natl. Acad. Sci. U.S.A.104:20759-20763(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    9. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-387; THR-390 AND SER-406;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    10. 10.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "MERIT40 controls BRCA1-Rap80 complex integrity and recruitment to DNA double-strand breaks."
      Shao G. , Patterson-Fortin J. , Messick T.E. , Feng D. , Shanbhag N. , Wang Y. , Greenberg R.A.
      Genes Dev.23:740-754(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX
    12. 12.
      "NBA1, a new player in the Brca1 A complex, is required for DNA damage resistance and checkpoint control."
      Wang B. , Hurov K. , Hofmann K. , Elledge S.J.
      Genes Dev.23:729-739(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE BRCA1-A COMPLEX;DOMAIN MPN-LIKE;INTERACTION WITH UIMC1; BRCC3; BRE; BABAM1 AND BRCA1;UBIQUITIN-BINDING
    13. 13.
      "MERIT40 facilitates BRCA1 localization and DNA damage repair."
      Feng L. , Huang J. , Chen J.
      Genes Dev.23:719-728(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;IDENTIFICATION IN THE BRCA1-A COMPLEX;INTERACTION WITH UIMC1; BRCC3; BRE AND BRCA1
    14. 14.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-390 AND SER-406;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    15. 15.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-387; THR-390 AND SER-406;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    16. 16.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-386; SER-387 AND THR-390;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    17. 17.
      "Analysis of the genes coding for the BRCA1-interacting proteins, RAP80 and Abraxas (CCDC98), in high-risk, non-BRCA1/2, multiethnic breast cancer cases."
      Novak D.J. , Sabbaghian N. , Maillet P. , Chappuis P.O. , Foulkes W.D. , Tischkowitz M.
      Breast Cancer Res. Treat.117:453-459(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS THR-348 AND ASN-373
    18. 18.
      "Breast cancer-associated Abraxas mutation disrupts nuclear localization and DNA damage response functions."
      Solyom S. , Aressy B. , Pylkas K. , Patterson-Fortin J. , Hartikainen J.M. , Kallioniemi A. , Kauppila S. , Nikkila J. , Kosma V.M. , Mannermaa A. , Greenberg R.A. , Winqvist R.
      Sci. Transl. Med.4:122ra23-122ra23(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANTS THR-348 AND ASN-373;VARIANT BC GLN-361;CHARACTERIZATION OF VARIANT BC GLN-361
    19. 19.
      "Mislocalization of BRCA1-complex due to ABRAXAS Arg361Gln mutation."
      Kumar R.V. , Siddiqui Q. , Singh N. , Waghmare S.K. , Varma A.K.
      J. Biomol. Struct. Dyn.2014:1-11(2014) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT BC GLN-361
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