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Index > Protein center > BRIP1(Gene name) > Human
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  • BRIP1 (Gene name),
  • Fanconi anemia group J protein (Protein name ),  FANCJ_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    BRIP1(BACH1;FANCJ);
    Protein name:
    Fanconi anemia group J protein(Protein FACJ);
    Alternative:
    BRCA1-associated C-terminal helicase 1;ATP-dependent RNA helicase BRIP1;BRCA1-interacting protein C-terminal helicase 1(BRCA1-interacting protein 1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Binds directly to the BRCT domains of BRCA1.
    Function:
    DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
    Subcellular Location:
    Nucleus
    Protein Attributes:
    Sequence length:
    1249
    Sequence:
    50:
    MSSMWSEYTI | GGVKIYFPYK | AYPSQLAMMN | SILRGLNSKQ | HCLLESPTGS | 
    100:
    GKSLALLCSA | LAWQQSLSGK | PADEGVSEKA | EVQLSCCCAC | HSKDFTNNDM | 
    150:
    NQGTSRHFNY | PSTPPSERNG | TSSTCQDSPE | KTTLAAKLSA | KKQASIYRDE | 
    200:
    NDDFQVEKKR | IRPLETTQQI | RKRHCFGTEV | HNLDAKVDSG | KTVKLNSPLE | 
    250:
    KINSFSPQKP | PGHCSRCCCS | TKQGNSQESS | NTIKKDHTGK | SKIPKIYFGT | 
    300:
    RTHKQIAQIT | RELRRTAYSG | VPMTILSSRD | HTCVHPEVVG | NFNRNEKCME | 
    350:
    LLDGKNGKSC | YFYHGVHKIS | DQHTLQTFQG | MCKAWDIEEL | VSLGKKLKAC | 
    400:
    PYYTARELIQ | DADIIFCPYN | YLLDAQIRES | MDLNLKEQVV | ILDEAHNIED | 
    450:
    CARESASYSV | TEVQLRFARD | ELDSMVNNNI | RKKDHEPLRA | VCCSLINWLE | 
    500:
    ANAEYLVERD | YESACKIWSG | NEMLLTLHKM | GITTATFPIL | QGHFSAVLQK | 
    550:
    EEKISPIYGK | EEAREVPVIS | ASTQIMLKGL | FMVLDYLFRQ | NSRFADDYKI | 
    600:
    AIQQTYSWTN | QIDISDKNGL | LVLPKNKKRS | RQKTAVHVLN | FWCLNPAVAF | 
    650:
    SDINGKVQTI | VLTSGTLSPM | KSFSSELGVT | FTIQLEANHI | IKNSQVWVGT | 
    700:
    IGSGPKGRNL | CATFQNTETF | EFQDEVGALL | LSVCQTVSQG | ILCFLPSYKL | 
    750:
    LEKLKERWLS | TGLWHNLELV | KTVIVEPQGG | EKTNFDELLQ | VYYDAIKYKG | 
    800:
    EKDGALLVAV | CRGKVSEGLD | FSDDNARAVI | TIGIPFPNVK | DLQVELKRQY | 
    850:
    NDHHSKLRGL | LPGRQWYEIQ | AYRALNQALG | RCIRHRNDWG | ALILVDDRFR | 
    900:
    NNPSRYISGL | SKWVRQQIQH | HSTFESALES | LAEFSKKHQK | VLNVSIKDRT | 
    950:
    NIQDNESTLE | VTSLKYSTPP | YLLEAASHLS | PENFVEDEAK | ICVQELQCPK | 
    1000:
    IITKNSPLPS | SIISRKEKND | PVFLEEAGKA | EKIVISRSTS | PTFNKQTKRV | 
    1050:
    SWSSFNSLGQ | YFTGKIPKAT | PELGSSENSA | SSPPRFKTEK | MESKTVLPFT | 
    1100:
    DKCESSNLTV | NTSFGSCPQS | ETIISSLKID | ATLTRKNHSE | HPLCSEEALD | 
    1150:
    PDIELSLVSE | EDKQSTSNRD | FETEAEDESI | YFTPELYDPE | DTDEEKNDLA | 
    1200:
    ETDRGNRLAN | NSDCILAKDL | FEIRTIKEVD | SAREVKAEDC | IDTKLNGILH | 
    1249:
    IEESKIDDID | GNVKTTWINE | LELGKTHEIE | IKNFKPSPSK | NKGMFPGFK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    Pfam:
    KEGG:
    MIM:
    SMR:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Protein FACJ
    ELISA Kit for Human Protein FACJ
    ELISA Kit for Human Protein FACJ
    CLIA Kit for Human Protein FACJ
    CLIA Kit for Human Protein FACJ
    CLIA Kit for Human Protein FACJ
    Polyclonal Antibody for Human Protein FACJ
    Polyclonal Antibody for Human Protein FACJ
    Polyclonal Antibody for Human Protein FACJ
    Monoclonal Antibody for Human Protein FACJ
    Monoclonal Antibody for Human Protein FACJ
    Monoclonal Antibody for Human Protein FACJ
    Protein for Human Protein FACJ
    Protein for Human Protein FACJ
    Protein for Human Protein FACJ

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function."
