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Index > Protein center > FANCL(Gene name) > Human
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  • FANCL (Gene name),
  • E3 ubiquitin-protein ligase FANCL (Protein name ),  FANCL_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    FANCL(PHF9);
    Protein name:
    E3 ubiquitin-protein ligase FANCL;
    Alternative:
    Fanconi anemia-associated polypeptide of 43 kDa(FAAP43);Fanconi anemia group L protein;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with GGN (By similarity). Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. The complex is not found in FA patients. In complex with FANCF, FANCA and FANCG, but not with FANCC, nor FANCE, interacts with HES1; this interaction may be essential for the stability and nuclear localization of FA core complex proteins.
    Function:
    Ubiquitin ligase protein that mediates ubiquitination of FANCD2, a key step in the DNA damage pathway. May be required for proper primordial germ cell proliferation in the embryonic stage, whereas it is probably not needed for spermatogonial proliferation after birth.
    Subcellular Location:
    Cytoplasm Nucleus
    Protein Attributes:
    Sequence length:
    375
    Sequence:
    50:
    MAVTEASLLR | QCPLLLPQNR | SKTVYEGFIS | AQGRDFHLRI | VLPEDLQLKN | 
    100:
    ARLLCSWQLR | TILSGYHRIV | QQRMQHSPDL | MSFMMELKML | LEVALKNRQE | 
    150:
    LYALPPPPQF | YSSLIEEIGT | LGWDKLVYAD | TCFSTIKLKA | EDASGREHLI | 
    200:
    TLKLKAKYPA | ESPDYFVDFP | VPFCASWTPQ | SSLISIYSQF | LAAIESLKAF | 
    250:
    WDVMDEIDEK | TWVLEPEKPP | RSATARRIAL | GNNVSINIEV | DPRHPTMLPE | 
    300:
    CFFLGADHVV | KPLGIKLSRN | IHLWDPENSV | LQNLKDVLEI | DFPARAILEK | 
    350:
    SDFTMDCGIC | YAYQLDGTIP | DQVCDNSQCG | QPFHQICLYE | WLRGLLTSRQ | 
    375:
    SFNIIFGECP | YCSKPITLKM | SGRKH
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    KEGG:
    Pfam:
    String:
    MIM:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human E3 ubiquitin-protein ligase FANCL
    ELISA Kit for Human E3 ubiquitin-protein ligase FANCL
    CLIA Kit for Human E3 ubiquitin-protein ligase FANCL
    CLIA Kit for Human E3 ubiquitin-protein ligase FANCL
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase FANCL
    Polyclonal Antibody for Human E3 ubiquitin-protein ligase FANCL
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase FANCL
    Monoclonal Antibody for Human E3 ubiquitin-protein ligase FANCL
    Protein for Human E3 ubiquitin-protein ligase FANCL
    Protein for Human E3 ubiquitin-protein ligase FANCL

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Teratocarcinoma.
    2. 2.
      "Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
      Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
      Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Eye.
    4. 4.
      "A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome."
      Meetei A.R. , Sechi S. , Wallisch M. , Yang D. , Young M.K. , Joenje H. , Hoatlin M.E. , Wang W.
      Mol. Cell. Biol.23:3417-3426(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY IN A BRAFT COMPLEX WITH FANCA; FANCC; FANCE; FANCF AND FANCG
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INVOLVEMENT IN FANCL;INTERACTION WITH FANCA; FANCC; FANCF AND FANCG;MUTAGENESIS OF CYS-307 AND CYS-310
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH FANCA; FANCB; FANCC; FANCE; FANCF AND FANCLG
    7. 7.
      "A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M."
      Meetei A.R. , Medhurst A.L. , Ling C. , Xue Y. , Singh T.R. , Bier P. , Steltenpool J. , Stone S. , Dokal I. , Mathew C.G. , Hoatlin M. , Joenje H. , de Winter J.P. , Wang W.
      Nat. Genet.37:958-963(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH FANCA; FANCB; FANCC; FANCE; FANCF; FANCG AND FANCM
    8. 8.
      "UBE2T is the E2 in the Fanconi anemia pathway and undergoes negative autoregulation."
      Machida Y.J. , Machida Y. , Chen Y. , Gurtan A.M. , Kupfer G.M. , D'Andrea A.D. , Dutta A.
      Mol. Cell23:589-596(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2T;UBIQUITINATION;MUTAGENESIS OF CYS-307 AND TRP-341
    9. 9.
      "UBE2T, the Fanconi anemia core complex, and FANCD2 are recruited independently to chromatin: a basis for the regulation of FANCD2 monoubiquitination."
      Alpi A. , Langevin F. , Mosedale G. , Machida Y.J. , Dutta A. , Patel K.J.
      Mol. Cell. Biol.27:8421-8430(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2T;MUTAGENESIS OF CYS-307 AND CYS-310
    10. 10.
      "HES1 is a novel interactor of the Fanconi anemia core complex."
      Tremblay C.S. , Huang F.F. , Habi O. , Huard C.C. , Godin C. , Levesque G. , Carreau M.
      Blood112:2062-2070(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HES1;SUBCELLULAR LOCATION
    11. 11.
      "Mechanistic insight into site-restricted monoubiquitination of FANCD2 by Ube2t, FANCL, and FANCI."
      Alpi A.F. , Pace P.E. , Babu M.M. , Patel K.J.
      Mol. Cell32:767-777(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH UBE2T AND UBE2W;MUTAGENESIS OF 158-TYR-PRO-159; CYS-307 AND CYS-359
    12. 12.
      "FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL."
      Longerich S. , San Filippo J. , Liu D. , Sung P.
      J. Biol. Chem.284:23182-23186(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-307
    13. 13.
      "FAAP20: a novel ubiquitin-binding FA nuclear core-complex protein required for functional integrity of the FA-BRCA DNA repair pathway."
      Ali A.M. , Pradhan A. , Singh T.R. , Du C. , Li J. , Wahengbam K. , Grassman E. , Auerbach A.D. , Pang Q. , Meetei A.R.
      Blood119:3285-3294(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN THE FA COMPLEX
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS];CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS]
    15. 15.
      "Structural analysis of human FANCL, the E3 ligase in the Fanconi anemia pathway."
      Hodson C. , Cole A.R. , Lewis L.P. , Miles J.A. , Purkiss A. , Walden H.
      J. Biol. Chem.286:32628-32637(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 109-294;INTERACTION WITH FANCI AND UBE2T;MUTAGENESIS OF 127-VAL-TYR-128; LEU-149; PHE-166; 212-TRP--LEU-214; LEU-248; PHE-252; LEU-254 AND ILE-265
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