Gene name:
BRIP1 (BACH1;FANCJ) ;
Protein name:
Fanconi anemia group J protein (Protein FACJ) ;
Alternative:
BRCA1-associated C-terminal helicase 1 ;ATP-dependent RNA helicase BRIP1 ;BRCA1-interacting protein C-terminal helicase 1 (BRCA1-interacting protein 1) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Binds directly to the BRCT domains of BRCA1.
Function:
DNA-dependent ATPase and 5' to 3' DNA helicase required for the maintenance of chromosomal stability. Acts late in the Fanconi anemia pathway, after FANCD2 ubiquitination. Involved in the repair of DNA double-strand breaks by homologous recombination in a manner that depends on its association with BRCA1.
Subcellular Location:
Nucleus
Protein Attributes:
50:
MSSMWSEYTI | GGVKIYFPYK | AYPSQLAMMN | SILRGLNSKQ | HCLLESPTGS |
100:
GKSLALLCSA | LAWQQSLSGK | PADEGVSEKA | EVQLSCCCAC | HSKDFTNNDM |
150:
NQGTSRHFNY | PSTPPSERNG | TSSTCQDSPE | KTTLAAKLSA | KKQASIYRDE |
200:
NDDFQVEKKR | IRPLETTQQI | RKRHCFGTEV | HNLDAKVDSG | KTVKLNSPLE |
250:
KINSFSPQKP | PGHCSRCCCS | TKQGNSQESS | NTIKKDHTGK | SKIPKIYFGT |
300:
RTHKQIAQIT | RELRRTAYSG | VPMTILSSRD | HTCVHPEVVG | NFNRNEKCME |
350:
LLDGKNGKSC | YFYHGVHKIS | DQHTLQTFQG | MCKAWDIEEL | VSLGKKLKAC |
400:
PYYTARELIQ | DADIIFCPYN | YLLDAQIRES | MDLNLKEQVV | ILDEAHNIED |
450:
CARESASYSV | TEVQLRFARD | ELDSMVNNNI | RKKDHEPLRA | VCCSLINWLE |
500:
ANAEYLVERD | YESACKIWSG | NEMLLTLHKM | GITTATFPIL | QGHFSAVLQK |
550:
EEKISPIYGK | EEAREVPVIS | ASTQIMLKGL | FMVLDYLFRQ | NSRFADDYKI |
600:
AIQQTYSWTN | QIDISDKNGL | LVLPKNKKRS | RQKTAVHVLN | FWCLNPAVAF |
650:
SDINGKVQTI | VLTSGTLSPM | KSFSSELGVT | FTIQLEANHI | IKNSQVWVGT |
700:
IGSGPKGRNL | CATFQNTETF | EFQDEVGALL | LSVCQTVSQG | ILCFLPSYKL |
750:
LEKLKERWLS | TGLWHNLELV | KTVIVEPQGG | EKTNFDELLQ | VYYDAIKYKG |
800:
EKDGALLVAV | CRGKVSEGLD | FSDDNARAVI | TIGIPFPNVK | DLQVELKRQY |
850:
NDHHSKLRGL | LPGRQWYEIQ | AYRALNQALG | RCIRHRNDWG | ALILVDDRFR |
900:
NNPSRYISGL | SKWVRQQIQH | HSTFESALES | LAEFSKKHQK | VLNVSIKDRT |
950:
NIQDNESTLE | VTSLKYSTPP | YLLEAASHLS | PENFVEDEAK | ICVQELQCPK |
1000:
IITKNSPLPS | SIISRKEKND | PVFLEEAGKA | EKIVISRSTS | PTFNKQTKRV |
1050:
SWSSFNSLGQ | YFTGKIPKAT | PELGSSENSA | SSPPRFKTEK | MESKTVLPFT |
1100:
DKCESSNLTV | NTSFGSCPQS | ETIISSLKID | ATLTRKNHSE | HPLCSEEALD |
1150:
PDIELSLVSE | EDKQSTSNRD | FETEAEDESI | YFTPELYDPE | DTDEEKNDLA |
1200:
ETDRGNRLAN | NSDCILAKDL | FEIRTIKEVD | SAREVKAEDC | IDTKLNGILH |
1249:
IEESKIDDID | GNVKTTWINE | LELGKTHEIE | IKNFKPSPSK | NKGMFPGFK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Chicken
ELISA Kit for Human Protein FACJ
ELISA Kit for Human Protein FACJ
ELISA Kit for Human Protein FACJ
CLIA Kit for Human Protein FACJ
CLIA Kit for Human Protein FACJ
CLIA Kit for Human Protein FACJ
Polyclonal Antibody for Human Protein FACJ
Polyclonal Antibody for Human Protein FACJ
Polyclonal Antibody for Human Protein FACJ
Monoclonal Antibody for Human Protein FACJ
Monoclonal Antibody for Human Protein FACJ
Monoclonal Antibody for Human Protein FACJ
Protein for Human Protein FACJ
Protein for Human Protein FACJ
Protein for Human Protein FACJ
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
"BACH1, a novel helicase-like protein, interacts directly with BRCA1 and contributes to its DNA repair function."
