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Index > Protein center > FANCI(Gene name) > Human
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  • FANCI (Gene name),
  • Fanconi anemia group I protein (Protein name ),  FANCI_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    FANCI(KIAA1794);
    Protein name:
    Fanconi anemia group I protein(Protein FACI);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts directly with FANCD2. Interacts with MTMR15/FAN1.
    Function:
    Required for maintenance of chromosomal stability. Involved in the repair of DNA double-strand breaks by homologous recombination and in the repair of DNA cross-links. Participates in S phase and G2 phase checkpoint activation upon DNA damage. Promotes FANCD2 ubiquitination and recruitment to DNA repair sites.
    Subcellular Location:
    Nucleus Observed in spots localized in pairs on the sister chromatids of mitotic chromosome arms and not centromeres, one on each chromatids. These foci coincide with common fragile sites. They are frequently interlinked through BLM-associated ultra-fine DNA bridges.
    Protein Attributes:
    Sequence length:
    1328
    Sequence:
    50:
    MDQKILSLAA | EKTADKLQEF | LQTLREGDLT | NLLQNQAVKG | KVAGALLRAI | 
    100:
    FKGSPCSEEA | GTLRRRKIYT | CCIQLVESGD | LQKEIASEII | GLLMLEAHHF | 
    150:
    PGPLLVELAN | EFISAVREGS | LVNGKSLELL | PIILTALATK | KENLAYGKGV | 
    200:
    LSGEECKKQL | INTLCSGRWD | QQYVIQLTSM | FKDVPLTAEE | VEFVVEKALS | 
    250:
    MFSKMNLQEI | PPLVYQLLVL | SSKGSRKSVL | EGIIAFFSAL | DKQHNEEQSG | 
    300:
    DELLDVVTVP | SGELRHVEGT | IILHIVFAIK | LDYELGRELV | KHLKVGQQGD | 
    350:
    SNNNLSPFSI | ALLLSVTRIQ | RFQDQVLDLL | KTSVVKSFKD | LQLLQGSKFL | 
    400:
    QNLVPHRSYV | STMILEVVKN | SVHSWDHVTQ | GLVELGFILM | DSYGPKKVLD | 
    450:
    GKTIETSPSL | SRMPNQHACK | LGANILLETF | KIHEMIRQEI | LEQVLNRVVT | 
    500:
    RASSPISHFL | DLLSNIVMYA | PLVLQSCSSK | VTEAFDYLSF | LPLQTVQRLL | 
    550:
    KAVQPLLKVS | MSMRDCLILV | LRKAMFANQL | DARKSAVAGF | LLLLKNFKVL | 
    600:
    GSLSSSQCSQ | SLSVSQVHVD | VHSHYNSVAN | ETFCLEIMDS | LRRCLSQQAD | 
    650:
    VRLMLYEGFY | DVLRRNSQLA | NSVMQTLLSQ | LKQFYEPKPD | LLPPLKLEAC | 
    700:
    ILTQGDKISL | QEPLDYLLCC | IQHCLAWYKN | TVIPLQQGEE | EEEEEEAFYE | 
    750:
    DLDDILESIT | NRMIKSELED | FELDKSADFS | QSTSIGIKNN | ICAFLVMGVC | 
    800:
    EVLIEYNFSI | SSFSKNRFED | ILSLFMCYKK | LSDILNEKAG | KAKTKMANKT | 
    850:
    SDSLLSMKFV | SSLLTALFRD | SIQSHQESLS | VLRSSNEFMR | YAVNVALQKV | 
    900:
    QQLKETGHVS | GPDGQNPEKI | FQNLCDITRV | LLWRYTSIPT | SVEESGKKEK | 
    950:
    GKSISLLCLE | GLQKIFSAVQ | QFYQPKIQQF | LRALDVTDKE | GEEREDADVS | 
    1000:
    VTQRTAFQIR | QFQRSLLNLL | SSQEEDFNSK | EALLLVTVLT | SLSKLLEPSS | 
    1050:
    PQFVQMLSWT | SKICKENSRE | DALFCKSLMN | LLFSLHVSYK | SPVILLRDLS | 
    1100:
    QDIHGHLGDI | DQDVEVEKTN | HFAIVNLRTA | APTVCLLVLS | QAEKVLEEVD | 
    1150:
    WLITKLKGQV | SQETLSEEAS | SQATLPNQPV | EKAIIMQLGT | LLTFFHELVQ | 
    1200:
    TALPSGSCVD | TLLKDLCKMY | TTLTALVRYY | LQVCQSSGGI | PKNMEKLVKL | 
    1250:
    SGSHLTPLCY | SFISYVQNKS | KSLNYTGEKK | EKPAAVATAM | ARVLRETKPI | 
    1300:
    PNLIFAIEQY | EKFLIHLSKK | SKVNLMQHMK | LSTSRDFKIK | GNILDMVLRE | 
    1328:
    DGEDENEEGT | ASEHGGQNKE | PAKKKRKK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    MIM:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein FACI
    ELISA Kit for Human Protein FACI
    CLIA Kit for Human Protein FACI
    CLIA Kit for Human Protein FACI
    Polyclonal Antibody for Human Protein FACI
    Polyclonal Antibody for Human Protein FACI
    Monoclonal Antibody for Human Protein FACI
    Monoclonal Antibody for Human Protein FACI
    Protein for Human Protein FACI
    Protein for Human Protein FACI

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Identification of the FANCI protein, a monoubiquitinated FANCD2 paralog required for DNA repair."
