Fancd2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comFancd2 ELISA Kit for Rat(Rattus norvegicus)

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Index > Protein center > Fancd2(Gene name) > Rat

Fancd2 (Gene name),

Fanconi anemia group D2 protein homolog (Protein name ), FACD2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Fancd2;

Protein name:

Fanconi anemia group D2 protein homolog(Protein FACD2);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Interacts directly with FANCE and FANCI. Interacts with USP1 and MEN1. The ubiquitinated form specifically interacts with BRCA1 and BLM. Both the nonubiquitinated and the monoubiquitinated forms interact with BRCA2; this interaction is mediated by phosphorylated FANCG and the complex also includes XCCR3 (By similarity). The ubiquitinated form specifically interacts with MTMR15/FAN1 (via UBZ-type zinc finger), leading to recruit MTMR15/FAN1 to sites of DNA damage. Interacts with DCLRE1B/Apollo.

Function:

Required for maintenance of chromosomal stability. Promotes accurate and efficient pairing of homologs during meiosis. Involved in the repair of DNA double-strand breaks, both by homologous recombination and single-strand annealing. May participate in S phase and G2 phase checkpoint activation upon DNA damage. Plays a role in preventing breakage and loss of missegregating chromatin at the end of cell division, particularly after replication stress (By similarity). Promotes BRCA2/FANCD1 loading onto damaged chromatin. May also be involved in B-cell immunoglobulin isotype switching.

Subcellular Location:

Nucleus Concentrates in nuclear foci during S phase and upon genotoxic stress.

Protein Attributes:

Sequence length:

1451

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3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.203979

String:

Q6IV68

KEGG:

rno:312641

STRING:

10116.ENSRNOP00000033638

Uniprot:

Q6IV68

FOR

ELISA Kit for Rat Protein FACD2

CLIA Kit for Rat Protein FACD2

Polyclonal Antibody for Rat Protein FACD2

Monoclonal Antibody for Rat Protein FACD2

Protein for Rat Protein FACD2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Strain specific allelic variations in the rat FanCD2 coding sequence."
Rosemann M.F. , Ivashkevich A. , Lichtmannegger J.
Submitted (2004-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Wistar Kyoto.
tissue: Liver.

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