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Cell105:149-160(2001)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PROTEIN SEQUENCE OF 708-747; 765-790; 815-831; 1079-1085; 1169-1174 AND 1215-1225;FUNCTION;TISSUE SPECIFICITY;SUBCELLULAR LOCATION;INTERACTION WITH BRCA1;MUTAGENESIS OF LYS-52;VARIANTS BC ALA-47 AND ILE-299;VARIANTS ILE-193 AND SER-919;IDENTIFICATION BY MASS SPECTROMETRY
2.
"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
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Nature440:1045-1049(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
4.
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Nat. Genet.36:40-45(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 558-1249 (ISOFORM 2);VARIANT SER-919
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-990;MUTAGENESIS OF SER-986; SER-988; THR-989; SER-990; PRO-991; THR-992; PHE-993; THR-997; SER-1001; SER-1003; SER-1004; SER-1007; TYR-1011 AND THR-1013
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF LYS-52;CHARACTERIZATION OF VARIANTS BC ALA-47 AND ILE-299
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;VARIANT SER-919;DISEASE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;MUTAGENESIS OF LYS-52;DISEASE
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-927; SER-930 AND SER-990;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-930 AND SER-1032;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
11.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
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,
Jensen L.J.
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Jensen T.S.
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Brunak S.
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Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-1237;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ACETYLATION AT LYS-1249
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 985-998 IN COMPLEX WITH BRCA1;SUBUNIT
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CYS-173 AND SER-919
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS SER-919 AND LEU-1034
16.
"Mutational analysis of the BRCA1-interacting genes ZNF350/ZBRK1 and BRIP1/BACH1 among BRCA1 and BRCA2-negative probands from breast-ovarian cancer families and among early-onset breast cancer cases and reference individuals."
Rutter J.L.
,
Smith A.M.
,
Davila M.R.
,
Sigurdson A.J.
,
Giusti R.M.
,
Pineda M.A.
,
Doody M.M.
,
Tucker M.A.
,
Greene M.H.
,
Zhang J.
,
Struewing J.P.
Hum. Mutat.22:121-128(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS CYS-173; ILE-193; PRO-195; TRP-419; VAL-531; LEU-540; TYR-832; SER-919 AND GLY-935
17.
"The BRCA1-interacting helicase BRIP1 is deficient in Fanconi anemia."
Levran O.
,
Attwooll C.
,
Henry R.T.
,
Milton K.L.
,
Neveling K.
,
Rio P.
,
Batish S.D.
,
Kalb R.
,
Velleuer E.
,
Barral S.
,
Ott J.
,
Petrini J.
,
Schindler D.
,
Hanenberg H.
,
Auerbach A.D.
Nat. Genet.37:931-933(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT FANCJ PRO-349
18.
"The DNA helicase BRIP1 is defective in Fanconi anemia complementation group J."
Levitus M.
,
Waisfisz Q.
,
Godthelp B.C.
,
Vries Y.
,
Hussain S.
,
Wiegant W.W.
,
Elghalbzouri-Maghrani E.
,
Steltenpool J.
,
Rooimans M.A.
,
Pals G.
,
Arwert F.
,
Mathew C.G.
,
Zdzienicka M.Z.
,
Hiom K.
,
De Winter J.P.
,
Joenje H.
Nat. Genet.37:934-935(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANTS FANCJ HIS-255; CYS-647 AND CYS-707;VARIANT TRP-264
19.
"DNA sequencing of a cytogenetically normal acute myeloid leukaemia genome."
Ley T.J.
,
Mardis E.R.
,
Ding L.
,
Fulton B.
,
McLellan M.D.
,
Chen K.
,
Dooling D.
,
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,
McGrath S.
,
Hickenbotham M.
,
Cook L.
,
Abbott R.
,
Larson D.E.
,
Koboldt D.C.
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[
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Abstract ]
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Cited for : VARIANT [LARGE SCALE ANALYSIS] SER-919
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Cited for : VARIANT FANCJ PRO-349;COFACTOR;CHARACTERIZATION OF VARIANT FANCJ PRO-349