      Smogorzewska A. , Matsuoka S. , Vinciguerra P. , McDonald E.R. III , Hurov K.E. , Luo J. , Ballif B.A. , Gygi S.P. , Hofmann K. , D'Andrea A.D. , Elledge S.J.
      Cell129:289-301(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;UBIQUITINATION AT LYS-523;PHOSPHORYLATION AT SER-730; THR-952 AND SER-1121;SUBCELLULAR LOCATION;INTERACTION WITH FANCD2;VARIANTS FA LEU-55 AND GLN-1285;CHARACTERIZATION OF VARIANTS FA LEU-55 AND GLN-1285
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);FUNCTION;UBIQUITINATION AT LYS-523;SUBCELLULAR LOCATION;INTERACTION WITH FANCD2;VARIANT FA TYR-858
    3. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 3 AND 4);VARIANT VAL-86
      tissue: Brain.
      tissue: Skin.
    4. 5.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 175-1324 (ISOFORM 2);NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 342-1328 (ISOFORM 1);VARIANT SER-742
      tissue: Teratocarcinoma.
    5. 6.
      "Prediction of the coding sequences of unidentified human genes. XX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro."
      Nagase T. , Nakayama M. , Nakajima D. , Kikuno R. , Ohara O.
      DNA Res.8:85-95(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 527-1328 (ISOFORM 3);VARIANT SER-742
      tissue: Brain.
    6. 7.
      Bienvenut W.V.
      Submitted (2005-06) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 438-447; 781-788; 809-819; 885-897; 965-994 AND 1079-1094;IDENTIFICATION BY MASS SPECTROMETRY
      tissue: B-cell lymphoma.
    7. 8.
      "A probability-based approach for high-throughput protein phosphorylation analysis and site localization."
      Beausoleil S.A. , Villen J. , Gerber S.A. , Rush J. , Gygi S.P.
      Nat. Biotechnol.24:1285-1292(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANT FANCI GLN-1285;VARIANT LEU-55
    9. 10.
      "ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage."
      Matsuoka S. , Ballif B.A. , Smogorzewska A. , McDonald E.R. III , Hurov K.E. , Luo J. , Bakalarski C.E. , Zhao Z. , Solimini N. , Lerenthal Y. , Shiloh Y. , Gygi S.P. , Elledge S.J.
      Science316:1160-1166(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Embryonic kidney.
    10. 11.
      "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H. , Olsen J.V. , Bairlein M. , Gnad F. , Oppermann F.S. , Korner R. , Greff Z. , Keri G. , Stemmann O. , Mann M.
      Mol. Cell31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI."
      Alpi A.F. , Pace P.E. , Babu M.M. , Patel K.J.
      Mol. Cell32:767-777(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    12. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-407;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    13. 14.
      "FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL."
      Longerich S. , San Filippo J. , Liu D. , Sung P.
      J. Biol. Chem.284:23182-23186(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DNA-BINDING;UBIQUITINATION AT LYS-523;MUTAGENESIS OF LYS-523
    14. 15.
      "Replication stress induces sister-chromatid bridging at fragile site loci in mitosis."
      Chan K.L. , Palmai-Pallag T. , Ying S. , Hickson I.D.
      Nat. Cell Biol.11:753-760(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    15. 16.
      "Identification of KIAA1018/FAN1, a DNA repair nuclease recruited to DNA damage by monoubiquitinated FANCD2."
      MacKay C. , Declais A.C. , Lundin C. , Agostinho A. , Deans A.J. , MacArtney T.J. , Hofmann K. , Gartner A. , West S.C. , Helleday T. , Lilley D.M. , Rouse J.
      Cell142:65-76(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MTMR15
    16. 17.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    17. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    18. 19.
      "Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway."
      Hodson C. , Cole A.R. , Lewis L.P. , Miles J.A. , Purkiss A. , Walden H.
      J. Biol. Chem.286:32628-32637(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FANCL
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