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Index > Protein center > FAIM3(Gene name) > Human
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  • FAIM3 (Gene name),
  • Fas apoptotic inhibitory molecule 3 (Protein name ),  FAIM3_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    FAIM3(TOSO);
    Protein name:
    Fas apoptotic inhibitory molecule 3;
    Alternative:
    Regulator of Fas-induced apoptosis Toso;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.
    Subcellular Location:
    Membrane Single-pass membrane protein
    Protein Attributes:
    Sequence length:
    390
    Sequence:
    50:
    MDFWLWPLYF | LPVSGALRIL | PEVKVEGELG | GSVTIKCPLP | EMHVRIYLCR | 
    100:
    EMAGSGTCGT | VVSTTNFIKA | EYKGRVTLKQ | YPRKNLFLVE | VTQLTESDSG | 
    150:
    VYACGAGMNT | DRGKTQKVTL | NVHSEYEPSW | EEQPMPETPK | WFHLPYLFQM | 
    200:
    PAYASSSKFV | TRVTTPAQRG | KVPPVHHSSP | TTQITHRPRV | SRASSVAGDK | 
    250:
    PRTFLPSTTA | SKISALEGLL | KPQTPSYNHH | TRLHRQRALD | YGSQSGREGQ | 
    300:
    GFHILIPTIL | GLFLLALLGL | VVKRAVERRK | ALSRRARRLA | VRMRALESSQ | 
    350:
    RPRGSPRPRS | QNNIYSACPR | RARGADAAGT | GEAPVPGPGA | PLPPAPLQVS | 
    390:
    ESPWLHAPSL | KTSCEYVSLY | HQPAAMMEDS | DSDDYINVPA | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    UniGene:
    String:
    KEGG:
    SMR:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Fas apoptotic inhibitory molecule 3
    ELISA Kit for Human Fas apoptotic inhibitory molecule 3
    ELISA Kit for Human Fas apoptotic inhibitory molecule 3
    CLIA Kit for Human Fas apoptotic inhibitory molecule 3
    CLIA Kit for Human Fas apoptotic inhibitory molecule 3
    CLIA Kit for Human Fas apoptotic inhibitory molecule 3
    Polyclonal Antibody for Human Fas apoptotic inhibitory molecule 3
    Polyclonal Antibody for Human Fas apoptotic inhibitory molecule 3
    Polyclonal Antibody for Human Fas apoptotic inhibitory molecule 3
    Monoclonal Antibody for Human Fas apoptotic inhibitory molecule 3
    Monoclonal Antibody for Human Fas apoptotic inhibitory molecule 3
    Monoclonal Antibody for Human Fas apoptotic inhibitory molecule 3
    Protein for Human Fas apoptotic inhibitory molecule 3
    Protein for Human Fas apoptotic inhibitory molecule 3
    Protein for Human Fas apoptotic inhibitory molecule 3

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells."
      Hitoshi Y. , Lorens J. , Kitada S. , Fisher J. , LaBarge M. , Ring H.Z. , Francke U. , Reed J.C. , Kinoshita S. , Nolan G.P.
      Immunity8:461-471(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY;INDUCTION
    2. 2.
      "Enhanced levels of both the membrane-bound and soluble forms of IgM Fc receptor (Fc?R) in patients with chronic lymphocytic leukemia."
      Li F.J. , Kubagawa Y. , McCollum M.K. , Wilson L. , Motohashi T. , Bertoli L.F. , Barton J.C. , Barnes S. , Davis R.S. , Kubagawa H.
      Blood118:4902-4909(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);IDENTIFICATION BY MASS SPECTROMETRY;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Spleen.
    5. 5.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: B-cell.
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