Gene name:
FANCI (KIAA1794) ;
Protein name:
Fanconi anemia group I protein (Protein FACI) ;
Alternative:
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts directly with FANCD2. Interacts with MTMR15/FAN1.
Function:
Required for maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination and in the repair of DNA cross-links. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Promotes FANCD2 ubiquitination and recruitment to DNA repair sites.
Subcellular Location:
Nucleus
Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
Protein Attributes:
50:
MDQKILSLAA | EKTADKLQEF | LQTLREGDLT | NLLQNQAVKG | KVAGALLRAI |
100:
FKGSPCSEEA | GTLRRRKIYT | CCIQLVESGD | LQKEIASEII | GLLMLEAHHF |
150:
PGPLLVELAN | EFISAVREGS | LVNGKSLELL | PIILTALATK | KENLAYGKGV |
200:
LSGEECKKQL | INTLCSGRWD | QQYVIQLTSM | FKDVPLTAEE | VEFVVEKALS |
250:
MFSKMNLQEI | PPLVYQLLVL | SSKGSRKSVL | EGIIAFFSAL | DKQHNEEQSG |
300:
DELLDVVTVP | SGELRHVEGT | IILHIVFAIK | LDYELGRELV | KHLKVGQQGD |
350:
SNNNLSPFSI | ALLLSVTRIQ | RFQDQVLDLL | KTSVVKSFKD | LQLLQGSKFL |
400:
QNLVPHRSYV | STMILEVVKN | SVHSWDHVTQ | GLVELGFILM | DSYGPKKVLD |
450:
GKTIETSPSL | SRMPNQHACK | LGANILLETF | KIHEMIRQEI | LEQVLNRVVT |
500:
RASSPISHFL | DLLSNIVMYA | PLVLQSCSSK | VTEAFDYLSF | LPLQTVQRLL |
550:
KAVQPLLKVS | MSMRDCLILV | LRKAMFANQL | DARKSAVAGF | LLLLKNFKVL |
600:
GSLSSSQCSQ | SLSVSQVHVD | VHSHYNSVAN | ETFCLEIMDS | LRRCLSQQAD |
650:
VRLMLYEGFY | DVLRRNSQLA | NSVMQTLLSQ | LKQFYEPKPD | LLPPLKLEAC |
700:
ILTQGDKISL | QEPLDYLLCC | IQHCLAWYKN | TVIPLQQGEE | EEEEEEAFYE |
750:
DLDDILESIT | NRMIKSELED | FELDKSADFS | QSTSIGIKNN | ICAFLVMGVC |
800:
EVLIEYNFSI | SSFSKNRFED | ILSLFMCYKK | LSDILNEKAG | KAKTKMANKT |
850:
SDSLLSMKFV | SSLLTALFRD | SIQSHQESLS | VLRSSNEFMR | YAVNVALQKV |
900:
QQLKETGHVS | GPDGQNPEKI | FQNLCDITRV | LLWRYTSIPT | SVEESGKKEK |
950:
GKSISLLCLE | GLQKIFSAVQ | QFYQPKIQQF | LRALDVTDKE | GEEREDADVS |
1000:
VTQRTAFQIR | QFQRSLLNLL | SSQEEDFNSK | EALLLVTVLT | SLSKLLEPSS |
1050:
PQFVQMLSWT | SKICKENSRE | DALFCKSLMN | LLFSLHVSYK | SPVILLRDLS |
1100:
QDIHGHLGDI | DQDVEVEKTN | HFAIVNLRTA | APTVCLLVLS | QAEKVLEEVD |
1150:
WLITKLKGQV | SQETLSEEAS | SQATLPNQPV | EKAIIMQLGT | LLTFFHELVQ |
1200:
TALPSGSCVD | TLLKDLCKMY | TTLTALVRYY | LQVCQSSGGI | PKNMEKLVKL |
1250:
SGSHLTPLCY | SFISYVQNKS | KSLNYTGEKK | EKPAAVATAM | ARVLRETKPI |
1300:
PNLIFAIEQY | EKFLIHLSKK | SKVNLMQHMK | LSTSRDFKIK | GNILDMVLRE |
1328:
DGEDENEEGT | ASEHGGQNKE | PAKKKRKK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Human Protein FACI
ELISA Kit for Human Protein FACI
CLIA Kit for Human Protein FACI
CLIA Kit for Human Protein FACI
Polyclonal Antibody for Human Protein FACI
Polyclonal Antibody for Human Protein FACI
Monoclonal Antibody for Human Protein FACI
Monoclonal Antibody for Human Protein FACI
Protein for Human Protein FACI
Protein for Human Protein FACI
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;UBIQUITINATION AT LYS-523;PHOSPHORYLATION AT SER-730; THR-952 AND SER-1121;SUBCELLULAR LOCATION;INTERACTION WITH FANCD2;VARIANTS FA LEU-55 AND GLN-1285;CHARACTERIZATION OF VARIANTS FA LEU-55 AND GLN-1285
2.
"FANCI is a second monoubiquitinated member of the Fanconi anemia pathway."
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Sims R.J. III
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Arita A.G.
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Nat. Struct. Mol. Biol.14:564-567(2007)
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PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;UBIQUITINATION AT LYS-523;SUBCELLULAR LOCATION;INTERACTION WITH FANCD2;VARIANT FA TYR-858
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"Analysis of the DNA sequence and duplication history of human chromosome 15."
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Nature440:671-675(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);VARIANT VAL-86
tissue :
Brain .
tissue :
Skin .
5.
"Complete sequencing and characterization of 21,243 full-length human cDNAs."
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-1324 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 342-1328 (ISOFORM 1);VARIANT SER-742
tissue :
Teratocarcinoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 527-1328 (ISOFORM 3);VARIANT SER-742
tissue :
Brain .
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 438-447; 781-788; 809-819; 885-897; 965-994 AND 1079-1094;IDENTIFICATION BY MASS SPECTROMETRY
tissue :
B-cell lymphoma .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
9.
"Identification of the Fanconi anemia complementation group I gene, FANCI."
Dorsman J.C.
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Levitus M.
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Rockx D.
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Rooimans M.A.
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Oostra A.B.
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Cell. Oncol.29:211-218(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;VARIANT FANCI GLN-1285;VARIANT LEU-55
10.
"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
Matsuoka S.
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Ballif B.A.
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Science316:1160-1166(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Embryonic kidney .
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DNA-BINDING;UBIQUITINATION AT LYS-523;MUTAGENESIS OF LYS-523
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUBCELLULAR LOCATION
16.
"Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2."
MacKay C.
,
Declais A.C.
,
Lundin C.
,
Agostinho A.
,
Deans A.J.
,
MacArtney T.J.
,
Hofmann K.
,
Gartner A.
,
West S.C.
,
Helleday T.
,
Lilley D.M.
,
Rouse J.
Cell142:65-76(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH MTMR15
17.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FANCL