      Cantor S.B. , Bell D.W. , Ganesan S. , Kass E.M. , Drapkin R. , Grossman S. , Wahrer D.C.R. , Sgroi D.C. , Lane W.S. , Haber D.A. , Livingston D.M.
      Cell105:149-160(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 708-747; 765-790; 815-831; 1079-1085; 1169-1174 AND 1215-1225;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1;MUTAGENESIS OF LYS-52;VARIANTS BC ALA-47 AND ILE-299;VARIANTS ILE-193 AND SER-919;IDENTIFICATION BY MASS SPECTROMETRY
    2. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    3. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-1249 (ISOFORM 2);VARIANT SER-919
    4. 5.
      "The BRCT domain is a phospho-protein binding domain."
      Yu X. , Chini C.C.S. , He M. , Mer G. , Chen J.
      Science302:639-642(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-990;MUTAGENESIS OF SER-986; SER-988; THR-989; SER-990; PRO-991; THR-992; PHE-993; THR-997; SER-1001; SER-1003; SER-1004; SER-1007; TYR-1011 AND THR-1013
    5. 6.
      "The BRCA1-associated protein BACH1 is a DNA helicase targeted by clinically relevant inactivating mutations."
      Cantor S.B. , Drapkin R. , Zhang F. , Lin Y. , Han J. , Pamidi S. , Livingston D.M.
      Proc. Natl. Acad. Sci. U.S.A.101:2357-2362(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-52;CHARACTERIZATION OF VARIANTS BC ALA-47 AND ILE-299
    6. 7.
      "BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ."
      Litman R. , Peng M. , Jin Z. , Zhang F. , Zhang J. , Powell S. , Andreassen P.R. , Cantor S.B.
      Cancer Cell8:255-265(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;VARIANT SER-919;DISEASE
    7. 8.
      "The BRIP1 helicase functions independently of BRCA1 in the Fanconi anemia pathway for DNA crosslink repair."
      Bridge W.L. , Vandenberg C.J. , Franklin R.J. , Hiom K.
      Nat. Genet.37:953-957(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LYS-52;DISEASE
    8. 9.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927; SER-930 AND SER-990;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 10.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930 AND SER-1032;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1237;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    11. 12.
      "FANCJ/BACH1 acetylation at lysine 1249 regulates the DNA damage response."
      Xie J. , Peng M. , Guillemette S. , Quan S. , Maniatis S. , Wu Y. , Venkatesh A. , Shaffer S.A. , Brosh R.M. Jr. , Cantor S.B.
      PLoS Genet.8:E1002786-E1002786(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION AT LYS-1249
    12. 13.
      "Structure of the BRCT repeats of BRCA1 bound to a BACH1 phosphopeptide: implications for signaling."
      Shiozaki E.N. , Gu L. , Yan N. , Shi Y.
      Mol. Cell14:405-412(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 985-998 IN COMPLEX WITH BRCA1;SUBUNIT
    13. 14.
      "No mutations in the BACH1 gene in BRCA1 and BRCA2 negative breast-cancer families linked to 17q22."
      Luo L. , Lei H. , Du Q. , von Wachenfeldt A. , Kockum I. , Luthman H. , Vorechovsky I. , Lindblom A.
      Int. J. Cancer98:638-639(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-173 AND SER-919
    14. 15.
      "No evidence of involvement of germline BACH1 mutations in Finnish breast and ovarian cancer families."
      Karppinen S.-M. , Vuosku J. , Heikkinen K. , Allinen M. , Winqvist R.
      Eur. J. Cancer39:366-371(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS SER-919 AND LEU-1034
    15. 16.
      "Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."
      Rutter J.L. , Smith A.M. , Davila M.R. , Sigurdson A.J. , Giusti R.M. , Pineda M.A. , Doody M.M. , Tucker M.A. , Greene M.H. , Zhang J. , Struewing J.P.
      Hum. Mutat.22:121-128(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS CYS-173; ILE-193; PRO-195; TRP-419; VAL-531; LEU-540; TYR-832; SER-919 AND GLY-935
    16. 17.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FANCJ PRO-349
    17. 18.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS FANCJ HIS-255; CYS-647 AND CYS-707;VARIANT TRP-264
    18. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-919
    19. 20.
      "Fanconi anemia group J mutation abolishes its DNA repair function by uncoupling DNA translocation from helicase activity or disruption of protein-DNA complexes."
      Wu Y. , Sommers J.A. , Suhasini A.N. , Leonard T. , Deakyne J.S. , Mazin A.V. , Shin-Ya K. , Kitao H. , Brosh R.M. Jr.
      Blood116:3780-3791(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT FANCJ PRO-349;COFACTOR;CHARACTERIZATION OF VARIANT FANCJ PRO-349
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